Centre National de la Recherche Scientifique

Natural product-derived compounds modulating STAT3 signaling in prostate cancer: Mechanistic insights and therapeutic potential

Prostate cancer (PCa) is a major malignancy in men and current treatment options remain limited by therapeutic resistance and treatment-related toxicity. Signal transducer and activator of transcription 3 (STAT3) is a key regulator of PCa progression and an attractive therapeutic...

Tuning the Activation Barrier for Oxygen Exchange on Mixed Conducting Oxide with Fine Control of Transition Metal Impurities

Abstract The energy barrier for oxygen exchange at the surface of mixed conducting oxides is a multifactor term that remains difficult to predict with existing models. Here, we describe an experimental approach to fine-tune this barrier on Pr0.1Ce0.9O2-δ used as a model mixed con...

Symmetry-based pulsed DNP and EPR sequences

Pulsed microwave irradiation provides more versatile control over spin dynamics than continuous-wave (CW) methods. This study adapts symmetry-based dipolar recoupling sequences, which are originally designed for magic angle spinning (MAS) NMR, to exploit electron-nuclear interact...

Covalent Functionalization of 2D Semiconductors: A Roadmap to Advanced Electronic Devices

ABSTRACT Two‐dimensional (2D) semiconductors have emerged as key components for next‐generation electronic, optoelectronic, and sensing technologies. Accordingly, there has been growing interest in tuning their properties to enhance functionality and enable multiple capabilities...

Climatology and trends of extreme precipitation in France: evaluation of an explicit-convection regional climate model

Climate change is intensifying the global water cycle, with extreme precipitation events increasing in frequency and intensity at the global scale. While trends in daily precipitation extremes are well-documented, sub-daily extremes – critical for flash flood risk – remain poorly...

Correlation and Prediction of Liquid–Liquid and Solid-Liquid Equilibrium for the Phenol (C6H5OH) + n- Hexane (C6H14) Binary System Using the NRTL and COSMO-Based Models

Abstract This study investigates the thermodynamic phase behavior of the binary system phenol (C6H5OH) + n-hexane (C6H14), a mixture relevant to separation processes in refining and coal conversion. Liquid–liquid equilibrium (LLE) and solid–liquid equilibrium (SLE) data were meas...

Unravelling the impact of nitrogen deprivation on the morphology and nanomechanical properties of Parachlorella kessleri

Abstract Nitrogen deprivation is commonly applied to enhance lipid accumulation in microalgae for third-generation biofuel production. However, its influence on cell wall morphology and nanomechanical properties, which critically affect downstream processing, remains poorly explo...

Molecular mechanism of calcium inhibition in viral channelrhodopsins

Abstract Viral channelrhodopsins (VCR1s) are giant-virus-encoded light-gated channels permeable to monovalent and divalent cations, including Na + and Ca 2+ ions, and inhibited by millimolar Ca 2+ concentrations. Here, we combine X-ray crystallography, time-resolved UV-vis spectr...

Identification of a Point Source in the Heat Equation from Sparse Boundary Measurements

Abstract. In this work we investigate the inverse problem of recovering one point source in the heat equation from sparse boundary measurement, i.e., the flux data at several points on the boundary. We prove the unique recovery of the location and piecewise constant in time ampli...

The Second Nitrogen Fits: Development of Diazine-Based Macrocyclic Chelators to Stably Bind Radionuclides Used in Targeted Alpha Therapy

Abstract Identifying suitable chelators for 212Pb, 223Ra, and 225Ac and their diagnostic counterparts 131Ba, 133La, and 203Pb remains one of the major challenges in the development of radiopharmaceuticals for targeted alpha therapy. Four novel macrocyclic chelators containing the...

Mangrove sediments as carbon sinks: a global analysis of research patterns, trends and future directions

Abstract Mangrove sediments are widely recognized as an important component of long-term carbon storage in coastal ecosystems. However, the structure, evolution, and thematic organization of the scientific literature addressing mangrove sediment carbon have not yet been clearly c...

Linking Rainfall Simulation and Single-Ring Measurements on a Swiss Alpine Hillslope: A Novel Framework for Surface Runoff Estimation

Surface runoff in alpine catchments is sensitive to rainfall intensity, resulting in substantial variations in runoff coefficients across rainfall scenarios. Although this dependency is well documented in the literature, it is often neglected in practical applications by assuming...

Anesthesia TeleConsultation for Pediatric preoperative assessment: a large national prospective multicentric study in children (TeleCCCAP)

Background: While interest in pediatric anesthesia teleconsultation is growing, published data remain scarce. This study evaluated the feasibility of anesthesia teleconsultation in children, providing a comprehensive analysis of failure, quality, dedicated time and satisfaction....

Determining a graph from its reconfiguration graph

Given a graph G and a natural number k , the k -recolouring graph C k ( G ) is the graph whose vertices are the k -colourings of G and whose edges link pairs of colourings which differ at exactly one vertex of G . Recently, Hogan et al. proved that G can be determined from C k (...

Convolution and square in abelian groups II

A critical value on an abelian group G of odd order d is a value λ such that the functional equation f ☆ f ( 2 t ) = λ f ( t ) 2 on G has a nonzero solution f . We construct many critical values by using abelian varieties with complex multiplication.

Development and investigation of a NiO/ZnO@PPy-modified glassy carbon electrode for electrochemical sensing of metronidazole in environmental samples: Experimental and DFT studies

Metronidazole (MTZ) is widely prescribed as an antimicrobial drug, and its extensive use in animal farming has led to its accumulation in the environment, posing significant risks to human health and the environment. In this study, nickel and zinc oxide (NiO/ZnO) composite materi...

Zileuton protects pancreatic stellate cells from oxidative stress and ferroptosis by modulating the Nrf2 pathway and mitochondrial activity

Abstract Lipoxygenases exhibit a leading role in cancer development and growth. Additionally, pancreatic stellate cells (PSCs) are pivotal in the formation of fibrotic tissue in pancreatic tumors. In this work, we have studied the effects of the 5-lipoxygenase (5-LOX) inhibitor,...

Uniqueness of Adapted Solutions to Scalar BSDEs with Peano-Type Generators

Abstract. A backward stochastic differential equation (BSDE) with a Peano-type generator is known to have infinitely many solutions when the terminal value is vanishing, and it is shown to have possibly multiple solutions even when the terminal value is not vanishing but nonnegat...

International Protocol for the Study of Amorphous Charred Objects in Archaeology (IPSACO 1.0)

Abstract Archaeobotanists around the world increasingly recognise that, alongside commonly studied materials such as seeds, fruits, wood charcoal, and chaff, archaeobotanical samples also contain fragments of carbonised organic (and sometimes inorganic) matter that vary in shape...

Large-scale climate drivers of extreme compound events in the Amazon from interannual to long-term timescales (1982–2024)

Abstract Over recent decades Amazonia has experienced a marked intensification of floods and droughts. The record-breaking 2023–2024 drought, characterized by exceptional heat and dryness, motivates a closer analysis of compound extremes and their large-scale drivers. This study...