Research works

Evaluating commercial DNA extraction kits for bacterial community profiling in waterlogged archaeological wood

Understanding bacterial communities responsible for the slow biodeterioration of waterlogged archaeological wood is critical for reconstructing decay processes, predicting preservation trajectories, and informing conservation strategies. The extraction of sufficient and amplifiab...

Interpretable epigenetic clock links aging pathways and disease-specific methylation profiles

Abstract We developed an interpretable blood-based epigenetic clock to estimate DNA methylation age and identify disease-specific DNA methylation alterations. Using 8233 Illumina methylomes from healthy controls and nine age-associated diseases, we used ridge selection to retain...

Skills to build the nation: immigrant labour market and Canadian nationalism

In Skills to Build the Nation, Chatterjee argues that the postwar focus in Canadian immigration and integration policies on skill (and, relatedly, Canadian experience) is not instrumental but the l...

Trace-element enrichment in agricultural soils under wastewater-influenced surface-water irrigation: a plot-scale study in an Andean micro-watershed

Abstract The use of wastewater-influenced surface waters for agricultural irrigation is common in many regions, yet its implications for soil geochemistry remain insufficiently characterized, particularly in Andean micro-watersheds. This study evaluates the occurrence and distrib...

Electric Vehicle Routing Problem with Time Windows and Flexible Service Locations

The rapid development of shared delivery, parcel lockers, and community pickup services has enabled customers to receive orders at multiple alternative service locations. In such scenarios, the fixed-location assumption adopted in traditional electric vehicle routing problems is...

Do Patients Receiving GLP-1 Receptor Agonists for Weight Loss Require Structured Dietetic Care? Lessons from Metabolic and Bariatric Surgery (MBS) Pathways

Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual incretin therapies have significantly advanced obesity management by facilitating clinically significant weight loss and enhancing cardiometabolic outcomes. Nevertheless, their growing application calls fo...

CalliGAN: multi-scale gradient and self-attention GAN for ancient calligraphy synthesis

Chinese calligraphy synthesis supports digital heritage preservation, but remains challenging due to complex brushstrokes and global structural requirements. We present CalliGAN, a Generative Adversarial Network (GAN) with two variants: CalliGAN-Gen for unconditional character ge...

EPIDEMIOLOGY AND DIRECTIONS FOR PROPHYLAXIS OF CHRONIC BRONCHIAL OBSTRUCTION IN EMERGENCY MEDICAL CARE SETTINGS

<p>Clinical and epidemiological studies show that bronchial obstruction associated with bronchial asthma and chronic obstructive pulmonary disease is widespread among the population of different ages and that its frequency of detection varies in regions. Therefore, interest...

MSC–Hydrogel Composite Systems for Knee Cartilage Repair and Osteoarthritis: A Systematic Review

Background: MSC–hydrogel composite systems were developed to overcome the poor cell retention and limited durability of conventional marrow stimulation and suspension-based MSC delivery. A rigorous synthesis of the clinical evidence is lacking. Objectives: To evaluate the safety...

The Software Lens: Eliminating Prescription Inserts in Near-Eye Displays via Inverse Ray Backtracing and Per-Pixel Directional Emission

Users with refractive errors -- roughly one third of the world's population today, projected to approach one half by 2050 -- cannot use consumer VR headsets comfortably without corrective optics. The industry's answer is the prescription insert (RX insert): a custom-ground lens p...

Institutional determinants of ISSA 5000 readiness in Latin American universities: evidence from a multinomial logistic model

Purpose This study identifies the institutional factors that condition the probability of Latin American higher education institutions (HEIs) reaching different readiness levels for external sustainability assurance under ISSA 5000 the first international standard on sustainabili...

Cortical Columns, Capsules, and Transformers: A Typed Benchmark for Part-Whole Representation, Reference Frames, Routing, and Receiver-Relative Dynamics

# Cortical Columns, Capsules, and Transformers Recognizing a moving or partly hidden object requires a system to preserve relations among parts, wholes, pose, context, time, and action while its immediate inputs change. This paper makes a direct operational comparison among corti...

Factors That Influence Technology-Facilitated Intimate Partner Violence: A Scoping Review Using Systems Thinking

Technology-facilitated intimate partner violence (TFIPV) is increasingly featured in cases of intimate partner violence and intimate partner homicide. There is emerging recognition of the use of technology to abuse and control intimate partners in domestic abuse research and the...

How Do Child Protection Workers Report and Assess Signs of Honour‐Based Violence? An Analysis of 138 Cases

ABSTRACT Honour‐based violence (HBV) is a serious social problem with significant health and social consequences for affected children. Despite growing policy attention, little is known about how child protection services address HBV in practice. This study examines how child pro...

Atomically Precise Rigid Copper Nanocluster as an Air‐Stable Photocatalyst for Three‐Component Coupling Reactions

ABSTRACT Copper‐based catalysts exhibit high versatility in organic synthesis. However, their practical utility is often constrained by the limited stability and sensitivity to reaction conditions. In this study, we report a μ 3 – η 1 –S‐bridged nanocluster (NC), Cu 3 (DPPM) 3 S(...

Pharmacist Assisted Cessation of Tobacco and Support for Lung Cancer Screening (PACTS) study

Central repository for the Pharmacist-Assisted Cessation of Tobacco and Support for Lung Cancer Screening (PACTS) program of research at Fred Hutchinson Cancer Center. PACTS is a community pharmacy–based intervention that integrates tobacco cessation services, identification of a...

Analytical calculation of field enhancement factor of 2D structure graphene film

Field emitters are one of the promising electron sources for vacuum electronic devices operating in mm-wave and terahertz frequencies, where emission performance is critically governed by the field enhancement factor. While extensive analytical models exist for one-dimensional em...

Systematic review and meta-analysis of adoption, acceptance, and perceptions of precision livestock farming technology

Digital technologies are increasingly reshaping livestock production systems, with precision livestock farming (PLF) emerging as a key innovation that uses sensor-based monitoring and data analytics to support animal management, welfare oversight, and decision-making on farms. De...

TCGA-based identification and functional validation of PBK in intrahepatic cholangiocarcinoma progression with involvement of AKT signaling

Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with limited molecular targets. This study aimed to identify candidate genes involved in ICC progression and to examine the functional role of PBK. Integrated bioinformatics analysis was performed on TCGA-CHOL data...

Partial symptom remission in occupational pesticide-related parkinsonism: a case report

Parkinson’s disease (PD) is a progressive neurodegenerative disorder in which environmental exposures, particularly pesticides, are increasingly recognized as relevant risk factors. Chronic occupational pesticide exposure has been associated with increased PD risk, yet clinical i...