Research works

Unraveling the molecular Nexus of Alzheimer’s Disease and HIV encephalitis: The role of cellular senescence and transcriptional regulation

Alzheimer’s disease (AD) and HIV-associated neurocognitive disorder (HAND) share progressive cognitive decline. Their common molecular mechanisms remain poorly understood. Current therapeutic approaches lack effective biomarkers for early diagnosis and intervention. We integrated...

Single-cell profiling of peripheral blood mononuclear cells in diverse men with prostate cancer reveals a fatal disease-associated immune signature

Abstract Alterations in peripheral immunity may contribute to fatal prostate cancer and the excessive disease burden among African American (AA) men. Thus, we investigated peripheral immunity in prostate cancer patients in association with disease outcome and AA descent. We perfo...

LAB #986 PROMISING: LEDGER BENCH: Apply filter: XAUUSD LONG @ ASIAN with 5 conf — improves win rate from 31.6% to 66.7% — E8 Intelligence Research

IDEA: Adjustment made to the live model — verify against the backtests: Apply filter: XAUUSD LONG @ ASIAN with 5 conf — improves win rate from 31.6% to 66.7% (+35.0pp, n=21) SAME-WINDOW EFFECT: Over the current trade window, applying the XAUUSD LONG @ ASIAN with 5 conf filter wou...

Joint high level of low-density lipoprotein and high-sensitivity C-reactive protein are associated with early neurological deterioration after thrombolysis in patients with mild stroke

Low-density lipoprotein (LDL) and high-sensitivity C-reactive protein (hs-CRP) play important roles in cardiovascular and cerebrovascular diseases through pathways such as inflammation and oxidative stress. We aimed to explore whether LDL and hs-CRP were associated with early neu...

Failure Modes of Total Wrist Arthroplasty: Cross-Sectional Analysis of FDA MAUDE Adverse Event Reports (2015-2025)

Background: Total wrist arthroplasty (TWA) is a motion-preserving alternative to wrist fusion for end-stage wrist arthritis, but concerns regarding long-term durability continue to limit broader use. Reported 10-year survivorship ranges from 70% to 80%, although real-world failur...

Prevalence and Antimicrobial Resistance of Pseudomonas aeruginosa Recovered from Respiratory and Urinary Specimens in a Lebanese Hospital (2020–2025)

Background: Respiratory tract infections (RTIs) and urinary tract infections (UTIs) are among the most common infections in humans. It is estimated that millions of deaths occur each year worldwide due to these infections. Pseudomonas aeruginosa (P. aeruginosa), in particular, re...

Builder Engine 3.5.7: Blueprint of a Verifiable Architecture Language and System Factory

Builder Engine is two things in one system: a language in which architecture is declared as verifiable constraints, and a factory that builds a system from that contract. The inversion that defines the language is that it does not state what a system is but what cannot happen in...

Comparison of autologous platelet-rich plasma injection with air tamponade versus C3F8 tamponade in idiopathic full-thickness macular hole surgery

Vitrectomy, combined with internal limiting membrane peeling and gas tamponade, is the gold standard for treating full-thickness macular holes (FTMH). However, prolonged intraocular tamponade duration often causes patient discomfort and delays visual recovery, necessitating the n...

Awareness and perceptions of patient and public involvement in rare disease research in Japan: the role of patient advocacy groups and family members

Abstract Background Patient and public involvement (PPI) in medical research has increasingly been incorporated into research policies and funding frameworks in Japan, but empirical evidence on how patients and family members perceive PPI remains limited. This is particularly imp...

Synthesis of (FeCoNiCuMn)S high-entropy sulfide nanorods and its enhanced oxygen evolution reaction performance

High-entropy sulfides (HESs) have emerged as promising electrocatalysts for the oxygen evolution reaction (OER) due to their unique compositional tunability and synergistic effects. In this work, we report the rational synthesis of (FeCoNiCuMn)S HES nanorods via a facile hydrothe...

Electron Transferto Colloidal ZnO Nanocrystals fromthe Excited State of a Perylene Chromophore Formed by Direct Excitationor Triplet–Triplet Annihilation Upconversion

Abstract Upon binding 4-(perylen-3-yl)benzoic acid 1, to oleate-capped ZnO nanocrystals (NCs), significant broadening of the perylene absorption spectrum and fluorescence quenching were observed. In contrast, no broadening of the absorption spectrum or fluorescence quenching was...

Media, police shootings and mental illness: Is stigma a problem?

Objectives: Fatal police shootings in Australia have increased in recent years, with a substantial portion of these incidents involving individuals with mental illness and often attracting extensive media coverage. This study investigates whether mainstream newspaper reporting us...

LAB #969 NEUTRAL: LEDGER BENCH: Apply filter: Pool density HIGH (>=90) — improves win rate from 31.6% to 33.2% (+1.6pp — E8 Intelligence Research

IDEA: Adjustment made to the live model — verify against the backtests: Apply filter: Pool density HIGH (>=90) — improves win rate from 31.6% to 33.2% (+1.6pp, n=1328) **SAME-WINDOW EFFECT:** Applying the HIGH pool density filter (≥90) to the live window would have rejected the E...

An Intelligent Framework for Forecasting Cardiovascular Disease using Bio-inspired Optimization and ML

Inderscience is a global company, a dynamic leading independent journal publisher disseminates the latest research across the broad fields of science, engineering and technology; management, public and business administration; environment, ecological economics and sustainable dev...

A generalized artificial neural network (ANN) model for predicting construction project durations based on cost and geolocation data

Purpose Reliable construction project duration estimation remains a persistent challenge due to the complex interactions among project characteristics and the diversity of construction environments. While previous prediction models have frequently relied on project-specific varia...

An Essential Parameters of Clostridium Perfringens Infection Include Objectives, Etiology, Epidemiology, Pathophysiology, Histopathophysiology, Diagnosis, Differential Diagnosis, Treatment and Prognosis

The anaerobic Gram-positive spore-forming bacillus Clostridium perfringens is linked to acute gastrointestinal infections in people that range in severity from diarrhea to necrotizing enterocolitis and myonecrosis. This pathogen can produce spores that are resistant to environmen...

Mechanisms of Multi-Toxicant Oxidative Stress: Dysregulation of The NF-Κb/Iκb Axis By Ozone, 4-(N-Methyl-N-Nitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) and/or Dibutyl Phthalate (DBP)

ABSTRACT This study explores the NF-κB-mediated oxidative stress pathways in B6C3F1 mouse lungs and livers following 16- and 32-week exposures to ozone, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and/or dibutyl phthalate (DBP). EMSA and Western blot analyses reveal...

Post-Traumatic Stress Symptoms and Dissociation in Emergency Medical Service Personnel

Background: Emergency medical service (EMS) personnel and volunteers are frequently exposed to traumatic events, placing them at elevated risk for psychological distress, including post-traumatic stress symptoms (PTSSs), depression, and dissociation. This study examined the relat...

Immune checkpoint blockade sensitivity is linked to endogenous retroelement transcriptional changes in cancer

Abstract Endogenous retrotransposable elements (EREs) can modulate immune responses. We explored ERE transcription in relation to response to immune checkpoint inhibition in advanced solid tumors. ERE expression was measured in pre and on-treatment samples from patients treated i...

In-human assessment of target engagement and blockade of radiolabeled BI 765063, an anti-SIRPα antibody

The signal regulatory protein alpha (SIRPα) receptor on myeloid cells binds cluster of differentiation (CD) antigen CD47 on tumor cells, resulting in a “don’t eat me” signal that inhibits phagocytosis. BI 765063, an anti-SIRPα antibody, may restore anti-tumor immunity by blocking...