Research works

Breast metastasis from BRCA1-mutated ovarian cancer: response to parp inhibition and a potential lymphatic route

Abstract Background Breast metastasis from extramammary malignancies is rare, with ovarian cancer being an exceptionally uncommon primary source. These metastases frequently mimic primary breast carcinoma, posing substantial diagnostic and therapeutic challenges. Case presentatio...

Optimizing coronary CT angiography in patients with delayed contrast arrival using a free-breathing, high-threshold bolus-tracking protocol

OBJECTIVE: To investigate the performance of a free-breathing coronary computed tomography angiography (CCTA) protocol using a high-threshold bolus-tracking strategy in improving coronary enhancement and diagnostic visualization in patients with delayed contrast arrival. MATERIAL...

Herpetofauna in Southern Philippine Indigenous Mythology

The indigenous tribes of the Southern Philippines, whose members refer to themselves as Lumad, still preserve their animistic beliefs, traditions, and rituals. During numerous expeditions and research field trips to remote parts of the island of Mindanao, my collaboration with th...

Mining of NovelHuman DPP-IV-Targeting Tripeptidesthrough Multicomputational Screening and In Vitro Validation for DiabetesTherapy

Abstract Inhibition of human dipeptidyl peptidase IV (hDPP-IV) is considered an effective strategy in the management of type 2 diabetes (T2D). However, the lack of high-throughput screening approaches and the high cost of experimental evaluation have limited the discovery of pept...

Tracking Rare Turtles in Southern China: Beal's Four-eyed Turtle (Sacalia bealei)

Chelonians (turtles and tortoises) are among the oldest and most fascinating biological groups on Earth. As a unique branch of reptiles, they play a crucial role in maintaining ecosystem health and biodiversity. Their most remarkable feature lies in their distinctive anatomy: a d...

Group sequential designs and a sample size reestimation approach for partially nested trials

Abstract Background Randomized controlled trials are the gold standard for evaluating interventions. For individually randomized trials, clustering can exist in the intervention arm but not the control arm when the intervention is delivered by study personnels and/or in a group s...

Responsive architecture for transforming vulnerable realities in the Global South

Abstract This article examines how responsive architecture can transform the realities of vulnerable communities in Global South contexts. Conventional definitions of architectural excellence privilege form and technology over social impact; this study reconceptualises excellence...

The World of Steve Angeli: Living with Baby Dinosaurs

Steve Angeli’s journey is a powerful story of passion, recovery, and faith. From catching lizards in the hills of Oakland to becoming a global authority on the genus Heloderma, his dedication has shaped the modern herpetocultural landscape. In this conversation with Foster Reves,...

Prognostic value of tissue-based DNA methylation biomarkers in non-small cell lung cancer: a systematic review

Abstract Background Non-small cell lung cancer remains a leading cause of cancer-related death worldwide, with varied outcomes despite advances in therapy. Epigenetic modifications, especially DNA methylation, are crucial regulators of gene expression and have been linked to NSCL...

The Sword of Truth: Why the Pinocchio Chameleon has such a Long Nose

Deep in the lush rainforests of central eastern Madagascar, where waterfalls whisper secrets and ferns dance in the mist, lives achameleon so flamboyant it could moonlight as a carnival performer. Calumma pinocchio Glaw & al., 2025, the so-called Pinocchio chameleon, is a small b...

Ethical compromise, valuing life, and Fechner's Law

Ethical compromise, valuing life, and Fechner's Law Authors: Nigel Harvey, Xiaozhou TanAffiliation: Department of Experimental Psychology, University College London (UCL)Principal Investigator: Prof. Nigel HarveyLicence: Creative Commons Attribution 4.0 International (CC BY 4.0)D...

MIBO Core Protocol Package v1.0

MIBO Core Protocol Package v1.0 provides the version-controlled methodological specification for MIBO Core, a sentinel panel survey of public generative-AI information behavior. The package defines persistent public service-lineage panel units, a fixed bilingual query instrument,...

Idiopathic Tinnitus: A Testable Bio-Electronic Behavioral Analogy — The Wave-Interference Interpretation of Tinnitus (WIIT)

Idiopathic tinnitus—subjective, audiogram-independent, without an identified medical etiology—remains without a satisfying explanatory account for a substantial subset of cases, and no directly comparable methodological precedent linking such presentations to documented interfere...

Inclisiran-induced LDL-cholesterol reduction with and without concomitant statin therapy: a real-world analysis

Abstract Inclisiran lowers LDL-cholesterol (LDL-C) by inhibiting hepatic PCSK9 synthesis. Whether concomitant statin therapy modifies the magnitude of inclisiran-associated LDL-C reduction in routine clinical practice remains uncertain. In this retrospective single-center observa...

Flagged Unitary–Replacer Channels: Sector-Resolved Choi-Moment Spectral Completion, Fixed-Fidelity Choi-Entropy Fibers, and Joint Transparency–Spectrum Identifiability

Within flagged unitary–replacer channels, optimized recovered entanglement fidelity is spectrally incomplete: it fixes weighted transparency but not the hidden replacer spectrum or conditional Choi entropy. For a resolved positive-probability sector with known transparency 0 ≤ a...

Governing Open Complex Giant Generative Relational Systems beyond Representation and Reach: A Synoptic Discussion of Systems, Scales, and Arrangements

Three companion papers establish results about the governance of systems that exceed what any party can represent or reach, and a fourth constitutes the class of problems such systems present. This paper adds the survey of the systems themselves that the four leave to be made. It...

Pan-3D genome of Gossypium hirsutum

This project generated Hi-C datasets from 12-DPA cotton fibers of 301 accessions. ATAC-seq, CUT&Tag, and RNA-seq datasets were also generated for a subset of these accessions.

Herping in Costa Rica: the Dry Lands (Pacific Versant)

As explored in a previous issue, a significant selection of the most popular and compelling herpetofauna of Costa Rica can be found along the Caribbean coast — globally recognised as one of the premier destinations for herpetological field observation in the world. A particularly...

Prediction of GlassTransition Temperatures for OrganicElectronic Materials

Abstract The glass transition temperature (Tg) is a critical descriptor governing the morphological stability, emitter orientation, and interfacial integrity of amorphous thin films in organic electronics. However, experimental Tg measurements suffer from high resource costs and...

Herping in Costa Rica: the Dry Lands (Pacific Versant)

As explored in a previous issue, a significant selection of the most popular and compelling herpetofauna of Costa Rica can be found along the Caribbean coast — globally recognised as one of the premier destinations for herpetological field observation in the world. A particularly...