Research works

Persistence in GLP-1–Based Therapy Among Adults with Obesity and Type 2 Diabetes: A Narrative Review of Definitions, Real-World Outcomes, and Determinants

Abstract Purpose of Review Persistence with glucagon-like peptide-1 (GLP-1)–based therapies is important for sustained weight loss and glycemic control in adults with coexisting obesity and type 2 diabetes. This narrative review examined how persistence has been defined and measu...

The Folman Phase Spine and the Operator-Complete pi/8 Reference-Switch Test

A passive coordinate seam is a negative control, not a physical reference switch. This paper develops a four-channel Gram-ratio test for an A1 reference switch. Its registered fork is simple: \[ H_{\rm std}:R_{\rm Gram}=1, \qquad H_{\rm QTT-A1}:R_{\rm Gram}=\cos\!\left(\frac{\pi}...

Spatial multiomics uncovers an SPP1+ macrophage-driven anti-apoptotic niche in osteoarthritis synovium via the SPP1-CD44 axis

This BioProject includes spatial transcriptomics data from human osteoarthritis (OA) and normal synovium, as well as RNA-seq data from mouse RAW264.7 cells treated with OPN, to investigate the functional subsets and spatial niches of synovial macrophages. Background: Osteoarthrit...

The impact of chemotherapy on frontal lobe executive functioning in adolescents and young adults diagnosed and treated for blood cancers: a systematic review

Abstract Background Cancer-related cognitive impairment (CRCI), often termed “chemobrain,” is a recognised effect of cancer therapy. However, most research has focused on older adults with solid tumours, leaving the neurocognitive consequences of chemotherapy in adolescents and y...

Evaluation and Optimization of Different DigestionStrategies for In-Depth Proteomic Characterization of Residual HostCell Proteins in rAAV-Based Gene Therapy Products

Abstract Recombinant adeno-associated virus vectors (rAAVs) are the most important vectors for in vivo gene therapies, yet their safety relies on low levels of residual host cell proteins (HCPs). While mass spectrometry-based proteomics enables sensitive and untargeted HCP profil...

Exploiting OmicData to Advance Predictive Ecotoxicology

Abstract Predicting species-specific chemical sensitivity using in silico approaches has the potential to transform environmental risk assessment, conservation, and biomonitoring, while reducing, and ultimately replacing, animal testing. Genomic and transcriptomic data capture ex...

Fintech Market Engagement in Financing Net-Zero Transitions: The Mediating Role of Digital Inclusion

This chapter discusses how capital markets (CMs) can be used to distribute the required financial resources to achieve the goals of net-zero emissions and digital inclusion (DI) in the Republic of Africa. It evaluates the ability of such markets to activate the kind of investment...

NOHEDD System for Ophthalmology: Implementation Framework for Real-Time Detection of Cognitive-Emotional Destabilization Through the Eye

NOHEDD — Neuro-Ocular High-Energy Destabilization Detection — is a non-invasive ocular monitoring system that detects destabilization of the mind through the eyes in real time. Clinical problem: Patients report visual fog, strain, instability under stress that does not map to OCT...

A hybrid SHA-256 and variational quantum classifier framework for simulation-based intrusion detection in SDN-IoT networks

Abstract The convergence of Software-Defined Networking (SDN) with Internet of Things (IoT) introduces critical security vulnerabilities requiring adaptive detection mechanisms. This paper presents QEIDS, a quantum-enhanced intrusion detection system combining SHA-256 cryptograph...

Structural Propagation Bounds under Local Updates: Reachability, Schedule, History, Capacity, and State-Continuation

This preprint presents a structural propagation-bound framework for local-update systems, distinguishing structural reachability from schedule-, history-, capacity-, and continuation-dependent constraints. It also gives a limited formal comparison with finite-rate and cone-like r...

Keeping and Breeding Karoo Dwarf Tortoises (Chersobius boulengeri)

Karoo dwarf tortoises belong to the group of so-called dwarf tortoises. The former genus Homopus, which included all five extant species of dwarf tortoises, was divided into the genera Homopus and Chersobius in 2017 (Hofmeyr et al., 2017). The genus Homopus now contains the speci...

Scene graph generation from point cloud panoptic segmentation for indoor scene understanding

Abstract Indoor scene understanding enables machines to comprehend 3D indoor environments by capturing object relationships and supporting spatial reasoning. Scene graphs are commonly used to represent objects and their relationships in a node–edge structure describing how neighb...

Herpetofauna in Southern Philippine Indigenous Mythology

The indigenous tribes of the Southern Philippines, whose members refer to themselves as Lumad, still preserve their animistic beliefs, traditions, and rituals. During numerous expeditions and research field trips to remote parts of the island of Mindanao, my collaboration with th...

The heliocentric worldview ontologically considered in quantum mechanics

This treatise develops an ontologically consistent, cybernetic model of the physical processes in the universe, describing stars, planets, photons, vortices, states of matter, and black holes as expressions of the same systemic dynamics. At its core is the insight that processual...

Just Innovation Is Not Enough: A Multi-Level Framework for Institutionalising Teaching and Learning Innovations in Higher Education

Abstract Despite decades of interest in teaching and learning (T&L) innovations, many fail to become institutionalised. This paper addresses this persistent challenge by proposing a new conceptual model—the Innovation Institutionalisation Framework (IIF). Developed through an...

A Temporal-Spatial Balloon Universe: A New Conceptual Primitive for Gravity and a Global Cosmological Model that Dissolves the Principal Paradoxes of ΛCDM

This paper proposes a conceptual reframing of cosmology and fundamental physics grounded in two related primitives: (1) a new local primitive for gravity, understood as an invariant, extremely weak action concentrated by radial geometry rather than as curvature taken as ontologic...

Genome sequencing of BJ-04

Whole genome sequencing data of a hexachlorobutadiene-degrading bacterial strain, BJ-04; PromethION platform from Oxford Nanopore Technologies used.

Fintech Market Engagement in Financing Net-Zero Transitions: The Mediating Role of Digital Inclusion

This chapter discusses how capital markets (CMs) can be used to distribute the required financial resources to achieve the goals of net-zero emissions and digital inclusion (DI) in the Republic of Africa. It evaluates the ability of such markets to activate the kind of investment...

Exploring the Mysterious Giant Salamander Kingdom: The Breeding Miracle, Commercial Utilization, and Ecological Giveback of the World's Largest Amphibian

China’s large-scale ecological propagation model has created a sustainable solution for the critically endangered Chinese giant salamander (Andrias davidianus). Kaiqi Wu investigates how modern commercial facilities, such as the Longjingquan Breeding Base maintaining over 90,000...

The effect of reduced carbohydrate diet on cardiometabolic risk factors and gut microbiota in children and adolescents with obesity: a randomized controlled trial

Abstract Objective To compare the effects of a reduced-carbohydrate diet (RCD) with a standard diet (STD) on cardiometabolic risk factors and gut microbiota composition in children and adolescents with obesity. Methods In this randomized controlled trial, 84 children and adolesce...