Research works

Spectral Capacity Functional and the Binary-Polyhedral Maximality Conjecture

The bounded-flux admissibility constraint of the Cosmochrony framework assigns to each spectral sector $\rho$ of a finite Cayley graph a maximal effective amplitude $A^{\max}_{\rho} = c_{\mathrm{BI}}/\sqrt{\lambda_{\rho}}$. Aggregated over all irreducible sectors with Peter Weyl...

Supporting 3Rs approaches in biologicals testing: responses from a survey of Manufacturers, Contract Research Organisations, National Control Laboratories and National Regulatory Authorities

In October 2023, the UK National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) presented recommendations to the World Health Organisation (WHO) Expert Committee for Biological Standardization following an audit of WHO vaccine and biotherapeut...

The Ontology of the Alien: World-Diversity Search and Evolving Solution Ontologies

Open-ended problems such as institutional design lack enumerable solution spaces and cheap automatic evaluators. World-diversity search moves variation upstream. Target-independent Builders construct textual worlds with altered causal rules; purpose-blind Solvers address the same...

Design and development of 5-aminoindan-based chemosensor for Hg2+ detection and cytotoxicity evaluation

Abstract Novel 5-aminoindan-based azo derivatives (3a–e) containing an indane moiety were designed and synthesized via diazotization and coupling reactions. The synthesized compounds were characterized by UV–Vis, FT-IR, 1 H NMR, and LC–MS spectral studies. Their electronic proper...

Methodology for the evaluation of low-carbon fuels in power generation gas turbine applications

This paper introduces a novel methodology based on the Theory of Constraints (TOC) to evaluate the adoption potential of alternative fuels in gas turbine power plants. Unlike conventional multi-criteria decision-making approaches, this method identifies the single most critical c...

The causal effect of drought on energy poverty

<title>Abstract</title> We use nationally representative panel data from rural areas and small towns in Ethiopia, matched with fine-resolution weather data, to investigate the impact of drought on energy poverty. Energy poverty is measured using the Multidimensional Energy Povert...

Toward federated large language models in medicine: a parameter-efficient framework for privacy-preserving, multi-institutional adaptation

Large language models (LLMs) are increasingly adapted for medical applications, but most are trained using data from a single institution because privacy and governance constraints prevent multi-institutional data sharing. As a result, these models often generalize poorly across...

A redox-regulated RCC1-like protein controls catalase activity in Arabidopsis

Abstract Reactive oxygen species (ROS) are central regulators of plant growth and stress responses. Cellular ROS levels are tightly controlled by antioxidant systems, including the evolutionarily conserved catalases that detoxify hydrogen peroxide (H 2 O 2 ) predominantly within...

Repetition Is Not Warrant: Register-Provenance Inheritance as a Deterministic Mechanism Against Laundering in Conversational Language-Model Records

A conversational language model system that verifies its claims against its conversation record contains a loop: the model asserts an unsupported proposition, the assertion enters the record, a later turn quotes it back, the quotation verifies, and the proposition now presents as...

Causal Memory Gravity II: Unified Cosmology and Galactic Dynamics with a DPN-Saturated SEM-RAR Response

Spiral galaxies rotate faster in their outskirts than Newtonian dynamics predicts from their observed baryons, and they do so with striking regularity. Once the baryonic acceleration gb is known, the measured acceleration follows a tight radial acceleration relation across galaxi...

Malignant Consciousness: A Cancerous Disease of Consciousness

Abstract This work is situated within the Preventive–Proactive Repression project (a multidisciplinary research project) and addresses the issue through a sociological analysis. This research article introduces the concept of cancer of consciousness: a cancerous condition that af...

Bivalve Gut Microbiome Responses to Sediment Characteristics and Anthropogenic Activities in Cerastoderma edule (Linnaeus, 1758)

Abstract Estuaries are dynamic ecosystems influenced by fluctuating environmental conditions and sediment-associated contamination, which may affect host-associated microbiomes. This study investigated the gut microbiome of the bivalve Cerastoderma edule across three estuarine si...

A Philosophical Framework of the Left-Hand Path

This paper develops a philosophical account of the Left-Hand Path from a critique of ontological grounding. It argues that distinction, although necessary for intelligibility, cannot be established as an intrinsic feature of reality without projecting the conditions of access ont...

Quantifying the role of nitrogen in achieving global Sustainable Development Goals

Abstract Achieving the 2030 Sustainable Development Goals (SDGs) requires balancing well-being with environmental protection, yet the role of nitrogen across these goals remains poorly understood. Here, we show how dietary nitrogen intake and nitrogen release to air and water are...

On the connection between zero-free regions and the error term in the prime number theorem

Abstract We provide for a wide class of zero-free regions an upper bound for the error term in the Prime Number Theorem, refining works of Pintz (1980), Johnston (2024), and Révész (2024). Our method does not only apply to the Riemann zeta function, but to general Beurling zeta f...

Cross modal reliable pixel contrastive learning for incomplete modal brain tumor segmentation

<title>Abstract</title> In clinical practice, Magnetic Resonance Imaging (MRI) often lacks specific modalities, inevitably leading to a degradation in predictive performance. Different modes are currently treated as independent and non-interfering during training for modal featur...

Towards unified AI-driven fracture mechanics: the extended deep energy method (XDEM)

Abstract Physics-Informed Neural Networks (PINNs) have recently emerged as powerful tools for solving partial differential equations (PDEs), with the Deep Energy Method (DEM) proving especially effective in fracture mechanics due to its energy-based formulation. Despite these adv...

Noise protected logical qubit in an open chain of superconducting qubits with ultrastrong interactions

To achieve a fault-tolerant quantum computer, it is crucial to increase the coherence time of quantum bits. In this work, we theoretically investigate a system consisting of a series of superconducting qubits that alternate between XX and YY ultrastrong interactions. By consideri...

Dynamic helical poly[4]helicene nanoribbon

<title>Abstract</title> The precise synthesis of helical graphene nanoribbons (GNRs) with a controlled handedness has a transformative potential as the promising chiral carbon materials. We now report the first synthesis of a dynamic helical poly[4]helicene nanoribbon, a novel cl...

Innovative active edible coating with safflower (Carthamus tinctorius L.) extract for microbial inactivation and shelf life extension of cheese

<title>Abstract</title> Edible coatings enriched with bioactive compounds represent a sustainable alternative to synthetic preservatives, offering both microbial safety and extended shelf life. This study introduces an active edible coating system based on whey protein isolate (W...