Research works

Targeting MDA5 induces immunogenic cell death and promotes anti-tumor immunity

Identifying targets to enhance tumor immunity is an urgent need. Although nucleic acid sensors play critical roles in promoting tumor immune clearance, their exceptionally low mutation rate in cancers suggests potential unexplored roles in tumor progression. Here, we demonstrate...

Safety evaluation of new energy three-electric systems using enhanced physics-informed neural networks

Accurate safety-state measurement of the three-electric system in new energy vehicles is essential for ensuring reliable and secure operation. This paper proposes an artificial-intelligence-assisted safety measurement framework that integrates a searchable encryption mechanism wi...

Ultrathin In2O3 shells enable chemically robust silver nanowire transparent heaters

Silver nanowire networks are attractive transparent-heater electrodes but are vulnerable to oxidation, sulfidation, and ion-assisted corrosion. Herein, an ultrathin indium oxide shell was grown directly on silver nanowire (Ag@In 2 O 3 NW) networks through a room-temperature, atmo...

Cross-arch biomechanical interaction between opposing maxillary rehabilitation and mandibular implants: a three-dimensional finite element analysis

Most finite element studies of full-arch implant rehabilitation evaluate a single dental arch and represent the opposing dentition as a prescribed load or simplified boundary. This approach does not directly capture the contribution of the opposing rehabilitation to load transfer...

A political-ontological perspective on pluriversal time

This article outlines a framework for understanding the relation between pluriversality and the temporalities of just transitions. We draw on political ontology, a field that examines conflicts between the modern ontology – grounded in the separation of humans from nature – and o...

Joint trajectories and associated characteristics of postpartum depressive and anxiety symptoms: a longitudinal study

Postpartum depressive and anxiety symptoms are common postpartum mental health issues, and these symptoms often co-occur. However, previous studies have primarily analyzed them separately, with limited evidence regarding their joint developmental trajectories and associated chara...

Cdc2-related kinases and cyclin partners as regulators of the Trypanosoma brucei cell cycle: Current evidence and unresolved questions

Trypanosoma brucei, the protozoan parasite responsible for African trypanosomiasis, undergoes a divergent cell cycle characterized by closed mitosis, inheritance of single-copy organelles such as the kinetoplast, basal body, and flagellum, and anterior-to-posterior longitudinal c...

Phylogenetic structure shapes body-mass variation in soil nematodes

Soil nematodes are abundant metazoans and widely used as bioindicators in terrestrial ecosystems, yet the influence of evolutionary history on their functional traits remains poorly understood. Here, we investigated whether phylogenetic relatedness structures body mass variation...

Gut guardians: the enteric neuroimmune-microbiota axis in health and disease

The enteric nervous system (ENS), the largest and most functionally complex division of the peripheral nervous system, orchestrates nearly all core gastrointestinal physiological processes. Accumulating evidence has established that the gut microbiota acts as a central upstream r...

Kinetic simulation of the glow curve and isothermal decay in the thermoluminescence of LiF:Mg,Ti: the spatially correlated trapping center/luminescent center model

The spatially correlated trapping center/luminescent center (TC/LC) kinetic model is used to simulate the relative intensities of glow peaks 4, 5a, 5 and 5b in the thermoluminescence (TL) of LiF:Mg,Ti as well as their isothermal decay from 0 to 900 s at 160 °C. The results show t...

Nicotine formulation and tobacco flavour in electronic cigarette aerosols differentially regulate alveolar epithelial barrier function and gene expression

Electronic cigarettes (ECs) are increasingly marketed as safer alternatives to conventional cigarettes, yet mounting evidence highlights that they are not without harm. In vitro air–liquid interface (ALI) models provide physiologically relevant systems to examine how EC aerosols...

Effect of mobile phone-based education on HIV self-testing knowledge and uptake among female sex workers in Nigeria

Female sex workers (FSWs) remain disproportionately affected by HIV infection, yet HIV testing uptake continues to be constrained by stigma, limited access to healthcare services, and inadequate knowledge of HIV prevention and self-testing approaches.= Mobile phone-based educatio...

Synergistic urea-assisted activation and nitrogen doping of biomass-derived porous carbon from coconut shell for high-performance supercapacitors

Biomass-derived carbon offers a renewable and low-cost route for fabricating advanced carbon-based supercapacitors. In this study, a cost-effective biomass precursor, coconut shell, was used to successfully prepare nitrogen-doped porous carbon materials through a synergistic modi...

Targeting Alzheimer’s disease pathways with Caralluma dalzielii: behavioural, biochemical, and molecular evidence from a transgenic Drosophila melanogaster model

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with limited disease-modifying therapies, necessitating the exploration of novel therapeutic agents. Caralluma dalzielii, a medicinal plant traditionally used for neurological disorders, has not previously been...

Use of methylene blue in the management of refractory shock in pediatric intensive care units: a nationwide assessment of clinical practice in Türkiye

This study aimed to evaluate previous clinical experience with methylene blue (MB), reported indications, dosing and administration preferences, monitoring and safety practices, and barriers to use among physicians working in pediatric intensive care in Türkiye. This national, cr...

The cultural evolution of play and magic dolls across 110 societies

Dolls represent one of the most widespread and enduring material objects that humans create across societies. The pervasiveness of dolls can offer novel insights into the role of human material culture in processes of cultural evolution. While commonly considered children's toys...

Clinical significance of intramammary lymph nodes in female primary breast cancer: a systematic review and meta-analysis

Intramammary lymph nodes (IntraMLNs), located within the breast parenchyma or axillary tail, are uncommon, and their clinical significance in primary breast cancer remains unclear. This meta-analysis evaluated the association between IntraMLN and axillary lymph node (ALN) status,...

Congenital Cytomegalovirus: The Time for a Unified Approach Is Now

Congenital cytomegalovirus (cCMV), the most common congenital infection in the United States, presents unique challenges to clinicians and families.Clinicians struggle to diagnose newborns in the first 21 days of life, when most newborns with cCMV are asymptomatic or have subtle...

Machine learning-accelerated sustainable inverse design of ultra-wideband THz metamaterial absorber

Terahertz absorbers are progressively relevant to sustainable energy and sensing where material and computational efficiency are essential. We demonstrated a six-layer IGIGIM (Insulator–Graphene–Insulator–Graphene–Insulator–Metal) metamaterial absorber that achieves >90% absorpti...

Enhancing learning health care systems with real-world data harmonization frameworks

The use of digital tools has enabled the capture of clinical data that can be leveraged to produce real-world evidence, complementing traditional trial data and addressing evidence gaps in oncology. Electronic health records offer rich, longitudinal data, although recording pract...