Research works

Evaluation of lens parameters using anterior segment optical coherence tomography for zonular weakness risk in cataract surgery

<title>Abstract</title> Zonular weakness leads to deviation or dislocation of the crystalline lens; however, studies on this topic remain limited. We aimed to evaluate crystalline-lens parameters for risk stratification of zonular weakness in patients undergoing cataract surgery....

An engineered Clostridial mini consortium modulates intestinal inflammation

Modern lifestyle factors have altered gut microbiota composition and function. Bacteria in the Clostridia class modulate mucosal immune responses through various mechanisms including production of secondary bile acids (SBA). Here, we present a novel system to study how the SBA is...

The SPATA5-SPATA5L1-CINP-C1ORF109 complex is essential for cytoplasmic pre-60S ribosome maturation

The ribosome is a universally conserved and essential molecular machine. While the core process of ribosome biogenesis is conserved across eukaryotes, metazoans have evolved additional regulatory factors. Here, we performed a protein–protein interaction screen of endogenously aff...

A pilot prospective study of tislelizumab and axitinib combined with stereotactic body radiation therapy for oligometastatic renal cell carcinoma

<title>Abstract</title> Background The aim of this study is to investigate the efficacy and safety of tislelizumab and axitinib combined with SBRT in the treatment of omRCC. Methods Eligible pts had oligometastases (≤ 5 leisions) and ≤ 1 prior systemic therapy. All patients recei...

CD8+ effector memory and regulatory T cell dynamics predict subclinical atherosclerotic plaque formation in healthy aging

<title>Abstract</title> Background Subclinical atherosclerotic plaque (SAP) develops silently in older adults. Early biological changes that predict plaque formation are not well defined. We examined whether immunological, and metabolic or functional measures identify vascular vu...

Structural Lemmas for the First-Prime Window of the Weil Quadratic Form

We prove six structural results for the local Weil quadratic form Q_W^L on L^2(-L,L) in the first-prime window (half*log2 < L < half*log3), the minimal interval where only the prime n=2 contributes to the Weil explicit formula. Our main technical contribution (Theorem 5.1) is an...

The Born–Infeld Saturation Margin of the Chiral Modulus: Antisymmetric Structure, Lorentzian Genus, and Electric Determination of the Generation Split

This note is the companion of the Projective Residue Schur reduction and takes up the first of its open deliverables: the definition of the Lorentzian saturation functional ${\mathcal{B}}(s)$ along the ${J_{\Pi}}$-odd modulus that controls the three-generation split coefficient $...

Toward an Intelligibility–Efficacy Framework: Psychological Timelessness and Existential Anxiety

Human beings appear uniquely capable of experiencing time psychologically rather than merely biologically. But the same cognitive capacities that permit long-term planning, autobiographical continuity, symbolic culture, and anticipation also expose the individual to chronic regre...

(10)The Imperishable Algorithm, Reincarnation, and the Fractal of Consciousness: The Mathematics of Individual Re-rendering within a Virtualized Matryoshka Universe (Paper X)

Based on the holographic principle and quantum information theory, this paper defines human individuality and its reincarnation as an engineering specification of the Universe OS. By extending the mathematics of black holes and information conservation (the Bekenstein-Hawking for...

Prehistoric pottery styles of the Jutland Peninsula and their effect on human attention

Abstract This paper examines how long-term transformations in pottery styles from the Jutland Peninsula (Denmark) may relate to patterns of visual attention between 4600 and 1 BCE. Free-viewing eye-tracking experiments were designed to record participants’ engagement with differe...

The Projective Residue as a Schur Complement: Reduction of the Generation Split to the Chiral Asymmetry of Projection Locking

The fermionic sub-programme of Cosmochrony locates the three-generation mass split in the $J_3$-odd part of the squared projective endomorphism $E_\Pi^2$ restricted to the gauge-singlet generation triplet ${C^3_{\mathrm{gen}}}$, parametrised by a single real number $u$ through $E...

The Fermionic Matter Sub-Programme

The fermionic matter sub-programme of the Cosmochrony corpus addresses a single central question: where do fermions, chirality, hypercharge, and three generations come from? The answer is that they are not postulated as external fields: they arise as the spinorial face of the adm...

What surrounds an injection decides whether it works: context and channel effects in tool-metadata attacks on seven production LLM agents. Data and code

A data and code for a study of indirect prompt injection in tool-using large language model agents. I performed 1,334 controlled trials across seven production models. In every comparison the injected instruction is held byte-identical and only its surroundings vary, so any diffe...

The Non-Injective Foundations Sub-Programme

This note presents the non-injective foundations sub-programme and corrects the status of its carrier-selection claim. The ENI no-go theorem establishes non-injectivity as a structural necessity of genuine emergence, while other constituent results address temporal ordering and d...

Interference-First Reality: A Variational Information-Geometric Framework for Emergent Objectivity, Time, Spacetime, and Gravitation

We introduce Interference-First Reality (IFR), a theoretical framework in which physical objectivity is not assumed as a primitive property of the world, but is derived as a stable multi-observer limit of an underlying interference structure. The fundamental object of the theory...

Symmetry-Broken Biphasic WS2 NanowhiskeredHeterostructures Enable Field-Induced NO2 Sensing

Abstract Van der Waals (vdW) materials have garnered ample interest as next-generation sensors and catalysts, owing to high surface-to-volume ratio, defect tunability, easy modulation of active sites, and convenience in device fabrication. However, one major drawback delimiting s...

The Cryptographic Horizon Model (Version 5)

Version 5.0 represents a major structural update to the Cryptographic Horizon Model, shifting the framework from conceptual theory to a rigorous mathematical specification. This document defines a novel, self-correcting thermodynamic state-machine model of cosmic evolution that c...

Projective Information Loss and Fibre Erasure in Admissible Non-Injective Projection

We establish a fibre-erasure theorem for the admissible coarse-graining hierarchy of the Cosmochrony spectral programme. The non-injective projection $\Pi: {\Omega} \to {\mathcal{O}}$ defines a residual fibre-information functional $I(c;\sigma(\ell))$, where $c$ is a Weil-block f...

FLOWRRA: Flow Recognition Reconfiguration Agent

Abstract—This paper presents FLOWRRA (Flow Recognition Reconfiguration Agent), a novel flow recognition and self reconfiguring cognitive architecture that redefines the agent-environment boundary through recursive autopoiesis and retrocausal flow regulation. FLOWRRA draws upon an...

Exact parameter-free sum rules for the Pontecorvo–Maki–Nakagawa–Sakata matrix from a split-and-recombined tribimaximal construction

We present an exact, fixed-input sum-rule construction for the Pontecorvo–Maki–Nakagawa–Sakata (PMNS) matrix: a deterministic ansatz combining a Koide–Brannen square-root mass-ratio input with a discrete split-and-recombined deformation of tribimaximal mixing (TBM), with every mi...