Research works

The impact of FTO and ADRB3 gene variants, physical activity and proper diet on weight gain and perinatal outcomes in pregnant women with obesity

This study aimed to evaluate the effects of FTO (rs9939609) and ADRB3 (rs4994) gene variants, dietary intervention, and physical activity on gestational weight gain and perinatal outcomes in women with obesity and early gestational diabetes (GDM). In this prospective study, 115 p...

Acoustic higher-order topological metals with bound corner states in the continuum

Two-dimensional topological insulators for first order and higher order, characterized respectively by in-gap edge states and corner states, have attracted tremendous research interest. Different from them, two-dimensional topological metals exhibit topological boundary states in...

Development of a 1D Model and Performance Analysis at Extremely Low Temperature of an R290 Indirect Heat pump System with Vapor-Injection

Propane (R290) is a promising alternative refrigerant for electric vehicle (EV) heat pumps, particularly with tightening regulations on PFAS. This study developed a 1-D GT-SUITE model of an R290-based indirect heat pump system (IDS-HP) to investigate the effect of vapor-injection...

The Relationship Between Educational Level and Cognitive Function in Older Adults: Focusing on the Pathways of Social Participation and Depression

교육수준과 인지기능 간의 관련성은 반복적으로 보고되어 왔으나, 사회참여와 우울이라는 서로 다른 심리사회적 경로를 하나의 모형에서 동시에 검증한 연구는 제한적이다. 본 연구는 노인의 교육수준과 인지기능 간의 관계에서 사회참여와 우울의 병렬 매개모형을 적용하여 사회참여와 우울의 간접경...

Applying the mastery-engagement matrix in asynchronous first-year library instruction

This study investigates the relationship between asynchronous library video tutorial engagement and information literacy mastery among 707 first-year university students. Adopting a quantitative methodological approach, this study utilizes Springshare's LibWizard for formative as...

The Therapeutic Potential of Ketamine as a Treatment for Amyotrophic Lateral Sclerosis: A Narrative Review Focusing on Sigma-1 Receptor Modulation, Mitochondrial Function, and Neuroplasticity

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive motor neuron degeneration. Current Food and Drug Administration (FDA)-approved treatments provide only modest benefits and do not substantially alter disease trajectory, un...

Development and validation of the “Yucan-1” 5 K liquid chip for genomic studies in the silkworm (Bombyx mori)

The silkworm ( Bombyx mori ) is a lepidopteran model of paramount economic and scientific importance. While genomic resources are available, a high-throughput, cost-effective, and breed-specific genotyping platform for targeted genetic studies in Chinese local breeds, particularl...

Clinical-guided deep learning framework for diabetic retinopathy: integrating lesion-aware attention, adversarial augmentation, and uncertainty quantification

The global prevalence of diabetic retinopathy (DR) is increasing in parallel with the rising burden of diabetes, posing a substantial public health challenge. Current automated DR screening systems often lack lesion-level interpretable, robustness against class imbalance, and rel...

Single-Chain Persistence Theory II: The Mathematical Foundations of Persistence

This paper is the mathematical middle layer between Single-ChainPersistence Theory I (SCPT-I) and Single-Chain Persistence Theory III (SCPT-III) . SCPT-I bears the burden ofproof; the present paper formalizes the four criteria and answers the question “why the fourcriteria can be...

Clear cell Paget disease with underlying malignancy: A case report and review of literature

Paget's disease of the breast (PDB) is a rare form of breast cancer, characterized by the existence of Paget cells. It accounts for nearly 1%-3% of all breast cancers. Glycogen-rich clear cell ductal carcinoma in situ (DCIS) of the breast is an infrequent occurrence. The current...

A Longitudinal Analysis of Media Discourses on Social Isolation and Digital Device Use among Older Adults: A Critical Discourse Analysis Using BIGKinds

노인의 사회적 고립은 노인의 건강 악화 및 사회적 비용을 증가시키는 사회 문제로서 대두되고 있다. 코로나19가 유행하며 디지털 전환의 가속화는 노인의 디지털 격차와 사회적 고립 문제를 심화시켰다. 이에 본 연구는 노인의 디지털 사용과 사회적 고립에 대한 키워드 및 담론의 구조와 변화 양상을...

Magnetically modified orange peel powder: A sustainable and recoverable adsorbent for enhanced removal of Rhodamine B

Orange peel powder (OPP) has been widely explored for dye adsorption; however, its limited adsorption capacity and poor separation efficiency restrict its practical applicability. In this study, magnetic Fe 3 O 4 nanoparticles were successfully integrated with OPP through a green...

Effects of vegetarian or vegan diets on cardiovascular metabolic health in patients with cardiovascular disease: a systematic review and meta-analysis

Vegetarian or vegan diets have been associated with favorable cardiovascular outcomes in the general population; however, their effects on cardiometabolic risk factors in patients with established cardiovascular disease (CVD) remain unclear. This systematic review and meta-analys...

RAF1 extrachromosomal DNA amplification confers acquired erlotinib resistance in a non-small cell lung cancer cell model

EGFR (epidermal growth factor receptor)-targeted therapies, which utilize small molecule inhibitors such as erlotinib and osimertinib to inhibit aberrantly activated EGF receptors caused by oncogenic mutations such as L858R and exon 19 deletion occurring primarily in the region c...

Improving sepsis best practice utility and clinical acceptance using an LLM-enhanced prediction system

Early detection of sepsis is essential for reducing mortality, but diagnosis can be delayed because symptoms of sepsis are often non-specific, frequently mimic other conditions and differ between individuals. We implemented COMPOSER-LLM, an enhanced sepsis prediction system that...

Primary prevention of child sexual abuse with preschool children in Portugal: A pilot feasibility trial of the CARE program

Background Child sexual abuse (CSA) is a major public health concern, yet rigorously evaluated and fully manualized primary prevention programs for preschool children remain scarce. Evidence on the feasibility and acceptability of such interventions among young children and their...

Molecular mechanism of drought resistance in oat roots revealed using integrated physiological and multi-omics analyses

Oat ( Avena sativa L.), a key forage crop, is highly susceptible to water deficit. Many studies have elucidated the mechanisms through which oat leaves respond to drought; however, little is known about these mechanisms in roots. We compared the physiological, transcriptomic, and...

Mitochondrial Haplogroup U and multiple sclerosis risk in Arab and Near Eastern populations: a systematic review and meta-analysis

Multiple Sclerosis (MS) is an inflammatory neurodegenerative disease with incompletely understood aetiology beyond the HLA-DRB1 locus. Mitochondrial haplogroup U, prevalent in Middle Eastern and Near Eastern populations, encodes functional variants in NADH dehydrogenase subunits...

The Impact of Safety Practice Behaviors on Safety Protection among Participants in Senior Employment Programs: Focusing on the Moderating Effect of Perceived Effectiveness of Safety Education

노인일자리가 확대되고 있는 상황에서 참여자 특성과 다양한 작업환경 등으로 인한 안전사고 위험이 내재되어 있다. 이에 본 연구는 2025년 노인일자리 및 사회활동 지원사업 실태조사 자료를 활용하여 노인일자리 참여자의 안전실천행동이 안전보호에 미치는 영향에서 안전교육 효과성 인식의 조절효...

Framing Older Adults’ Digital Literacy in Korean News Media: A Critical Discourse Analysis Through the Lens of Active Ageing 2.0

디지털 전환이 가속화된 사회적 맥락에서, 본 연구는 국내 언론이 노년층의 디지털 리터러시를 어떠한 의미 구조와 주체성의 틀로 재현하는지를 탐색하였다. 연구의 이론적 기반으로 WHO가 제시한 능동적 노화 2.0의 핵심 가치인 기능적 능력, 사회적 포용, 디지털 시민성을 설정하고, 2020년 이후 보...