Research works

Environmental sustainability mediating adaptive marketing capability and performance of manufacturing firms in emerging markets

While sustainability has emerged as a critical mega-trend reshaping business strategies worldwide, little is known about how adaptive marketing capabilities foster corporate environmental sustainability and whether these capabilities translate into improved firm performance. This...

Exosomes in brain diseases: Mechanisms, advances, and perspectives

The blood–brain barrier (BBB) remains a major biological obstacle limiting the effective delivery of therapeutics for central nervous system (CNS) disorders. Although conventional drug delivery approaches have achieved continuous advances, their clinical translation is frequently...

Global trade-offs between consumption, carbon prices and equity

As the remaining carbon budget continues to dwindle, economic growth strains efforts to limit global warming to 1.5 °C. Reducing unnecessary production and consumption in high-income regions and among the wealthy, and organising production more around human needs and human well-b...

Celebrating the nation’s 250th: America’s first hospital pharmacy

Compounding drugs, seeking operational funding, and administering medications to patients. The nation’s earliest hospital pharmacists shared some duties with today’s pharmacists—though they were also, literally, pulling teeth. To mark the nation’s 250th anniversary, the ASHP News...

Ligase enzymes for the synthesis of peptide therapeutics

Peptides are widely used as therapeutics and in many other important applications. However, current chemical synthesis of peptides is highly step- and atom-inefficient, requiring deleterious reagents and solvents, which creates harmful waste. Alternative methods for more sustaina...

AI-guided De Novo design of DHPS inhibitors

Hypusine modification of eIF5A by Deoxyhypusine Synthase (DHPS) is essential for the replication of a broad range of viruses, making DHPS an attractive host-directed therapy (HDT) target for antiviral drug discovery. AI-based drug design methods spanning binding affinity predicti...

Clinical and pathological characteristics of mucinous adenocarcinoma in colon cancer: comparison with classic adenocarcinoma

Mucinous adenocarcinoma of the colon is defined by extracellular mucin occupying at least 50% of the tumour. Although it is often regarded as a distinct histological subtype, its clinicopathological profile remains variable across published series. We compared mucinous and classi...

Prediction of plutonium content of BWR/MOX fuel using a neural network

The Nuclear Material Balance (NMB) code is a comprehensive nuclear fuel cycle simulator developed by the Institute of Science Tokyo and the Japan Atomic Energy Agency. By modeling a fleet of reactors, fuel cycle simulators like NMB can help to optimize uranium and plutonium utili...

MXene as conductive mortar: Assembly of Ti3C2Tx and carbon nanotube fibers into multifunctional films for EMI shielding and infrared stealth

Advanced electronic and defense systems require multifunctional films that combine electromagnetic interference (EMI) shielding and infrared (IR) stealth with mechanical robustness, high electrical conductivity, and low IR emissivity. Here, we report a mechanically strong and hig...

Dietary behaviour of Sepedon (Parasepedon) ruficeps and Sepedon (Sepedomyia) nasuta (Diptera: Sciomyzidae) and the distribution of their snail prey in Benin (West Africa)

Sciomyzidae (Diptera) larvae live as predators and/or parasitoids of snails. They have potential economic importance as biological control agents against gastropods that are vectors of parasitic diseases. In the present study, the use of Sepedon larvae in schistosomiasis control...

Telmisartan for Apolipoprotein E ε4 Carriers as a Candidate Precision Medicine Strategy in Alzheimer’s Disease

The apolipoprotein E ε4 (APOE ε4) allele is the strongest common genetic risk factor for late-onset Alzheimer’s disease and is associated with blood–brain barrier (BBB) dysfunction, cerebrovascular instability, impaired lipid transport, and metabolic dysregulation. These features...

Interplay between sports nutrition knowledge, lifestyle factors, and body mass index among regularly exercising university students: a cross-sectional study

This study aims to comprehensively examine the complex relationships among sports nutrition knowledge, nutritional status (macro- and micronutrient intake), body mass index (BMI), and lifestyle factors (smoking status, dietary habits including salt preference, daily water consump...

Panniculitis masquerading as generalised lymphadenopathy in a neonate: a diagnostic dilemma – a case report and a mini review

Generalised lymphadenopathy is rare in neonates and often suggests a serious systemic illness, including malignancy, immune dysregulation or congenital infection. Panniculitis is not commonly considered as a differential diagnosis in this age group. This case report highlights th...

Effects of Physical Exercise on Fall Risk in Patients With Parkinson’s Disease and Other Forms of Parkinsonism: An Overview of Systematic Reviews

Falls are among the most important causes of preventable morbidity in older adults worldwide. The objective of this review is to evaluate whether exercise-based interventions, compared with non-exercise or other physical activity interventions, reduce fall risk in community-dwell...

Robust Control of Variable Speed Refrigeration System by Simplified Model Reference Adaptive Control Applying Pre-filter

This paper aims to design a simplified model reference adaptive controller (S-MRAC) with pre-filters for robust, high-precision control of a variable-speed refrigeration system (VSRS) amidst model uncertainty and disturbances. The S-MRAC is based on the MIT rule, utilizing parame...

Nano-silicon and regulator treatments unlock genotype-specific growth and yield responses in durum and common wheat under field conditions

Enhancing wheat productivity under real-world field conditions remains a major challenge for sustainable agriculture. Silicon-based amendments and plant growth regulators have shown promise in improving crop performance, yet their comparative effectiveness across contrasting whea...

Association between PCSK9 and post-stroke cognitive impairment: a retrospective cohort study and predictive models establishment based on machine learning

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has gained increasing attention due to its involvement in lipid metabolism and neuroinflammation regulation. High PCSK9 levels are linked to an elevated risk of cerebrovascular events and small vessel diseases. However, system...

Citrullination-associated transcriptional states identify a non-canonical invasive program in malignant epithelial cells and correlate with SPP1-CD44 immune microenvironment niches in thyroid cancer

Background Citrullination, a post-translational modification catalyzed by protein arginine deiminases (PADIs), has been implicated in malignant progression across multiple cancer types. However, its cellular distribution, functional significance, and role in microenvironment remo...

A structured framework for standardizing lifestyle data: core data interoperability (CDI) model with expert validation

Lifestyle factors, such as smoking, alcohol consumption, and physical activity, are among the most critical modifiable risk factors for morbidity and mortality; however, their representation in health data remains inconsistent and unstructured. Although electronic medical record...

Comparing the Latent Structure of Digital Literacy Between the Young-Old and the Old-Old During the Pandemic: A Latent Profile and Latent Transition Analysis

본 연구는 팬데믹 시기 전기 노인과 후기 노인의 디지털 문해력 구조와 변화 양상을 검증하였다. 한국미디어패널 2020년과 2022년 자료 중 만 65세 이상 2,070명(전기 노인 1,108명, 후기 노인 962명)을 대상으로 잠재프로파일분석을 실시하고, 안정적 유형이 도출된 전기 노인에 대해 잠재전이분석을...