Research works

Vaccinia-related kinase 2 confers pancreatic cancer with gemcitabine resistance through TPI1-driven aerobic glycolysis

Abstract Gemcitabine(GEM)-based chemotherapy is considered the first-line regimen for pancreatic cancer(PC), but the poor responsiveness and chemoresistance greatly limit its application. Metabolic reprogramming, especially aerobic glycolysis, which is regulated by glycolytic enz...

Therapeutic Equivalence, Immunogenicity, and Safety of Euvichol Oral Cholera Vaccine Formulations Compared with WHO-prequalified Shanchol vaccine in Healthy Children and Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Preprint Description Background: Global demand for oral cholera vaccines (OCVs) has increased substantially, while the discontinuation of Shanchol has increased reliance on Euvichol-based formulations. This systematic review and meta-analysis evaluated the immunogenicity and safe...

Effectiveness of a Personalized Robot-Assisted Trunk and Lower Limb Rehabilitation in Patients with Chronic Stroke

OBJECTIVE: To investigate the clinical effectiveness of a newly developed trunk-lower limb rehabilitation robot in patients with chronic stroke. DESIGN: Randomized controlled trial conducted at a rehabilitation center. Forty patients with chronic stroke (mean age 59.48±7.63 years...

Magnetic Resonance Imaging Evaluation of Meniscal Ramp Lesions and their Association with Anterior Cruciate Ligament Injury Severity: A Retrospective Observational Study

Abstract Background: Meniscal ramp lesions are frequently associated with anterior cruciate ligament (ACL) injuries and are often overlooked on magnetic resonance imaging (MRI). Their relationship with the severity of ACL injury remains incompletely understood. Objective: The pur...

In-Field and Out-of-Field Teachers Incorporating a bMOOC in Physics Classrooms: Challenges and Opportunities

Abstract Out-of-field (OOF) teaching is a persistent challenge in secondary school physics, where effective instruction requires strong content knowledge (CK) and pedagogical content knowledge (PCK). Digital resources are often proposed as support, yet little is known about how t...

The Invariance Capacity Ceiling: Forbidden-Proxy Alignment Caps Predictive Information

Proof-reconciled generated exploration of a finite representation-capacity ceiling under forbidden-proxy mutual-information leakage. This public working-corpus release includes the reviewed manuscript and paired Lean evidence. It is not peer reviewed or empirically validated; sig...

Pineoblastoma in a 5-Year-Old Male: A Case Report and Review of Literature

Abstract Pineoblastoma (PB) is a rare malignant embryonal tumour arising from the pineal gland. It commonly affects the paediatric age group with a slight male predilection. The typical clinical features include symptoms and signs of raised intracranial pressure, but extracranial...

Role of the School Nurse in Providing School Health Services: Policy Statement

School nursing has evolved into an essential field bridging health care and education. School nurses play multifaceted roles, addressing direct care, care coordination, public health, leadership, and quality improvement. They manage communicable diseases, chronic conditions, ment...

Pre-registration: L-band detection of alternate wetting and drying in a Balinese subak (Subak Kloncing, Bali, Indonesia)

This deposit states, in advance of the observations that would test it, what would count as satellite detection of alternate wetting and drying (AWD) in a smallholder rice landscape. Subak Kloncing, Bali, has 32 farmers enrolling 1.63 ha of AWD within a 101 ha subak — median plot...

Proof of T-duality within Euclid's Geometry

Euclidean geometry contains an exact duality of scale. For the round 2-sphere S2R of radius R, both ends of the scale parameter R carry the Euclidean plane: as R → 0 the sphere collapses to a point whose tangent plane is Euclidean, and as R → ∞ the local geometry is Euclidean. Th...

Simultaneous removal of methylene blue and Cd(II) by pecan shell–based activated carbon: adsorption kinetics, isotherms, and physicochemical characterization

The coexistence of organic dyes and heavy metals in wastewater requires efficient and sustainable adsorbents capable of simultaneous contaminant removal. In this study, pecan shell–based activated carbons (PSC-0–PSC-3) were prepared by KOH activation using different impregnation...

Beyond the Race for Smarter AI: Toward Standards for AI Capability, Dependability, and Human-AI Capability Continuity

The present phase of artificial intelligence is characterized by an intense competition for cognitive capability. Vendors compare models by reasoning, knowledge, coding, planning, and increasingly agentic performance. Yet the historical role of standardization in computing sugges...

Efficacy and safety of concomitant catheter ablation and left atrial appendage closure compared to catheter ablation only – a meta-analysis

Abstract Background Atrial fibrillation (AF) carries a substantial ischemic stroke risk originating predominantly from the left atrial appendage (LAA). Catheter ablation (CA) is the most effective rhythm-control strategy, while percutaneous LAA closure (LAAC) provides mechanical...

Chronic traumatic popliteal arteriovenous fistula presenting twenty years after shotgun injury: a case report and critical literature review

Traumatic arteriovenous fistulas (AVFs) account for only 2.5–4% of penetrating vascular injuries, yet their natural history is insidious: most remain hemodynamically compensated for years before clinical decompensation. Delayed popliteal AVF poses unique diagnostic and therapeuti...

Early Outcomes of Open Tibial Shaft Fracture Management at a Tertiary Orthopaedic Hospital in Nigeria: A Prospective, Observational Study

Abstract Background: Management of open tibial shaft fractures in resource-poor settings presents significant challenges, yet prospective data on treatment outcomes in Sub-Saharan Africa remain limited. These injuries, often resulting from high-energy trauma, carry substantial ri...

The Symbiotic Bandwidth Bound: Low-Rank Shared Channels Cannot Remove Worst-Case Thermodynamic Speed Limits

Proof-reconciled generated exploration of low-rank shared mobility channels under a bounded quadratic model. This public working-corpus release includes the reviewed manuscript and paired Lean evidence. It is not peer reviewed or empirically validated; significance and novelty ha...

High-Value Care in Pediatric Critical Care: Intravenous to Enteral Gastrointestinal Medications

Advancing pediatric critical care medicine includes identifying and reducing health care costs while maintaining—and even enhancing—the delivery of high-value care. Gastrointestinal (GI) prophylaxis (PPX) is commonly prescribed for children in the pediatric intensive care unit (P...

Time-dependent analysis of HUS change in older patients aged > 75 years with head and neck cancer

Previous longitudinal evidence has suggested that patients aged > 75 years may be associated with a poorer Health Utility Index Mark 3 (HUI-3) trajectory. We compared the longitudinal health utility scores (HUS) of older (>75 years) versus younger patients with head and neck canc...

Prostatic Androgen Receptor Expression in Men with Prostate Cancer

Abstract Background: Prostate cancer is the second most commonly diagnosed cancer in men worldwide. There has been a stage migration among the population with PCa in developed countries since the introduction of the tumor marker, prostate-specific antigen. It has also been found...

Antimicrobial stewardship in practice: determinants of prescription behaviour and developing interventions to improve surgical prophylaxis in a Rwandan tertiary hospital—a mixed methods study using the behaviour change wheel

BACKGROUND: Behavioural sciences should be used to design and improve antimicrobial stewardship (AMS) interventions aiming surgical prophylaxis (SP). METHODS: A mixed-methods study at the University Teaching Hospital of Kigali, Rwanda. The study included an audit on SP practices...