Research works

A ROS-Responsive Photothermal Hydrogel for Tumor Microenvironment Reprogramming and STING-Mediated Immune Engagement

Photothermal therapy can induce local tumor cell death and trigger antitumor immune responses. However, its efficacy is often limited by insufficient lymph node immune priming and by sustained ROS generated from thermal stress, which suppress immune cell function. An oxidative-st...

Token Economy Optimization: Reducing LLM API Costs Without Sacrificing Output Quality

Research article: Token Economy Optimization: Reducing LLM API Costs Without Sacrificing Output Quality

Genome-Wide Identification, Evolutionary Analysis and Comprehensive In Silico Characterization of the GPAT Gene Family in Sunflower (Helianthus annuus L.)

Glycerol-3-phosphate acyltransferase (GPAT) are enzymes involved in glycerolipid biosynthesis and play a key role in plant growth, development, and abiotic stress responses. However, a comprehensive genome-wide and in silico analysis of the GPAT gene family in sunflower (Helianth...

A review of heating mechanisms, process parameters, and defect-minimized densification applications of microwave sintering in metals

Microwave sintering, an advanced materials processing technique, has garnered substantial attention due to its distinctive heating mechanism, which facilitates more uniform and efficient heating of materials, such as metal powders. This study constructs a comprehensive analytical...

Egyptian cotton: harnessing genetic diversity, molecular tools, fiber anatomy, and innovation for a climate-smart future

Abstract Egyptian cotton, derived primarily from Gossypium barbadense L., has shaped the country’s agricultural economy and international reputation for nearly two centuries. Among these, the Giza varieties—renowned for their exceptional fiber length, fineness, and strength—have...

Pacemakers in Pediatric Patients

Pacemaker insertion in children presents unique challenges because of their small size and developing anatomy. Since pacemaker insertion is relatively uncommon in pediatric patients, and as a result, specialized technologies for this population remain limited and under-researched...

Differentiation of plant adaptive strategies on the Jingpo Lake lava plateau: a comparison of leaf and absorptive root functional trait spectra across different life forms

Focusing on the highly heterogeneous habitat of the Jingpo Lake lava plateau, this study quantified 24 above- and below-ground functional traits across 12 dominant species. Transcending the conventional single-organ perspective, we investigated whether environmental stress drives...

Beyond methodological fidelity: emotional intelligence as the relational infrastructure of agile project management

Purpose Agile methodologies have proliferated across project-based industries, yet scholarly discourse remains oriented toward procedural and technical dimensions. This study challenges the prevailing technocentric bias by investigating how emotional intelligence (EI) shapes agil...

Termination Behavior Across Fixed-Prefix Interface Conditions in a Single 4B QLoRA-SFT Lineage: Termination Rates, Early Stop Mass, and Endpoint Saturation Under Prompt-Loss-Weight Manipulation

Corrected technical preprint, version 1.1. English is the primary version; a faithful Japanese companion version and both supplements (EN/JA) are included. This version supersedes v1.0 (DOI 10.5281/zenodo.21967093), whose files were restricted after a premature release. The corre...

Investigation of the Structural, Geometric, Spectroscopic, and Nonlinear Optical Properties of (E)-2-(2,4-dihydroxybenzylidene) thiosemicarbazone and (E)-2-[(1H-indol-3-yl)methylene] thiosemicarbazone complexes: A DFT Study

The optimized molecular geometries, vibrational frequencies, and both ¹H and ¹³C NMR spectra of (E)-2-(2,4-dihydroxybenzylidene)thiosemicarbazone (1) and (E)-2-[(1H-indol-3-yl)methylene]thiosemicarbazone (2) complexes were investigated using density functional theory (DFT) method...

The Seed-Source Bottleneck Certificate: A cut condition for climate-aligned afforestation supply networks

Proof-reconciled generated exploration applying an established capacitated Hall/min-cut construction to declared seed-routing inputs. This public working-corpus release includes the reviewed manuscript and paired Lean evidence. It is not peer reviewed or empirically validated; si...

Solitary Intraosseous Neurofibroma of the Mandible: A Case Report

Abstract Background Solitary intraosseous neurofibroma of the mandible is a rare benign peripheral nerve sheath tumor. Owing to its low incidence and nonspecific clinical and radiographic features, diagnosis can be challenging. We report a rare case with extensive mandibular dest...

Elevated Serum Renin Before Liver Transplantation Is Associated With Increased Intraoperative Vasopressor Requirements and Posttransplant Acute Kidney Injury

BACKGROUND: Derangements of the renin-angiotensin-aldosterone system may contribute to circulatory dysfunction in cirrhosis. We hypothesized that renin is elevated in patients undergoing liver transplantation (LT) and is associated with vasopressor requirements and postoperative...

QGD / MPDT and Poincaré–Weyl Predicativism: Independent Convergence, and Why Physical Grounding Reaches Further

Physical constructivism — the position that a mathematical object exists only when a physical process has completed its construction, that notation for a never-terminating process is a prescription rather than a name, and that the set of existing numbers is bounded by the physica...

Following the rules: which type 1 diabetes guidelines, protocols and recommendations are tertiary clinics in Australia following? A quantitative study

OBJECTIVES: This study characterises the use of type 1 diabetes (T1D) guidelines and protocols in Australian T1D clinics working with paediatric patients, and determines if management practices align with T1D-specific guidelines. METHODS: T1D clinic service leaders responded to a...

Pharmacokinetic and pharmacodynamic sub-study of trans-arterial vs. intravenous gemcitabine in the TIGeR-PaC phase 3 clinical trial

Abstract Purpose Localized intra-arterial delivery of gemcitabine (IAG) may provide advantages in terms of increased tissue concentration and decreased systemic dosing. We hypothesized IAG may result in decreased systemic gemcitabine concentration and associated side effects due...

Proofs of Nothing: Zero-Witness Forgeries and the Side Conditions That Prevent Them

A lattice proof verifier is sound only if it binds the proof to a fixed statement the prover cannot choose. We report a post-quantum consensus verifier that does not, and accepts a proof of nothing. In a confidential-transaction opcode, an all-zero proof whose only nonzero field...

The Invariance Capacity Ceiling: Forbidden-Proxy Alignment Caps Predictive Information

Proof-reconciled generated exploration of a finite representation-capacity ceiling under forbidden-proxy mutual-information leakage. This public working-corpus release includes the reviewed manuscript and paired Lean evidence. It is not peer reviewed or empirically validated; sig...

Optimising Anaesthesia Care for Open Abdominal Myomectomy: A Decade-Long Retrospective Analysis from a Nigerian Hospital

Abstract Background: Anaesthesia for open abdominal myomectomy is customised to provide a comfortable and pain-free surgical experience for the patient, taking into consideration their medical history, personal preferences and the results of the pre-anaesthesia assessment. Object...

Variation in In-Hospital Emergency Transfer Rates Across Pediatric Hospitals

BACKGROUND: Clinical deterioration with late escalation, termed emergency transfer (ET), is a key safety metric. However, national benchmarking is limited by variable definitions. We sought to estimate pooled ET rates and assess variation across pediatric hospitals. METHODS: We p...