Research works

General Theory of Embedded Spaces: Formalization of Projective Transitions

In previous works by the author, a classification of types of spatial embedding was introduced: division (a brane as a partition dividing space into half-spaces) and enclosure (a closed surface surrounding an interior region). It was shown that SFS as an ∞D-subject is located "ou...

Closure Mathematics Quotient Disclosure, Closure Compression, Predictive Completion, and Reconstruction-Preserving Representation

This publication version is a reconstruction-preserving compression of a much larger developmental corpus. Established mathematical substrates are explicitly separated from framework synthesis and from optional physical interpretations. The paper does not identify mathematical fi...

The Anytime Change Certificate: False-alarm control, a late-change penalty, and a bounded erasure budget for continuous monitoring

Proof-reconciled generated exploration of a heavy-tailed anytime-valid change-time mixture with explicit iid/model-mismatch controls and model-limited erasure accounting. This public working-corpus release includes the reviewed manuscript and paired Lean evidence. It is not peer...

IMPROVING GRADE 4 PUPILS’ WRITING SKILLS THROUGH A GENRE-BASED APPROACH AT BURGOS CENTRAL SCHOOL

This action research investigated the effectiveness of the Genre-Based Approach (GBA) in enhancing the writing skills of Grade 4 pupils. Based on the Teaching-Learning Cycle (TLC), the approach features explicit instruction, teacher scaffolding, collaborative learning, and indepe...

Hemoglobin-Red Blood Cell Distribution Width Ratio (HRR) and Rheumatoid Arthritis Risk: A Population-Based Study from the NHANES

Abstract Background: Rheumatoid arthritis (RA) is a prevalent autoimmune disease with a substantial health burden. The Hemoglobin-red cell distribution width ratio (HRR) is a novel inflammation-related biomarker, yet its association with RA risk remains unexplored. Aims: This stu...

Women’s Experiences of Discrimination and Their Success Expectations in Higher Education: Evidence from Gendered Fields of Study

Abstract Women’s underrepresentation in male-dominated fields of study is often attributed to a gender gap in success expectations. Prior research shows that female students report lower confidence in their academic abilities and future success than men, not only in male-dominate...

General Theory of Embedded Spaces: Formalization of Projective Transitions

In previous works by the author, a classification of types of spatial embedding was introduced: division (a brane as a partition dividing space into half-spaces) and enclosure (a closed surface surrounding an interior region). It was shown that SFS as an ∞D-subject is located "ou...

Consciousness, Timelessness and the Structure of Experience: A Philosophical Essay

The brain lives in time. Consciousness does not — and that difference changes everything. The brain is a temporal, entropic organ embedded in spacetime; consciousness is a timeless, unified field that does not fragment, decay, or age. These two structures cannot belong to the sam...

Smart Lithotripsy: Lasers, Energy Sources and Efficiency

PURPOSE OF REVIEW: To examine the evidence on contemporary lasers and provide a practical framework for platform selection, parameter optimization, and thermal safety based on the principles of smart lithotripsy. RECENT FINDINGS: Holmium: yttrium-aluminum-garnet (Ho:YAG) remains...

The Inv(16) Oncogene CBFB::MYH11 is Required for the Survival of Leukemia Cells in the Blood and Spleen, but not the Bone Marrow

Inversion of chromosome 16 [inv(16)] generates the fusion gene CBFB::MYH11 (CM) and is one of the most common chromosomal rearrangements in Acute Myeloid Leukemia (AML). Expression of CM is required for leukemia initiation. Patients with inv(16) at diagnosis invariably have the r...

Comparative Evaluation of Virtual Reality versus Standard Nursing Care in Managing Pain and Fear during Lumbar Puncture Procedures: A Randomised Controlled Trial

Abstract Background: Meningitis is a serious infectious disease that can cause significant morbidity and long-term neurological problems. Although a lumbar puncture is a necessary diagnostic procedure, it is often accompanied by discomfort, anxiety, and fear, which can severely i...

Agranulocytosis associated with metamizole among EudraVigilance reports involving methotrexate for rheumatoid arthritis

Methotrexate (MTX) can induce adverse drug reactions (ADRs) including severe haematotoxic events. This study analyses whether agranulocytosis is disproportionately reported in spontaneous reports involving MTX for rheumatoid arthritis (RA) when use of metamizole, a non-opioid ana...

Disproportionate expansion of radical prostatectomy among older men in Japan in the robotic surgery era: a nationwide descriptive time series analysis

Abstract Robot-assisted radical prostatectomy (RARP) has rapidly expanded and become the leading surgical approach for prostate cancer in Japan. However, it remains unclear whether the concurrent increase in radical prostatectomy reflects population aging, increased diagnostic ac...

A Practical Guide to Mixed-Effects Models for Clustered Data in Pediatric Research

Clustered data, in which observations are grouped within higher-level units, arise frequently in pediatric research. Common examples include repeated measures within patients and patients nested within hospitals. Observations within the same cluster tend to be correlated, and sta...

Continuous Publishing as Next Step in Continuous Improvement at Hospital Pediatrics

We are excited to announce that Hospital Pediatrics has moved to a continuous publishing model. What is continuous publishing? It is a relatively new model in which articles are published shortly after acceptance versus the historical model of publication occurring when space was...

Viscoelasticity-guided covalent assembly of atomically precise nanoclusters via nitrene-mediated two-photon lithography

The translation of atomically precise metal nanoclusters into functional macroscopic devices is restricted by the difficulty of scaling manufacturing while preserving fragile quantum structures. Although two-photon lithography offers a route for micro-fabrication, the absence of...

The Intent Bottleneck: When AI Compresses Delivery, Strategy Becomes the Constraint

This working paper argues that AI-native delivery compresses only the final stage of a six-stage chain running from an institution's covenant with those it serves to running software, so that by Amdahl's law the constraint moves upstream into how organisations form, prioritise, a...

From Primitive Observation Records to the Dual-Axis Axiom: Set-Theoretic Foundations of Observational Geometry

The problem considered here arose in information science: the relation that forms an observation need not remain fixed while the underlying state of interest is held fixed. Yet the argument begins before any particular information-theoretic, statistical, geometric, or physical mo...

Physics-informed neural networks for modeling infiltration and solute transport in porous media

This thesis addresses forward and inverse modeling of water infiltration and solute transport in porous media by developing efficient physics-constrained computational numerical models. For the mathematical description of water infiltration, two formulations are considered: the s...

Psychological Safety and Question-Friendly Organizations: A Working Paper on Permission, QRI, and the APS Model

This text explores the importance of questions in organizational life, using Psychological Safety as its point of departure. In recent years, Psychological Safety has gained increasing attention as an essential condition for open communication and organizational learning. However...