Research works

Analysis of molten particles from the Moto-Ujina Beach, Hiroshima

Abstract Color-sorted spherical molten particles extracted from Moto-Ujina Beach sand were analyzed by inductively coupled plasma–mass spectrometry, thermal ionization mass spectrometry, micro-PIXE analysis to obtain the elemental concentrations, 235 U/ 238 U isotope ratios, and...

Adolescent environmental enrichment prevents early-life stress-induced schizophrenia-like phenotypes via restoration of CREB-BDNF-TrkB signaling

Early-life stress (ELS) is a major environmental risk factor for schizophrenia, yet effective preventive strategies targeting its neurodevelopmental consequences remain limited. Here, we show that adolescent environmental enrichment (EE) prevents the emergence of schizophrenia-li...

Multi-Pass Sentence Cloze Infilling with Sigmoidal Semantic Congruence for Robust AI Text Detection

The rapid proliferation of Large Language Models (LLMs) has created an urgent imperative for reliable, domain-general machine-generated text detection. Existing statistical detectors relying on token-level perplexity or white-box log-likelihoods exhibit pronounced vulnerabilities...

Cumulative Opioid Exposures in the First Year of Life and Cognitive Neurodevelopment in High-Risk Infants

BACKGROUND: High-risk infants with significant neonatal-perinatal morbidities often require opioids, but prolonged exposures can impair neurodevelopment. We evaluated the effect of cumulative opioid exposures in the first year of life, measured by morphine milligrams equivalents...

The Cognitive Switching Hysteresis Certificate: Exact loop geometry under directional state-change penalties

Proof-reconciled generated exploration of a bounded two-state relay model. This public working-corpus release includes the reviewed manuscript and paired Lean evidence. It is not peer reviewed or empirically validated; significance and novelty have not been independently establis...

Hepatic Artery Doppler Haemodynamic Indices as Imaging Biomarkers of Disease Activity in Adults with Chronic Hepatitis B: Correlation with Viral Load and Serum Alanine Transaminase

Abstract Background: Hepatitis B is a common cause of chronic liver disease. Early features of fibrosis are detectable using ultrasound and Doppler imaging. Aims: This study evaluated relationships between hepatic artery Doppler parameters, serum alanine transaminase (ALT) and he...

Fructose directly remodels the translocase of the outer membrane to impair oxidative phosphorylation in podocytes

Excessive dietary fructose consumption contributes to the rapidly increasing prevalence of obesity, metabolic syndrome, and chronic kidney disease worldwide, and accumulating preclinical evidence has confirmed that excess fructose exposure provokes severe mitochondrial dysfunctio...

Piezo1 drives fibroblast activation in epidural fibrotic remodelling via the ET-1/HIF-1α pathway

Aims: Epidural fibrosis is a major cause of failed back surgery syndrome following laminectomy. While previous studies have focused primarily on the early phases of scar formation, fibrotic remodelling remains poorly understood. This study aimed to investigate the interaction bet...

Safety of Day Case Percutaneous Liver Biopsies at a Tertiary Hospital in Nigeria

Abstract Background: Percutaneous liver biopsy (PLB) is a procedure through which liver tissue is obtained for making the diagnosis of liver diseases. Most PLBs are performed as a day case procedure, and complications can occur. Objective: This study assessed the safety of PLBs a...

When the Circuit Isn't There: Establishing Absence in a Behavioral Sequence Model

Conference note: Accepted for poster presentation at the 3rd New England Mechanistic Interpretability (NEMI) Workshop, Boston University, August 14, 2026. See the NEMI Accepted Work page. 10.5281/zenodo.21970594 Motion Sequencing tokenizes mouse behavior into a fixed vocabulary o...

When the Circuit Isn't There: Establishing Absence in a Behavioral Sequence Model

Conference note: Accepted for poster presentation at the 3rd New England Mechanistic Interpretability (NEMI) Workshop, Boston University, August 14, 2026. See the NEMI Accepted Work page. 10.5281/zenodo.21970594 Motion Sequencing tokenizes mouse behavior into a fixed vocabulary o...

Are large language models such as ChatGPT, capable of supporting patients and general practitioners after spine surgery?

Abstract Purpose To evaluate whether large language models (LLMs) can provide accurate, complete, and audience-adapted answers to common spine-surgery–related questions for patients and family practitioners. Methods Ten frequently asked spine-surgery questions were collected at a...

Effects of robotic glove-assisted task-oriented mirror therapy on hand motor function in sub-acute stroke patients: Randomised controlled trial

Background: The incidence of stroke has increased globally, leading to mortality and disability. Approximately 30–66% of stroke survivors are unable to regain motor functions in the affected hand throughout their lives, which significantly impacts their functionality and daily ac...

Temporal Out-of-Sample Predictability of Primes Through Convergences in the Prime-Gap Sequence

This work investigates a deterministic structure derived from the sequence of prime gaps. Consecutive-prime gaps are accumulated to construct a natural representation in which distinct rows may converge to the same value V. These convergences generate advance announcements associ...

Development of a Ce4W9O33 embedded functionalized halloysite nanotube nanocomposite for sensitive electrochemical detection of phenolic aldehyde vanillin in food matrices

A novel Cerium-Tungsten Heteropolyoxometalate intercalated on Halloysite Nanotubes (Ce 4 W 9 O 33 @f-HNT) nanocomposite was successfully synthesized using a hydrothermal method and utilized to construct an efficient electrochemical sensor. The complete structural, morphological,...

The Superfluid Vacuum Substrate (SVS): A Causal Continuum Mechanics Framework for Physical RealIty

The Superfluid Vacuum Substrate (SVS) framework introduces a scale-invariant, causal continuum mechanics model of physical reality. Free space is modeled as an active, incompressible fluid medium governed by classical hydrodynamic properties: permittivity as elastic compliance, p...

Intelligent decision analytics with recursive learning for competitive sports management

The increasing availability of sports performance data has created new opportunities for data-supported decision-making in competitive sports management. However, redundant and strongly correlated performance indicators can increase analytical complexity and distort the influence...

Beyond income: financial hardship as a pathway from socioeconomic disadvantage to depression among middle and older cancer survivors

BACKGROUND: Depression disproportionately affects older cancer survivors with fewer socioeconomic resources, yet the mechanisms underlying this disparity remain under-explored. Guided by Fundamental Cause Theory, this study examined whether financial hardship mediates the relatio...

Comparison of Ultrasound versus Combined Peripheral Nerve Stimulator Plus Ultrasound-guided Supraclavicular Blocks of Brachial Plexus for Upper Limb Surgeries

Abstract Background: Ultrasound (USG)-guided supraclavicular blocks are an asset in the realm of regional anaesthesia. Newer approaches, such as USG plus peripheral nerve stimulator (PNS), have often been indicated for better outcomes. Aim: The aim of the study was to compare USG...

Integrative Analysis of Genome Data Using Deep Embedded Clustering to Identify Population Stratification and Functional Gene Modules

AbstractIntroduction: Next-Generation Sequencing (NGS) data analysis faces computational challenges due to high dimensionality. Traditional clustering methods fail to capture biological complexity in human genetic variation. This study introduces Deep Embedded Clustering (DEC) fo...