Research works

Influence of splinted vs. non-splinted scan bodies on digital impression accuracy in all-on-four implant rehabilitation: a comparison with conventional open-tray impressions

This in vitro study aimed to evaluate and compare the accuracy of conventional and digital implant impression techniques using different intraoral scanners, implant systems, and splinting protocols in full arch implant rehabilitation. Two mandibular epoxy-resin models were fabric...

Cornepalenins A–D, picrotoxane-type sesquiterpenes from the flowers of Coriaria nepalensis associated with modulation of GABAB receptor–related signaling

Three new picrotoxane-type sesquiterpenes (PSTs) cornepalenins A–C ( 1 – 3 ), along with eight known analogues ( 4 – 11 ), were isolated and identified from the flowers of Coriaria nepalensis . In addition, the spectroscopic data and absolute configurations of the known compound...

Mechanical and microstructural properties of Phaselis Roman mortar based on hydraulic lime characterization with calcite and recycled brick and optimization with Taguchi method

This research focuses on the sustainable use of materials by analyzing the chemical and mechanical effects of adding a hydraulic lime-based binder, calcite (CaCO 3 ), and recycled brick powder to Roman mortars from Phaselis. The main objective of the study was to determine the ef...

A Study on Network-Based Storage Acceleration: Taxonomy and Trade-off Analysis

대규모 AI 및 데이터센터 워크로드의 비중이 급증함에 따라, 컴퓨팅 노드와 스토리지 노드를 분리하여 자원 효율성을 극대화하는 분리형 스토리지 기술이 필수적으로 요구되고 있다. 그중 NVMe/TCP 프로토콜이 가장 각광받고 있으나, 프로토콜 처리로 인한 막대한 호스트 CPU 오버헤드가 시스템 전체의...

HIRA loss is frequent but not universal in human fumarate hydratase-deficient renal cell carcinoma and defines divergent oncogenic programs

Fumarate hydratase-deficient renal cell carcinoma (FH-dRCC) is a rare and highly aggressive malignancy driven by fumarate accumulation and widespread epigenetic reprogramming. Although Valcarcel-Jimenez et al. have demonstrated that loss of the histone chaperone Hira is a critica...

Discriminative Non-negative Matrix Factorization Model with Local Manifold Preservation

Non-negative matrix factorization (NMF) has been widely studied for data representation learning and dimensionality reduction. However, existing NMF-based approaches often suffer from limitations such as inadequate preservation of manifold structure and insufficient exploitation...

Comparative evaluation of the effect of whey protein powder and plant-based protein powder on the microhardness, sorption, and solubility of a nano-hybrid giomer restorative composite: an in vitro study

Whey and plant protein powders are becoming common additions of people concerned with fitness in their diet. Consumed repeatedly as reconstituted shakes, these products remain in contact with the dentition for extended periods and introduce a chemically heterogeneous mixture of o...

Engineering chitosan functionalized extracellular vesicles for targeted brain gene delivery and neurotherapeutics

Gene therapy represents a crucial frontier in modern medicine for brain diseases; however, a significant obstacle hinders its progress. The immense difficulty of therapeutic molecules that deliver to the brain should be in a safe and effective way. The challenge is that blood bra...

Comparative efficacy and safety of oral iron polymaltose complex vs. ferrous sulphate in the treatment of pediatric iron deficiency anemia: a systematic review, meta-analysis and trial sequential analysis

Oral iron supplementation is the first-line therapy for pediatric iron deficiency anemia (IDA). Ferrous sulphate (FS) remains the conventional standard of care but frequently induces gastrointestinal (GI) adverse effects. Iron polymaltose complex (IPC) has emerged as an alternati...

Triglyceride–glucose index as a cardiovascular risk marker: updated evidence, limitations, and future perspectives

Cardiovascular diseases (CVDs) remain the foremost cause of morbidity and mortality worldwide, accounting for a substantial burden on healthcare systems, economies, and society. Traditional risk factors do not fully explain residual cardiovascular risk, highlighting the role of i...

Microbial Shifts in Metisa plana (Lepidoptera: Psychidae) Larvae Exposed to Bacillus thuringiensis and Flubendiamide

Microbial communities in the insect body, especially in the gut, are crucial for host development, health, and environmental adaptation. However, little is currently understood about how these communities react to anthropogenic stressors, particularly when pesticides are used. Th...

Development, validation, and visualization of a CT-based predictive model for pedicle screw loosening risk after posterior lumbar fusion

This study aimed to develop and validate a visualization-based predictive model for evaluating the risk of pedicle screw loosening (PSL) following posterior lumbar interbody fusion (PLIF) in patients with lumbar degenerative conditions. A total of 466 consecutive patients undergo...

Anaesthetist-led perioperative transthoracic echocardiography service: a clinical audit

INTRODUCTION: Growing enthusiasm for transthoracic echocardiography (TTE) among non-cardiac specialties has led to the development of multiple focused TTE protocols in recent years. The role of echocardiography in anaesthesiology is also evolving; an increasing number of anaesthe...

Effects of a high-intensity interval training program on physical and physiological parameters in adolescent female field hockey players

High-intensity interval training (HIIT) is frequently used in the field of sports to promote physical fitness through exercises that include speed, agility, cardiorespiratory capacity, maximum strength, explosive power, and flexibility. In this study, the effect of a HIIT program...

A Simulation-Based Optimization Framework of Stochastic Manufacturing Systems Using External Optimizer

In this paper, we investigate a simulation-based optimization framework that implements discrete-event simulation with evolutionary search methods to optimize stochastic manufacturing systems efficiently. The proposed methodology couples a Tecnomatix Plant Simulation model with a...

Risk prediction model and intervention strategies for intraoperative hypothermia in robotic-assisted urological surgery

To develop a risk prediction model for intraoperative hypothermia in patients undergoing robotic-assisted urological surgery and formulate hierarchical warming strategies. This single-centre retrospective study calculated the sample size using G*Power 3.1. A total of 487 patients...

Award-mediated scripts of advertising measurement: Evidence from MIXX Awards Türkiye success stories

Advertising effectiveness is increasingly evaluated in environments shaped by platform-specific metrics, fragmented data, and privacy-constrained attribution. Organizations still need shared scripts that render performance claims intelligible to clients, juries, and peers. This s...

CRISPR/Cas9 knockout of N-acetyltransferase 1 influences mesenchymal transition in glioblastoma in a cell line dependent manner

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and carries a poor prognosis despite standard of care treatment with surgical debulking, chemotherapy, and radiotherapy. Proneural to mesenchymal transition (PMT) is a key driver of GBM invasion and tre...

Integrating convolutional variational autoencoders and the Gaussian mixture model for efficient manifold learning and clustering of spatially preserved EEG topographic maps

EEG microstate analysis segments continuous brain activity into brief, quasi-stable topographic configurations whose quantity, duration, and transition dynamics index cognitive state and neuropsychiatric conditions. The standard algorithm, modified k -means (ModKMeans), operates...

Association between metabolic score for visceral fat and hypertension in Korean adults: a nationwide population-based study

Background: Hypertension, one of the major risk factors for cardiovascular disease, is associated with visceral adiposity accumulation. Accordingly, we aimed to investigate the association between the metabolic score for visceral fat (METS-VF), a novel surrogate marker of viscera...