Research works

Robust predictive analysis of international mobility among research talents

International organizations, policymakers and researchers have taken notice of the many facets of international mobility and its impact on both the countries of origin and destination. International mobility of research talent has become a critical concern for a developing nation...

Chronic arsenic exposure induces hepatic lipid metabolism disorder by regulating the FXR/SREBP1 signaling pathway

Arsenic is a widespread environmental metalloid contaminant that primarily targets the liver, inducing hepatic injury and metabolic disturbance. However, the precise mechanisms underlying chronic arsenic exposure-induced hepatic lipid dysregulation have not been fully elucidated....

Metric Tensor Folding and Discrete Structural Alignment: Bypassing GEMM via T112 Lattice Geometry and Inversion Transduction Grammars

Abstract:State-of-the-art natural language processing architectures remain constrained by continuous floating-point matrix multiplications (GEMM) and quadratic attention scaling, imposing severe memory bandwidth and thermal taxes on silicon substrates. We present a unified framew...

Comparison of transumbilical single-port and conventional multi-port laparoscopic hepatectomy for benign liver lesions

Transumbilical single-port laparoscopic hepatectomy represents a further refinement of minimally invasive liver surgery, but its safety and perioperative value remain insufficiently defined. This study aimed to compare transumbilical single-port laparoscopic hepatectomy with conv...

Papillary urothelial neoplasm of low malignant potential: real-world diagnostic pitfalls and clinical outcomes from a case series

Papillary urothelial neoplasm of low malignant potential (PUNLMP) is an uncommon non-muscle-invasive bladder tumor. Its indolent nature often leads to underestimation of diagnostic complexity and recurrence risk, particularly in real-world practice where pathological distinction...

Optimal timing of endoscopic retrograde cholangiopancreatography and laparoscopic cholecystectomy in the management of cholecystocholedocholithiasis: a multicenter retrospective analysis

To compare the clinical outcomes of ERCP combined with laparoscopic LC using both one-step and two-step approaches for the treatment of cholecystocholedocholithiasis, and to investigate the optimal timing for performing LC within two weeks after ERCP. The clinical data of 520 pat...

Association of P53 and P16 expression with surgical and oncologic outcomes in vulvar squamous cell carcinoma: a retrospective cohort study

The aim of this research is to evaluate the relationship between p53 and p16 expression and various clinicopathologic features, surgical interventions, and oncologic outcomes in patients diagnosed with vulvar squamous cell carcinoma (VSCC). We carried out a retrospective cohort s...

Hydrogen bond mediated oxidation enables sustained oxygen evolution at industrial current densities

Stable and efficient non−precious electrocatalysts are crucial for the industrialization of anion exchange membrane water electrolysis as a green hydrogen production technology. Here, we show a synergistic dual-anion engineering combining Se doping and surface [B(OH)4]− modificat...

Rhizobia-mediated soybean rhizosphere and nodule endophytic microorganisms reduce bioavailability of Cd and Cu in soil

Low-level bioavailable cadmium (Cd) and copper (Cu) in agricultural soils poses a severe threat to soil health and food safety; however, the mechanisms by which indigenous Cu-Cd tolerant rhizobia modulate plant-microbe-soil interactions remain poorly understood. In this field tri...

Sirtuin 1 Inhibition Attenuates Viral Myocarditis by Suppressing the Nuclear Translocation of Pyruvate Kinase M2 to Rebalance Th17/Th9 Differentiation

Sirtuin 1 (SIRT1) regulates CD4 + T cell differentiation, particularly Th17 and Th9 subsets, in various autoimmune and inflammatory diseases, but its role in viral myocarditis (VMC) remains poorly understood. In this study, using a coxsackievirus B3 (CVB3)-induced VMC mouse model...

Itaconate as a central node in immunometabolism and inflammatory control

Mitochondria serve as central regulators of cellular bioenergetics and inflammatory signaling, integrating metabolic status with immune responses. Disruption of mitochondrial homeostasis, including altered tricarboxylic acid cycle dynamics, redox imbalance, and aberrant reactive...

Synchronized actuation strategy and study of clap-and-fling phenomenon in hummingbird inspired robot

This study presents the design and development of a hummingbird-inspired robot, engineered to mimic the flight dynamics of a real flapping bird through synchronized flapping. While prior flapping-wing robotic studies have primarily focused on mechanical design or open-loop actuat...

Ultrasound-assisted glycyrrhetinic acid/nitric oxide co-loaded albumin nanoparticles for the synergistic treatment of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is widely recognized as one of the three leading causes of cancer-related death worldwide. Glycyrrhetinic acid (GA) exhibits potent anti-HCC activity, but its poor aqueous solubility limits its clinical application. At high concentrations, nitric ox...

Developmental trajectories and associated factors of cardiovascular disease risk among chinese miners: a 5-year prospective cohort study

To examine temporal patterns in cardiovascular disease (CVD) risk among miners, identify distinct latent trajectory classes, and evaluate factors associated with trajectory membership. We analyzed data from a miner health cohort in Huaibei, Anhui Province, China. Of 4,560 miners...

A large-scale multi-center analysis reveals that HNRNPA2B1 variants increase neuroblastoma risk in Chinese children

Neuroblastoma has significant clinical heterogeneity, more precise genetic biomarkers are needed for early risk stratification. Although m 6 A modification has been reported to affect tumor development, the epidemiological impact of HNRNPA2B1 polymorphisms on neuroblastoma suscep...

Decoding leadership behaviour insights from college teachers in Mizoram

Teacher leadership behaviour as the ability to mobilize teachers’ available qualities to positively impact students in their everyday activities, both inside and outside the classroom. Teacher leaders are pivotal in facilitating innovative practices, which are essential for build...

Perspectives of nursing among male pre-nursing students: a Q-methodology study

Nursing continues to face workforce shortages globally, and increasing the participation of men has been identified as one strategy for strengthening workforce capacity. In Saudi Arabia, efforts to expand and sustain the national nursing workforce have highlighted the importance...

A bibliometric analysis and systematic literature review of innovation financing mechanisms for technology startups

Research on innovation financing has become more comprehensive, covering different financing mechanisms. But the body of work is still conceptually fragmented, with studies often focusing on individual financing channels rather than how they relate to each other. In addition, the...

The effect of pulmonary nodule presence on disease severity and course in ANCA-associated vasculitis: a multicenter cohort study

Pulmonary nodules are common in ANCA-associated vasculitis (AAV), but their clinical relevance remains unclear. This study assessed the influence of pulmonary nodules and radiological features on clinical characteristics and outcomes in AAV. In this multicenter retrospective coho...

Effects of mandibular advancement device versus continuous positive airway pressure on cardiac remodeling in obstructive sleep apnea: a randomized CMR substudy

Obstructive sleep apnea (OSA) is associated with adverse cardiac remodeling, including diffuse myocardial fibrosis. Continuous positive airway pressure (CPAP) is the standard treatment for OSA, while mandibular advancement devices (MAD) may represent an alternative. However, thei...