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Pediatric Hospital Medicine Board-Certified and Non–Board-Certified Hospitalists Are Welcome Here

The Consortium of Pediatric Hospital Medicine, representing elected leaders in the field of Pediatric Hospital Medicine (PHM), proudly welcomes and fully supports every pediatric hospitalist, sub-board certified and non–sub-board certified alike, as integral contributors to our c...

Systemic and local oxidative stress biomarkers in periodontitis: an updated systematic review and meta-analysis

To update and extend our previously published 2019 systematic review by evaluating oxidative stress (OS) biomarkers in saliva, gingival crevicular fluid (GCF), and blood in relation to periodontitis. We systematically searched five electronic databases including PubMed, Scopus, E...

Benchmarking Pattern Mining Algorithms for Service Non-Adherence: From Algorithms to Driver Insights

Cancellations and no-shows pose substantial challenges for service industries, yet research has primarily emphasized prediction rather than analysis of the underlying drivers, with most work centred on healthcare. This study presents an empirical comparison of four pattern mining...

Outcome and erosion of root-end filling materials following endodontic apical surgery: a minimum follow-up of 4 years

OBJECTIVES: To evaluate the long-term outcomes of apical surgery using intermediate restorative material (IRM) and hydraulic calcium silicate cements (HCSCs) as root-end filling materials. MATERIALS AND METHODS: Apical surgery was performed between 2012 and 2020. Of the 336 teeth...

Beyond prostate-specific antigen: ctDNA as an early compass for treatment adaptation in metastatic prostate cancer

In a recent study published in Nature Cancer , Jayaram and colleagues 1 demonstrated that persistent circulating tumor DNA detection during first-line intensified therapy independently predicts poor survival in patients with metastatic castration-sensitive prostate cancer, provid...

Environmentally-assisted cracking behaviour of EUROFER97 under simulated water-cooled breeder blanket conditions

Abstract The reduced activation ferritic martensitic (RAF/M) EUROFER97 steel is the candidate structural material for the water-cooled lithium lead breeding blanket (WCLL-BB) section in the DEMO fusion reactor. Its performance under environmentally-assisted cracking (EAC) conditi...

Doravirine/Islatravir (Idvynso) for HIV

The FDA has approved Idvynso (Merck), a once-daily fixed-dose combination of the non-nucleoside reverse transcriptase inhibitor (NNRTI) doravirine and the first-in-class nucleoside reverse transcriptase translocation inhibitor (NRTTI) islatravir, to replace the current antiretrov...

Enlicitide (Lipfendra) – An Oral PCSK9 Inhibitor for LDL-Cholesterol Lowering

Enlicitide (Lipfendra – Merck), an oral proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitor, has been approved by the FDA to reduce low-density lipoprotein cholesterol (LDL-C) in adults with hypercholesterolemia, including heterozygous familial hypercholesterolemia (H...

Olezarsen (Tryngolza) for Severe Hypertriglyceridemia

The FDA has approved olezarsen (Tryngolza – Ionis), a subcutaneously injected apolipoprotein C-III (apoC-III)-directed antisense oligonucleotide, to reduce triglyceride levels and the risk of acute pancreatitis in adults with severe hypertriglyceridemia. Olezarsen and the apoC-II...

In Brief: Rextovy — Another OTC Naloxone Nasal Spray

The FDA has approved the over-the-counter (OTC) sale of Rextovy (Amphastar), a nasal spray formulation of the opioid antagonist naloxone, for emergency treatment of opioid overdose.1 Other naloxone nasal sprays (Narcan, and generics; RiVive) are also available OTC (see Table 1).

Protocol for integrating vessel networks and environmental matching to inform cost-effective archipelago biosecurity planning and management

Inter-island vessel networks support economic activity but also enable secondary spread of non-native species. By integrating vessel-movement data, network analysis, and environmental matching, we present a protocol for generating a cost-effective biosecurity decision-support too...

‘The most advanced outpost of cultivation’: palynological evidence for cereal agriculture and population resilience in a marginal upland environment

ABSTRACT Upland farming in Europe is frequently assumed to have been limited and precarious, despite relict spade‐dug ridges providing firm evidence of past crop growing. Direct evidence for crop types in post‑Medieval to Modern (~since 1500 CE) uplands is rare; yet, in Ireland,...

Numerical Evaluation of the Two-Fluid Hydrodynamic Coefficients and Temperature-Dependent Second Sound in a Finite-Temperature Bose Gas

We present a numerically stable evaluation of the two-fluid hydrodynamic coefficients for a dilute Bose gas of rubidium-87 at finite temperature. Our contribution is threefold: (i) we compute the condensate gradient stiffness $B$, the entropy density $S$, and the specific heat $c...

Analysis of Six Fundamental Mathematical Problems of the Ternary Global Unified Dynamical System《元全域统一动力学体系的六大数学基础问题解析 —— 理论完备性最终证明与工程边界界定》

This is the final‑printing closing manuscript (V29‑final) of the Ternary Steady‑State Theory theoretical system. This definitive release completes the full Chapter 7, including the algebraic global‑asymptotic stability proof via the Hurwitz criterion, the definition of the resili...

Taming the tilt: A unified pilot control concept for transformational eVTOL aircraft

Abstract Transformational electric vertical take-off and landing (eVTOL) vehicles have gained significant attention over the past decade due to their efficient wing-borne cruise capabilities and reduced reliance on ground-based infrastructure. However, control system design for t...

Application of Artificial Intelligence in HPV Related Cervical Cancer Diagnosis: A Systematic Review

Objectives: This review aims to quantify AI diagnostic performance specifically for HPV-related cervical cancer detection, stratified by methodological category, and to evaluate the added value of HPV genotype integration. Methods: A systematic review was conducted following PRIS...

Effective Reproduction number of Conjunctivitis Viral Disease

Objectives: In this study, an SEIR mathematical model of conjunctivitis viral disease is formulated to analyze the effects of the control measures including social distancing and treatment. Method: The basic reproduction number is computed using the next generation matrix method...

A union-bound tolerance rule and the information price of a fitted orientation in spatial-coincidence tests on the sphere

Duplicate deposit — do not cite this record. The same manuscript was deposited twice within two minutes on 24 August 2026 by two parallel automated sessions of the same author. The record of reference is 10.5281/zenodo.22077512; please cite that identifier. The content of the two...

God's Dealings during the Life of Cain: A Juridical-Theological Reopening of the Case in Genesis 4

How should God’s own role in Genesis 4 be understood when one examines the actions the text attributes to Him with the same scrutiny as those of Cain — a question which the narrative itself never poses, because no party within it is in a position to raise it? Centred on this ques...

Hybrid Deep Reinforcement Learning with Kookaburra Optimization for QOS-Aware Bandwidth Allocation in GMPLS Optical Networks

Objectives: To address dynamic bandwidth allocation with strict Quality of Service (QoS) requirements in Generalized Multi-Protocol Label Switching (GMPLS) optical networks under strain from internet services, real-time multimedia, and cloud infrastructure. Method: A Hybrid Deep...