Research works

Mechanical thrombectomy in nonagenarians: real-world outcomes from a highly selected cohort treated at a comprehensive stroke center

Abstract Background Evidence supporting mechanical thrombectomy (MT) in very elderly patients remains limited, as nonagenarians are underrepresented in randomized trials and frequently excluded from MT in routine practice. We evaluated the effectiveness and safety of MT in carefu...

Infrastructure‐Constrained Pathways for Large‐Scale CO 2 Mitigation via CCUS in China's Coal‐Fired Power Sector

ABSTRACT Carbon capture, utilization, and storage (CCUS) is essential for decarbonizing coal‐dominated power systems, yet its large‐scale deployment in China is constrained by high costs, uneven storage resources, and limited transport infrastructure. This study develops a plant‐...

The impact of an intensive care telemedicine program on weaning from invasive ventilation: a secondary analysis of the ERIC trial

Abstract Background ICU patients commonly require invasive mechanical ventilation. Although weaning from ventilation is crucial for patient outcomes, it is commonly not performed according to guideline recommendations. We investigated if a complex telemedicine intervention improv...

Flexible MultimodalNeural Probe with Integrated Three-ElectrodeAptameric Sensing for In Vivo Monitoring of DopamineDynamics and Neural Activity

Abstract Neural function emerges from the interplay between electrical activity and neurochemical signaling, yet most implantable neural interfaces primarily record electrophysiological signals and lack molecular specificity for neurotransmitter monitoring. Here, we developed a f...

The Supply chain Health INitiative Evaluation (SHINE) study protocol: evaluating health and wellbeing services delivered through the supply chain

Abstract Background While three-quarters of Small and Medium Sized Enterprises (SMEs) provide some form of health and safety training to their employees, more comprehensive health and wellbeing services (HWS), including health prevention and occupational health activities are not...

Identification and validation of RNA-binding protein-associated biomarkers in esophageal cancer

Abstract Background Esophageal cancer (ESCA) is highly prevalent globally, but the role of RNA-binding proteins (RBPs) in it remains unclear. Methods ESCA datasets were analyzed to identify differentially expressed genes (DEGs). Candidates were derived by intersecting DEGs with R...

Magnetic resonance imaging-based morphometric differences in the normal pituitary gland with functional and nonfunctional pituitary adenomas

Background: Pituitary adenomas (PAs) are common intracranial neoplasms classified as hormone-secreting or nonfunctional. Nonfunctional PAs (NFPAs) typically present at larger sizes and exert greater mass effect on surrounding structures, including the pituitary gland (PG) and pit...

Cannabis‐Based Oil for Pain and Other Non‐Motor Symptoms in Parkinson's Disease: A Randomized Controlled Trial

BACKGROUND: There is a lack of treatments for non-motor symptoms (NMS) in Parkinson's disease (PD). OBJECTIVE: To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. METHODS: This phase II, randomized, placebo-controlled trial ev...

Bulk and single-cell multiomics insights into theca cell and granulosa cell dysfunction in polyendocrine metabolic ovarian syndrome

Abstract Polyendocrine metabolic ovarian syndrome (PMOS) is a heterogeneous disorder marked by a variety of clinical, hormonal, and metabolic disorders of an endocrine nature, affecting women of reproductive age and causing anovulatory infertility, metabolic dysfunction and hormo...

IntramolecularHeterojunctions for Highly SensitiveRoom-Temperature NO2 Sensing

Abstract Heterojunction materials achieve efficient charge transfer and carrier separation through built-in- electric fields at the interfaces, thereby substantially enhancing the sensitivity and selectivity of gas sensors. However, traditional particle-contact heterojunctions su...

Bundled cross-strata from Martian rocks suggest an Earth-like cyclic self-organisation of bedforms

Cross-strata on Mars are expressions of ancient bedforms formed due to sediment transport by either wind or water. Some of these cross-strata show peculiar features, including intercalated mudstone drapes, discontinuity surfaces and cyclic patterns in stratum thickness (i.e. bund...

Low energy neutron light output characterization of EJ301D and deuterated stilbene with a comparison of light output characterization methods

The neutron-induced light yield of a 2.54 cm diameter by 2.54 cm long right circular cylinder of EJ301D and a (5.08 cm) \(^3\) custom made cube of deuterated trans -stilbene-d \(_{12}\) (d-stilbene) were measured over incident neutron energies from 300 keV to 2.2 MeV and 200 keV...

Late-onset infective endocarditis after transcatheter atrial septal defect device closure involving mechanical factors: a case report

Late-onset infective endocarditis after transcatheter atrial septal defect device closure is uncommon, and in selected patients, mechanical factors related to adverse device-tissue interaction may contribute to the development of late device-related infection. A 15-year-old boy p...

Isolation policies in musculoskeletal infection care: time to move from tradition to evidence

Abstract. A recent scoping review found no evidence supporting routine ward-level isolation or dedicated septic wards for non-multidrug-resistant organism musculoskeletal infections when standard precautions are applied, whereas targeted measures remain appropriate for multidrug-...

Scalable Synthesisof a Masked Thiophenol as an Air-Stable,Odorless Intermediate to the Aurora Kinase Inhibitor Tozasertib (VX-680)

Abstract The use of thiophenols on process scales is fraught with challenges relating to their toxicity, malodor, and air sensitivity. We previously demonstrated that the Ni-catalyzed C–S coupling of aryl iodides and thiourea provides a discovery-scale route to S-aryl isothiouron...

Existence and Finiteness of Equilibrium States for Partially Hyperbolic Endomorphisms

Abstract We establish the existence and finiteness of equilibrium states for a class of partially hyperbolic endomorphisms. In our first result, we assume that the central direction is simple. In the second result, we consider the case where there exists a dominated splitting alo...

Prognostic value of the inflammatory prognostic index for postoperative recurrence in non-muscle-invasive bladder cancer

Abstract Background To evaluate the prognostic value of the inflammatory prognostic index (IPI) for recurrence after transurethral resection of bladder tumour (TURBT) in non-muscle-invasive bladder cancer (NMIBC), and to compare its discriminatory performance with that of the neu...

Thermal analysis in pharmaceutical sciences: a critical narrative review with focus on drug–excipient interactions

Abstract Thermal analysis has become an indispensable component of the modern pharmaceutical preformulation toolbox, providing rapid, low-mass, and information-rich answers to questions of identity, purity, polymorphism, thermal stability, and—most critically—drug–excipient compa...

Time-ResolvedPolymorphism in a Cd-MOF with Dual Applicationsin Iodine Adsorption and One-Pot Tandem Knoevenagel–MichaelCyclocondensation Catalysis

Abstract Metal–organic frameworks (MOFs) are highly advanced porous materials with tunable structures, high surface areas, and multifunctional properties, making them attractive for applications in environmental remediation, gas storage, sensing, and catalysis. In this work, two...

The Mathematics Commons: a Leiden-led peer-to-peer review pilot

The Mathematics Commons is a public discussion draft for a decentralized, AI-integrated mathematics workflow. Its immediate proof of concept is a small GitHub-native pilot for bounded literature review, exact statement work, proof and counterexample search, computation, expositio...