Research works

Prioritizing clinical utility to use allostatic load as a biomarker of the consequences of stress

Allostatic load measures the physiological consequences of stress and is associated with disease outcomes. Clinical use of allostatic load is limited, in part, because its calculation requires biomarkers not routinely measured in clinical care. Presently, we evaluated association...

USP2 is associated with mitochondrial respiratory activity and cell viability in endometrial stromal cells in endometriosis

Mitochondrial dysfunction has been implicated in the pathophysiology of endometriosis, but the role of ubiquitin-specific protease 2 (USP2) remains unclear. This study aimed to determine whether USP2 modulates mitochondrial respiratory activity and proliferation in ectopic endome...

Clinical and Economic Burden of Complicated Pneumonia and Invasive Disease due to Streptococcus pneumoniae Serotype 19A in an Ecuadorian Pediatric Reference Hospital

Serotype 19A has emerged as an important cause of pneumococcal disease following the introduction of the 10-valent pneumococcal conjugate vaccine (PCV10). In this retrospective study of children hospitalized with culture-confirmed invasive pneumococcal disease at an Ecuadorian pe...

Potassium-Ion Conducting Amorphous-Based Chlorides KTaCl6 Prepared via Mechanochemistry

Abstract All-solid-state potassium batteries have attracted considerable attention as energy storage devices. The development of suitable ionic conductors has received significant attention for the commercialization of the batteries. Here, we report the potassium-ion conductors K...

The importance of spatial structure in biology

Abstract Living things are highly complex and organised. This is often taken as an objection to reductionism and a point in favour of organicist views, which argue for the central role of the organism in all biological explanations. This paper argues that biological organisation...

Admission cardiac and renal biomarkers for early identification of type 1 cardiorenal syndrome after acute myocardial infarction

This retrospective study evaluated the diagnostic screening and early identification value of admission baseline cardiac and renal biomarkers for newly developed in-hospital type 1 cardiorenal syndrome (CRS) after acute myocardial infarction (AMI). Baseline samples were collected...

Directional Probe Energy in Banded Fractional Hessians Fractional stiffness, angular completeness, spectral mixing, and the geometric-coercivity problem

We introduce a banded fractional-Hessian framework for measuring the scale-dependent energy of tube-localized directional probes. For an -normalized probe concentrated in a unit-length tube of transverse radius , a band with fractional stiffness index contributes energy of order...

Silicon-Based Highly c -Axis-OrientedStrontium Barium Niobate Films with Large Pockels Coefficients

Abstract To develop a new generation of high-performance silicon-based electro-optic modulators, it is necessary to find an electro-optic crystal with a simple fabrication process, stable chemical properties, and large Pockels coefficients, such as strontium barium niobate (SrxBa...

Cargo Drones and Road Vehicles for Lightweight, Time‐Sensitive Mid‐Mile Shipments: An Integrated Cost, Reliability, and Operational Emissions Analysis

ABSTRACT Lightweight, time‐sensitive shipments represent a narrow mid‐mile logistics segment in which cargo drones may complement, rather than replace, road freight. This study develops a scenario‐based analytical framework to compare cargo‐drone, dedicated‐road, consolidated‐roa...

Skeletal malocclusion and surgical-level skeletal discrepancies: a retrospective cephalometric study using Steiner and McNamara analyses

To assess skeletal malocclusion patterns and surgical-level skeletal discrepancies using Steiner and McNamara cephalometric analyses. This retrospective cross-sectional radiographic study was conducted at the Faculty of Dentistry, Sana’a University, and included 353 randomly sele...

Effect ofFracture Aperture and Water Saturation onthe In Situ Conversion of Tar-Rich Coal

Abstract With abundant coal resources globally, in situ conversion technology, an emerging unconventional energy development method, is a crucial pathway for achieving efficient and clean utilization of tar-rich coal. However, its application is challenged by the heterogeneity of...

Black Box and Beyond: Auditing Large Language Models, AI Agents, and AI Infrastructure Under the UK and EU Regulatory Frameworks

Regulators in the European Union and the United Kingdom now require organisations to make high risk AI systems auditable, and neither has said what an audit record must be. This paper supplies the missing content. It argues first that a record is evidence only where its modificat...

First mitogenome-based phylogenetic analysis and divergence time estimation of deep-sea elasipodid sea cucumbers (Holothuroidea: Elasipodida)

Elasipodida is a major deep-sea holothuroid order, and distributed across depths ranging from 350 m to 7,000 m. Its high species diversity and extensive bathymetric range make it a key model system for investigating the evolutionary processes and adaptive radiation of deep-sea fa...

Are Signal Peptides Hidden Regulators of Neurodegenerative Disease?

Canonical signal peptides (SPs) are short N-terminal sequences that direct nascent proteins into the secretory pathway, but their role extends far beyond protein targeting. Advances in sequencing and computational tools have enabled their systematic identification across proteome...

Baryon transition current structure (N(1440) Roper radial excitation) revisited: Insights from Patterson function analysis

This work applies Patterson function analysis to reconstruct the spatial distribution of the N(1440) Roper radial excitation transition current using empirical form factors. By dispensing with theoretical modeling, the method yields a density profile that is sharply localized and...

S-AI-CCC: Controlled Cognitive Canonicalization

Background. Large language models routinely transform mathematical expressions, logical formulas, symbolic problems, and unstructured inputs into more regular, compressed, or conventionally normalized forms. We call this phenomenon implicit canonicalization: an emergent statistic...

Radiomics for risk stratification in brain metastases: potential in melanoma brain metastases

The identification of quantitative non-invasive imaging biomarkers, including radiomics, may complement molecular characterization and thereby improve clinical management of neuro-oncological patients. We aimed to identify imaging predictors with improved performance over clinica...

Cataloguing & Referencing Art

In this document, we are creating a collection of objects, such as Internet Hyperlinks, Images, Quotes, etc. This activity is coherent with Mathematics Axiomatic Rules: At the beginning, there was an empty set, and the collection of objects create non-empty sets.

Stochastic Scenario Modelling of Tobacco Taxation in Nepal: Evaluating 5–10 Year Pathways to Achieve a 75 Percent Tax Share

Tobacco consumption is a major public health and economic burden in Nepal, and taxation is a central policy tool for its reduction while increasing fiscal revenue. However, the most effective pathway to achieve the WHO-recommended 75 percent tax share under different reform timel...

A controlled trial of a co-designed virtual reality experience to support wellbeing in students

Abstract Increasing rates of mental health problems among university students require innovative interventions. This study evaluated a multi-sensory, virtual reality (VR) intervention aimed at reducing stress and exam anxiety among students at a healthcare university in the UK. P...