Health & Medicinearticle2026-09-02

Dystonia 3×3: A Training Guideline for Beginners in Botulinum Neurotoxin Treatment of Cervical Dystonia

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Abstract

Cervical dystonia (CD) is a hyperkinetic movement disorder characterized by involuntary muscle contractions leading to abnormal postures of the head and neck. The injection of botulinum neurotoxin type A (BoNT-A) into the muscles involved is the treatment of choice for CD. BoNT-A therapy of CD requires appropriate training, which has not been standardized in Germany. To address the key challenges in BoNT-A education, an expert panel developed a simplified step-by-step treatment guideline for beginners, adapted from the established Col-Cap-Concept (“Dystonia 3×3”). Based on expert consensus, recommendations were developed for the core clinical elements of BoNT-A treatment in CD—recognition of the movement pattern, identification of target muscles, development of an injection plan, ultrasound-guided injection, and dosing, taking into account the target audience of the guideline. As such, Dystonia 3×3 provides a user-friendly beginner’s guidebook, enhancing accessibility and standardization of CD treatment training. Further research is required to evaluate its clinical efficacy and suitability for training.

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Authors: Sebastian Paus, Andreas Funke, Jürgen Hamacher, Bernhard Haslinger, Jan Heckelmann, Chi Wang Ip, Wolfgang H. Jost, Anatol Kivi, Stephan Klebe, John‐Ih Lee, Ebba Lohmann, Frederic Mack, Axel Schramm, Andrea Stenner, Paweł Tacik, Uwe Walter, David Weise

Institutions: Düsseldorf University Hospital, Heinrich Heine University Düsseldorf, Leipzig University, University of Tübingen, Universitätsklinikum Würzburg, Universitätsklinikum Aachen, RWTH Aachen University, Saarland University, Technical University of Munich, German Center for Neurodegenerative Diseases, University of Rostock, University Hospital Bonn, Vivantes Klinikum, Hertie Institute for Clinical Brain Research, Praxis, Westsächsische Hochschule Zwickau, Atos Medical, Fachhochschule für Finanzen Brandenburg, Parkinson-Klinik Ortenau, Knappschaftskrankenhaus Recklinghausen, Federal Highway and Transport Research Institute, Institut Supérieur d’Electronique et des Réseaux & Télécommunications, Asklepios Fachklinikum Brandenburg