Düsseldorf University Hospital

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...

The Influence of Deep Hypothermic Circulatory Arrest on the Incidence of Postoperative Acute Kidney Injury After Pulmonary Endarterectomy

Background: Pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) is performed using phases of deep hypothermic circulatory arrest (DHCA). DHCA has been discussed as a risk factor for cardiac surgery-associated acute kidney injury (...

Diagnostic accuracy of 18F-PSMA-1007 PET/CT and bone scintigraphy for detecting bone metastases in prostate cancer

Abstract Objective The performance of 18 F-labeled prostate-specific membrane antigen ( 18 F-PSMA-1007) positron emission tomography/computed tomography (PET/CT) and bone scintigraphy (BS) for detecting bone metastases in prostate cancer patients was compared. Materials and metho...

Junctional plakoglobin regulates intestinal epithelial cell proliferation via MAPK/ERK signaling

Junctional plakoglobin (JUP) is a desmosomal protein essential for epithelial tissue integrity and epithelial-immune cell crosstalk. Although JUP has been implicated in inflammatory processes, its role in intestinal epithelial repair remains unclear. In vitro, loss of JUP in Caco...

Gut microbiome features in methamphetamine use disorder: external validation of a candidate marker panel and exploratory multi-omics associations

Abstract Methamphetamine use disorder (MUD) is a chronic, relapsing disorder with symptoms most pronounced during withdrawal, yet objective biomarkers remain lacking. Although gut microbial alterations have been reported in substance use disorders, their potential as candidate ma...

Development of a prediction model for occupational satisfaction among cancer patients following counseling in German psychosocial cancer counseling centers

Abstract A prognostic model was developed and internally validated to predict satisfaction with the occupational situation among cancer patients receiving psychosocial counseling regarding return to work (RTW). Data were collected from outpatient cancer counseling centers in Germ...

From Breath‐Hold to Free‐Breathing: Possibilities in High‐Resolution Quantitative Susceptibility Mapping ( QSM ) of the Kidney With Respiratory Gating

PURPOSE: This study aimed to assess the feasibility of QSM in the human kidney during free-breathing using respiratory gating for motion compensation. METHODS: Renal imaging of 15 healthy volunteers was performed using an axial multi-echo GRE sequence on a 3 T MRI scanner. Each s...

Subtonsillar Approach to a Polylobulated Posterior Inferior Cerebellar Artery Aneurysm: A Case Illustration.

BACKGROUND AND IMPORTANCE: Dysplastic and polylobulated aneurysms of the posterior inferior cerebellar artery (PICA) present significant technical challenges because of their irregular geometry and proximity to the lower cranial nerves and brainstem perforators. When endovascular...

Geriatric co-managed prehabilitation before esophagectomy in patients aged ≥ 65 years with esophageal cancer: a prospective feasibility study with matched historical controls

Abstract Purpose Older patients undergoing esophagectomy remain at high risk for perioperative morbidity. This study evaluated the feasibility, safety and adherence of a multimodal prehabilitation program integrated with geriatric co-management in patients aged ≥ 65 years schedul...

Insulin Resistance in the 21st Century: New Takes on an Old Problem—2025 Diabetes , Diabetes Care , and Diabetologia Expert Forum

Insulin resistance is a hallmark of type 2 diabetes and several other metabolic diseases. However, efforts to improve insulin resistance are hindered by the biological complexity inherent to insulin action, as well as conceptual and methodological limitations to date. In Septembe...

Insulin resistance in the 21st century: new takes on an old problem—2025 Diabetes, Diabetes Care, and Diabetologia Expert Forum

Insulin resistance is a hallmark of type 2 diabetes and several other metabolic diseases. However, efforts to improve insulin resistance are hindered by the biological complexity inherent to insulin action, as well as conceptual and methodological limitations to date. In Septembe...

Development of a monoclonal antibody targeting the calcification blocking factor CBF

Chronic kidney disease (CKD) patients suffer from a multitude of comorbidities, with vascular calcification being a major one. Recently, a new 19 amino acid long peptide, called calcification blocking factor (CBF), inhibiting vascular calcification has been identified. CBF concen...

Comparison Between Skeletally‐Anchored and Conventional Maxillary Protraction in Growing Class ΙΙΙ Patients: A Systematic Review and Meta‐Analysis

ABSTRACT Objective The aim of this systematic review was to evaluate the skeletal and dental effects of skeletally‐anchored (SA) maxillary protraction compared with conventional facemask (FM) therapy in growing patients with Class III malocclusion, while controlling for the confo...

Rheumatologists’ expectations and perceptions of T-cell redirecting therapies: results from a cross-sectional survey

Abstract T-cell redirecting therapies (TCRTs), including Chimeric antigen receptor (CAR)-T cells and T-cell engagers (TCEs), are emerging as transformative treatments for autoimmune diseases. However, clinical application is currently restricted to specialized centers, leaving mo...

Bilateral theta burst stimulation as an add-on to schema therapy in major depression: methods and design of a randomized, sham-controlled study

Abstract Schema therapy (ST) is an integrative psychotherapeutic treatment that may be as effective as cognitive behavioural therapy in treating depression. Novel approaches are focusing on augmenting psychiatric treatments with brain stimulation techniques, like repetitive trans...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Exploring work stressors and resources and their perceived effects on symptoms and work ability in employees with multiple sclerosis: a qualitative study

Abstract Background Adverse working conditions can lead to reduced working hours, career changes, or early exit from the workforce among employees with multiple sclerosis. The aim of the present study was to explore work-related stressors and resources, as well as their effects o...

Interferon-γ-response to mycobacterial glycopeptidolipids in patients with pulmonary non-tuberculous mycobacterial infection

Abstract The understanding of host responses to pulmonary infection with non-tuberculous mycobacteria (NTM) is incomplete and immunodiagnostic tools are not established. Unlike mycobacteria of the Mycobacterium tuberculosis complex, several NTM express glycopeptidolipids (GPLs) i...

Parental needs and experiences with e-Health applications in chronic pediatric care – a scoping review

Abstract Background The number of children and adolescents living with a chronic condition is steadily increasing. These conditions often place a considerable burden on affected individuals and their families. E-Health applications have the potential to support families by provid...

Changes in perceived psychosocial working conditions after psychotherapeutic consultation at work – exploratory post-hoc analyses from a randomized controlled trial

Abstract Background Psychotherapeutic consultation at work (PT-A) is a low-threshold intervention providing early work-focused treatment to employees with symptoms of common mental disorders (CMD). This post-hoc analysis explores whether PT-A, compared with routine care, is assoc...