Düsseldorf University Hospital

P1.005. Preliminary Pilot Study Cohort Results - Cost-Effective Surveillance Strategies and Prediction of Cancer Recurrence After Endoscopic Therapy for Barrett’s Esophagus (Endeavor)

Abstract Topic Esophageal Cancer: Barrett‘s Esophagus: High-Grade Dysplasia and Early Invasive Cancer Background In many European countries, esophageal adenocarcinoma (EAC) incidence is increasing [1]. Barrett’s esophagus(BE), strongly associated with EAC, can progress via dyspla...

Investigating the role of serum IL-6 in predicting outcomes of b-cell depleting therapy in multiple sclerosis: a retrospective cohort study

Abstract Background Interleukin-6 (IL-6) plays a pivotal role in autoimmune inflammation through its effects on B-cell differentiation, Th17 expansion, and regulatory T-cell suppression. Given ocrelizumab’s (OCR) mechanism of selective CD20 + B-cell depletion, baseline IL-6 level...

The liver in diabetes: current state and future perspectives

Abstract Diabetes mellitus is strongly associated with metabolic dysfunction-associated steatotic liver disease (MASLD). For many years, MASLD has not been recognised as either a common pathophysiological feature of type 2 diabetes or a diabetes-related complication. This special...

Can parent–child interactions help reduce socioeconomic differences in language development? Results of a German birth cohort study

Abstract Aim Children from socioeconomically disadvantaged families often have lower developmental outcomes than their socioeconomically more advantaged peers. In early childhood, language development (LD) in particular is a key competence for further socialization. There is a ne...

Cardiac Opioid System and Its Role in Heart Failure and Ischemia–Reperfusion Injury

Opioid receptors and peptides act as modulators of cardiac and vascular function. These effects are mediated not only by central mechanisms but also via a local cardiac opioid system, which has gained increasing attention for its potential role in cardiovascular disease and perio...

Influence of dextran deswelling on graft preparation and clinical outcomes in DMEK

Abstract To evaluate the influence of dextran-containing versus dextran-free organ culture media on graft preparation characteristics and postoperative outcomes following Descemet Membrane Endothelial Keratoplasty (DMEK). In this single-center retrospective comparative study, 31...

Caregiver-reported experience of integrated care for children with special health care needs and its sociodemographic, health- and network-related correlates in Germany: Cross-sectional results from the PART-CHILD cohort

Abstract Background Children with special health care needs (CSHCN) often rely on cross-sectoral care networks involving medical, therapeutic, educational, and social services. However, key dimensions of integrated care, including cross-sectoral communication and attention to fam...

Effects of remote ischemic preconditioning on intestinal oxygenation, microcirculation, and mitochondrial respiration within the second window of organ protection in a rodent hemorrhagic shock model

Abstract Background In the setting of high-risk surgery, preventive strategies to maintain intestinal tissue integrity are of particular importance, as no bridging organ replacement therapy exists. Remote ischemic preconditioning (RIPC) has been reported to attenuate organ injury...

[ 18 F ] PSMA ‐1007 PET –Based Recurrence Site Distribution and Predictors of Metastatic Disease in Patients With Biochemical Recurrence of Prostate Cancer

ABSTRACT Objectives Prostate‐specific membrane antigen positron emission tomography (PSMA‐PET) is a sensitive imaging modality for detecting recurrent prostate cancer following definitive local therapy. However, evidence on 18 F‐labeled PSMA tracers in Japanese patients with bioc...

Uncovering the scale and link of two SARS-CoV-2 outbreaks in nursing homes by combining integrated genomic surveillance, contact tracing, and point-of-care testing

Abstract Aim The local public health authority (LPHA) in Duesseldorf received notification of two SARS-CoV-2 outbreaks in nursing home A and nursing home B in October 2021 and embarked on an outbreak investitation to identify the source of the outbreak and epidemiological links b...

Nutrient stress activates RAB5B-mediated autophagy to remodel the synaptic proteome

Abstract Synaptic proteostasis is crucial for maintaining neuronal function and plasticity, yet how synapses adapt to metabolic stress remains poorly understood. Here, we show that nutrient deprivation, particularly serum withdrawal, induces robust autophagy-dependent remodeling...

Boiled or not boiled? – D-aspartic acid in bone proteins as proof of a burial “more teutonico”?

Around the 12th/thirteenth century, a burial method called "more teutonico" was used for the remains of high-ranking individuals who had died far from their homeland and had to be brought back for burial. Before transportation, the bodies or body parts were boiled (macerated) to...