University of Tübingen

High‐Density Magnetomyography With Optical Magnetometers Reveals Spatiotemporal Patterns of Evoked Muscle Activity

ABSTRACT Magnetomyography (MMG) holds great potential as a contactless alternative to electromyography (EMG). However, the spatiotemporal dynamics of the myomagnetic field in vivo remain largely unknown, limiting signal interpretability and hence the use of MMG. Here, the myomagn...

Community composition drives metabolic competition and Staphylococcus aureus colonization resistance in synthetic nasal communities

Abstract The human nasal microbiome is a low-diversity ecosystem whose assembly principles and mechanisms of colonization resistance remain poorly understood. Staphylococcus aureus is a member of the nasal microbiome of some individuals with variable abundance. We hypothesized th...

Switch costs reveal vocal-specific executive demands during flexible action selection in crows

Crows and other corvids exhibit remarkable cognitive flexibility, exercising volitional control that allows them to select, initiate and withhold actions based on deliberate decisions rather than reflex. Among these behaviours, vocalizations are especially demanding, yet crows pe...

Sleep forms flexible context representations in toddlers

Abstract Sleep consolidates episodic memory through a hippocampus-dependent process in adults. Whether and how sleep supports memory consolidation during early life, when hippocampal function is immature, remains unclear. Here, we examined effects of sleep on the consolidation of...

Microbial Degradation of Lignin Generates Iron-Binding Organic Ligands

Abstract The association of organic carbon (OC) with iron (Fe) minerals is a primary mechanism governing soil OC persistence, yet the molecular agents mediating Fe–OC binding remain poorly defined. In this study, we demonstrated that microbial degradation of lignin, one of the ma...

Disease Duration Differentiates Freezing of Gait Response to Subthalamic and Nigral Stimulation for Parkinson's Disease in an Exploratory Multicenter Controlled Trial

BACKGROUND: Freezing of gait (FoG) belongs to most pressing unmet symptoms in the treatment of Parkinson's disease. OBJECTIVES: To explore whether combined subthalamic and nigral (STN + SNr) deep brain stimulation improves FoG compared with optimized STN stimulation alone; to ide...

Diagnostic interpretation of CFH expression in pan-cancer analyses: the importance of factor H–like 1 isoform resolution

Recent pan-cancer analyses have identified Complement Factor H (CFH) expression as an immune-related and prognostic biomarker. However, interpretation of CFH transcriptional data requires consideration of isoform specificity. The CFH gene encodes both full-length factor H (FH) an...

The effects of ICAP learning activities on learning outcomes

Background The Interactive-Constructive-Active-Passive (ICAP) framework makes assumptions about the relationships between observable types of learning activities (passive, active, constructive, interactive), cognitive processes, and learning outcomes. Yet, rigorous empirical stud...

A phosphoinositide and RAB switch controls early macropinocytosis

Macropinocytosis is a non-selective endocytic process by which cells take up large amounts of extracellular fluid into giant vesicles known as macropinosomes. This mechanism is used by immune cells to sample the surroundings for antigens and can be exploited by cancer cells for n...

Land use intensification results in abrupt transitions between extensively and intensively managed grasslands

Abstract Understanding whether land use intensification causes regime shifts (i.e. persistent, large changes in ecosystem states) is of key importance for management, particularly if these shifts occur abruptly as thresholds in land use intensity are crossed. Further, these thres...

The human gut microbiome primes fever after vaccination

Fever is a common adverse reaction to vaccination, contributing to vaccine hesitancy and reduced uptake. To understand variation in fever risk, we longitudinally profiled fecal microbiota, oral temperature, and serological markers in 171 healthy adults receiving Severe acute resp...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Outcomes of front-line tagraxofusp in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) in a real-world scenario

Abstract Tagraxofusp (TAG), a CD123-directed protein-drug conjugate, is approved in front-line and relapsed/refractory blastic plasmacytoid dendritic cell neoplasm (BPDCN). Multicenter real-world outcomes and the contribution of up-front consolidation post-TAG remain less defined...

Critical Membrane Concentration and Baseline Toxicity of Organic Pollutants in a High-Throughput Rainbow Trout Cell Assay

Abstract A high-throughput RTgill-W1 cytotoxicity assay (RTgillHT) was developed using 384-well plates and live/dead staining combined with high-content imaging to quantify cytotoxicity. RTgillHT facilitated a significant increase in sample throughput compared to the OECD Test Gu...

The Other Side of the Eco-Island: Exploring the Heuristic Potential of Inverse Cartography

Abstract Maps not only make spaces visible but also contribute to making certain spatial orders appear desirable, legitimate, or sustainable. This paper builds upon recent work on neopragmatic cartography as well as upon the concept of the inverse landscape and discusses the pote...

Adiponectin-enriched liver-derived ECM attenuates fibrogenic features of activated hepatic stellate cells in a multicellular 3D model

Abstract Background Adiponectin (ADPN), an adipocytokine expressed in multiple tissues including the liver by quiescent hepatic stellate cells (HSCs) has recognized antifibrotic properties. However, most studies rely on simplified 2D systems that fail to capture the liver microen...

In Pursuit of Enduring Inactivation: A Perspective on the Development and Study of Irreversible-Covalent Inhibitors

Abstract Molecules that form irreversible covalent bonds with their targets are a mainstay of drug discovery and chemical biology research. Their ability to permanently inactivate an enzyme target provides a mechanism with significant potential to modulate disease phenotypes. Thi...

Scaling of Island Densities in Multilayer Growth and an Application to α-Sexithiophene Films

Abstract Kinetic Monte Carlo simulations of thin-film deposition are performed with film–substrate interactions slightly stronger than film–film interactions and with layer-dependent Ehrlich–Schwoebel (ES) barriers for molecules to cross step edges. Simulations with rapid changes...

Feasibility, acceptability, and preliminary estimates of a multimodal AKTIVER Heart Delirium Prevention Program in patients indicated for cardiac surgery: study protocol of a randomized controlled PREVENT POstoperative Delirium (PREVENT-POD) Pilot Study

Abstract Background Postoperative delirium (POD) is a common complication in geriatric patients undergoing cardiac surgery. POD is associated with prolonged length of stay in the intensive care unit and hospital, increased mortality, institutionalization, distress, risk of cognit...

Predicting nonunion – a hybrid machine-learning model combining patient factors and mechanobiological simulation features exceeds clinician accuracy

Aims To compare the accuracy of a mechanobiological simulation against that of clinicians in forecasting long bone nonunions, and to determine whether the simulation’s results can be effectively used as input for a machine-learning algorithm. Methods This was a retrospective diag...