Saarland University

Clinical characteristics, treatment patterns, and survival outcomes in ductal prostate cancer: a multicenter retrospective analysis

Abstract Purpose Prostatic ductal adenocarcinoma (PDA) is a rare, aggressive prostate cancer subtype associated with advanced disease and poorer prognosis than acinar adenocarcinoma. Small ductal components influence management and preclude active surveillance. This study analyze...

Tracheal tuft cell-released leukotrienes promote antibacterial immune responses

SUMMARY Tuft cells act as crucial sentinels in the airways that detect bacterial metabolites. In response, tuft cells release signaling molecules that trigger immune responses essential for clearing the infection. The molecular mechanisms driving immune cell activation following...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

Inverse-Problem Approach for 3MA Electromagnetic NDT on Laser-Hardened Materials

This work presents a numerical framework for the electromagnetic modeling and inverse characterization of laser-hardened steels using 3MA (Micromagnetic Multiparameter Microstructure and Stress Analysis) non-destructive testing. The proposed methodology combines a simplified two-...

Variation in glabrous skin physiology across anatomical locations on the human hand

Abstract Skin physiology varies greatly between anatomical locations, with impact on tactile sensitivity. Research on the variations in morphology and physiology between different anatomical locations of glabrous skin is limited so far. This study investigates the morphology and...

Rapid screening of urinary tract infections: quantitative flow cytometry versus dipstick testing in a hospital cohort

PURPOSE: We compared urine dipstick testing (DS) with quantitative flow cytometry (FC) and evaluated a diagnostic algorithm to optimise urinary tract infection (UTI) screening. METHODS: In this single-centre study, 5,124 consecutive urine samples were analysed in parallel using D...

Breakloose Suppression in Minimal Friction Models

Abstract Breakloose friction—the transient friction force peak at the onset of sliding—is often pronounced in nanoscale contacts but weak or absent in macroscopic systems. This behavior is commonly associated with rupture fronts and process-zone effects. However, the mechanisms b...

Ruling In and Ruling Out Sepsis Using Likelihood Ratios of a Host Response Assay

Overview: SeptiCyte RAPID is an FDA-cleared gene expression test that quantifies host immune response to aid in the diagnosis of sepsis. The test yields a score (the SeptiScore) ranging from 0–15, distributed across four bands (1–4) based on increased likelihood of sepsis. Each b...

Understanding the Individual-Level Consequences of Strikes: A Systematic Review and Future Research Directions

Strikes are a recurring workplace phenomenon that affects strikers, their families, and managers, but also others such as commuters. To date, studies examining individual-level effects of strikes have been scattered across different fields of study. This systematic literature rev...