Institution
Universitätsklinikum Würzburg
Recent research
- Health & MedicineOpen access
Lung protective ventilation is crucial for preventing ventilator-induced lung injury in cardiac surgery. The protective role of a low tidal volume (V T ) has been established, whereas the added protection afforded by lung recruitment remains uncertain. We investigated whether sig...
- Health & Medicine
Selective Cell Death of Adrenocortical Cells by Pharmacological Activation of Mutant KCNJ5
BACKGROUND: Primary aldosteronism is frequently caused by mutations in the KCNJ5 (potassium inwardly rectifying channel subfamily J member 5) gene, encoding a G-protein inwardly rectifying potassium channel. These mutations disrupt the channel’s selectivity filter, permitting abn...
- Health & MedicineOpen access
Anxiety and mood disorders from childhood to adulthood in very preterm and term-born individuals
BACKGROUND: Very preterm (VP) birth has been associated with higher rates of anxiety and mood disorders, but the emergence and persistence from childhood to adulthood is unknown. This study examined prevalence rates and early risk factors of these disorders in VP and term-born in...
- Society & EconomicsOpen access
<title>Abstract</title> Major Depressive Disorder (MDD) is a common and costly mental health condition that is often associated with deficits in executive function. Smartphone applications (“apps”) have emerged as promising methods for assessing mental health-related outcomes in...
- Health & MedicineOpen access
BACKGROUND: Patient selection for rechallenge peptide receptor radionuclide therapy (re-PRRT) in neuroendocrine tumors (NET) remains poorly defined. As re-PRRT is increasingly considered in clinical practice, identifying patients most likely to benefit has become a critical yet u...
- Health & MedicineOpen access
Acute kidney injury (AKI) affects up to 50% of critically ill patients and is frequently complicated by severe metabolic derangements, requiring the initiation of replacement therapy (RRT) in 10–15% of cases. Despite substantial progress in the diagnosis of AKI and optimisation o...
- Health & MedicineOpen access
Influence of dextran deswelling on graft preparation and clinical outcomes in DMEK
Abstract To evaluate the influence of dextran-containing versus dextran-free organ culture media on graft preparation characteristics and postoperative outcomes following Descemet Membrane Endothelial Keratoplasty (DMEK). In this single-center retrospective comparative study, 31...
- Engineering & TechnologyOpen access
OBJECTIVE: Myocardial scar assessment is clinically relevant in advanced coronary artery disease, but late iodine enhancement (LIE) CT remains limited by image contrast and validation requirements. This study aimed to evaluate quantitative image quality and reader confidence of p...
- Health & MedicineOpen access
BACKGROUND: Outcomes with sirolimus-coated drug-eluting balloons (DEB) have been positive for the treatment of femoropopliteal arterial lesions but have not been studied in a broader patient population. OBJECTIVES: Collect real-world safety and effectiveness data on the SELUTION...
- Health & MedicineOpen access
Abstract In psychiatry, therapeutic drug monitoring (TDM) is routinely used to improve treatment safety and efficacy, yet its association with hospitalization duration and cost-effectiveness remains unclear. We hypothesized that the frequency of routinely requested TDM is associa...
- BiologyOpen access
Common thought patterns reflect generosity, fairness, and social context
Abstract Humans generate thousands of thoughts each day, many of which concern other people. Yet it remains unclear whether these ongoing thoughts vary systematically across social contexts that demand meaningful social behavior, and whether they reflect individual differences in...