University Hospital Bonn

Autofluorescence Imaging During Surgery for Orthopedic Infection: A Prospective Feasibility Case Series

Background/Objectives: Intraoperative assessment of infected and nonviable tissue remains challenging in orthopedic surgery. This prospective case series evaluated the technical feasibility of VELscope® autofluorescence imaging during surgery for orthopedic infection. Methods: Th...

Virtual reality (bio-)markers differentiate ADHD from depression and controls

The heterogeneity of attention-deficit/hyperactivity disorder (ADHD) and its symptom overlap with other mental disorders limit the clinical utility of isolated diagnostic markers. Virtual reality (VR)-based paradigms offer potential to aid individual diagnostic decisions. This st...

Microsurgical Lymphovenous Anastomosis for the Treatment of Central Lymphatic Flow Disorders in Children and Adults

Central lymphatic flow disorders remain a significant diagnostic and therapeutic challenge. Treatment typically follows a stepwise escalation approach, with reconstructive surgery being employed mainly in patients in whom conservative and interventional methods have failed or are...

Anesthesiological considerations and complications in robotic surgery: a retrospective analysis

Robotic-assisted surgery has become increasingly prevalent across various surgical disciplines. Understanding anesthesiological factors influencing perioperative outcome is essential for optimizing patient care. This retrospective analysis evaluated 200 patients who underwent rob...

Accelerated forgetting in memory clinic patients with subjective cognitive decline: Results from a 7-day follow-up long-term retrieval assessment

BackgroundSubjective cognitive decline (SCD) is recognized as an early indicator of preclinical Alzheimer's disease (AD). However, individuals with SCD do not exhibit cognitive impairment on standard neuropsychological tests. Accelerated forgetting (AF) has been reported in indiv...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Intraoperative ventilation settings in Germany: an observational multicentre cross-sectional study

Intraoperative lung protective ventilation and, in inhalational anesthesia, minimal fresh gas flow (FGF) are recommended. It remains unclear how these recommendations are transferred to clinical routine. We aimed to assess corresponding anesthesia practices in Germany and raise a...

Torque expression in directly printed and thermoformed clear aligners: a controlled in vitro biomechanical comparison of power ridge effects

Abstract Background Torque control of anterior teeth remains a major challenge in clear aligner therapy. Power ridges have been introduced to improve buccolingual root control; however, their biomechanical performance in directly printed aligners remains insufficiently investigat...

A DNA methylation–based risk score improves prognostic stratification in myelodysplastic neoplasms

Myelodysplastic neoplasms (MDS) are clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and variable risk of progression to acute myeloid leukemia (AML). Although mutational data are already implemented into the most recent MDS risk models, (i.e...

Development of a prediction model for occupational satisfaction among cancer patients following counseling in German psychosocial cancer counseling centers

Abstract A prognostic model was developed and internally validated to predict satisfaction with the occupational situation among cancer patients receiving psychosocial counseling regarding return to work (RTW). Data were collected from outpatient cancer counseling centers in Germ...

Intercellular Transfer of CD155 Mediated by Melanoma Extracellular Vesicles Downregulates DNAM-1 Expression on NK Cells

Melanoma is a highly immunogenic cancer, and immunotherapy is the first-line treatment for patients with advanced disease. However, CD155 overexpression in melanoma has been associated with resistance to immunotherapy. Whether CD155 can be transferred from tumour cells via extrac...

The global cost of schizophrenia: a health economic modelling study

Abstract Background Schizophrenia is a chronic psychiatric disorder that leads to substantial disability, impaired quality of life, and reduced life expectancy. In addition to its profound impact on affected individuals, the disorder places a considerable financial burden on heal...

The orofacial cleft risk gene IRF6 is a target gene of SOX9 in cranial neural crest cells

Abstract Orofacial clefts represent the most prevalent congenital anomalies affecting the craniofacial region. They can be evoked by a disturbed development of either oral epithelium or cranial neural crest-derived mesenchyme, or by disruptions of their interplay. IRF6 is a well-...

Self‐control strategies to reduce meat consumption: An ecological momentary intervention

An increasing number of individuals aim to reduce their meat consumption, but implementing this is challenging. Self-control strategies could support this change; however, their effectiveness remains understudied. This study examines whether providing self-control strategies supp...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Mitochondrial fitness for sustainable male health – a 3PM-guided healthcare innovation

Abstract Male health is much more than only an essential pillar of the sustainable socio-demographic development of each society. To this end, erectile dysfunction, preventable male infertility, and urological cancers (including testicular, bladder, kidney, prostate, and penile o...

PSYCHIATRIC GENOMICS IN CLINICAL PRACTICE IN GERMANY: THE CENTER FOR RARE MENTAL HEALTH DISORDERS IN BONN

Background In routine clinical practice in Germany, the national genetic testing landscape for adults has changed in recent years from the testing of individual candidate genes and gene panels and stepped approaches utilizing different methodologies to a preponderance of whole ex...

Dental spittoon biofilms as reservoirs of antimicrobial resistance: a longitudinal multi-omics study

ABSTRACT Dental chair spittoons are chronically exposed to saliva, aerosols, intermittent water flow, and chemical disinfectants, yet their biofilm ecology and antimicrobial resistance (AMR) dynamics remain poorly defined. We applied longitudinal 16S rRNA gene sequencing, shotgun...

Subclassification of Vieth stage 4 in MRI of the proximal tibial epiphysis: a pilot study for forensic age estimation

Abstract The MRI-based staging system introduced by Vieth et al. has been successfully validated for assessment of the proximal tibial epiphysis. Our previous validation study suggested that additional information regarding completion of the 16th or 18th year of life might be obt...

Neuroradiologic Findings in Patients With S CN2A Disease

SCN2A disease spans a broad clinical spectrum from self-limited (familial) neonatal-infantile epilepsy to severe developmental and epileptic encephalopathies. Systematic characterization of the spectrum of neuroradiologic abnormalities in SCN2A disease has not been performed. Thi...