Universitätsklinikum Aachen

Neuromonitoring of perioperative microembolization and its association with postoperative stroke after carotid endarterectomy

Abstract Purpose This study aims to assess whether perioperative microembolization can identify patients at risk for postoperative stroke. Methods A total of 257 carotid endarterectomy procedures in 254 patients were analyzed (154 symptomatic, 103 asymptomatic). Neuromonitoring,...

New potassium binders: we need them - we do not need them

Abstract New potassium binders may facilitate contemporary chronic kidney disease care by controlling hyperkalemia and thereby facilitating the continued use of kidney- and cardioprotective therapies, particularly renin-angiotensin-aldosterone system inhibitors. The opposing view...

Engineering Gold Nanoconstruct Architecture Dictates Absorption Efficiency and Photoacoustic Imaging Performance

Abstract Photoacoustic (PA) imaging combines the high contrast of optical modalities with the deep-tissue penetration and high-spatial resolution of ultrasound, making it an attractive technique for biomedical imaging. Gold nanoconstructs are among the most widely investigated PA...

Comparison of a New Fully Synthetic Perfusion Solution to Belzer MPS for 24-H Hypothermic Oxygenated Perfusion of Porcine Kidneys: A Feasibility Study.

Background: Kidney transplantation remains the only curative therapy for end-stage renal disease, yet organ shortage limits its impact. Static cold storage of kidney, still widely used because of its cost effectiveness, is often associated with ischemia-reperfusion injury and del...

Real-time Quality Assessment of Donor Kidneys During Normothermic Machine Perfusion Using Perfusate and Urinary Biomarkers.

Background: Objective, real-time criteria for kidney graft quality during normothermic machine perfusion (NMP) are lacking, contributing to subjective acceptance decisions and organ discard. We evaluated real-time perfusate/urinary biomarkers and perfusion parameters during NMP a...

Neuropsychobiological transdiagnostic risk mechanisms for aggression in mental disorders across the life span

Abstract Background Aggression in mental disorders (AMD) is a prevalent symptom, poses difficulties to the clinical setting and has far-reaching societal implications. The biological basis of different manifestations, developmental courses, and disease-specific mechanisms remains...

Distinct Plasma Proteomic Signatures Distinguish MASLD From Non‐Steatotic Individuals but Not From MetALD

ABSTRACT Background and Aims Metabolic dysfunction associated steatotic liver disease (MASLD) is the most prevalent liver disease, yet accurate early detection remains challenging. A particular diagnostic obstacle is distinguishing MASLD from metabolic dysfunction and alcohol‐rel...

CD147 is associated with NF-κB activation during the post-traumatic immune response in a murine trauma model

Abstract Extracellular matrix metalloproteinase inducer (CD147) has been proven to play a crucial role in a variety of inflammatory diseases but has not yet been investigated in trauma. The aim of the study was to investigate the role of CD147 in a murine model of trauma and hemo...

Cell-derived lactate triggers local hydrogelation and phenotype remodelling

Abstract Many tumours release lactate as a major metabolic product and signalling molecule. Here we use lactate flux as an endogenous trigger for covalent hydrogel formation. Phenol-functionalised alginate remains soluble until cell-derived lactate is oxidised by lactate oxidase;...

Development of a monoclonal antibody targeting the calcification blocking factor CBF

Chronic kidney disease (CKD) patients suffer from a multitude of comorbidities, with vascular calcification being a major one. Recently, a new 19 amino acid long peptide, called calcification blocking factor (CBF), inhibiting vascular calcification has been identified. CBF concen...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Selective dependency of CALR-mutant myeloproliferative neoplasms on TYK2 signaling

Abstract Myeloproliferative neoplasms (MPN) are driven by the oncoproteins JAK2V617F, mutant calreticulin (CALR), and mutant thrombopoietin receptor (TPOR; MPL), all of which activate JAK/STAT signaling. While JAK2 signaling is engaged in all MPNs, TYK2 is dispensable for JAK2V61...

Remote intestinal changes following blast-induced thoracic trauma with transient hemorrhagic shock and hind-limb ischemia

Abstract Background The intestine is both a driver and a target of posttraumatic organ dysfunction. However, it remains unclear whether, and to what extent an extra-abdominal trauma, such as thoracic trauma with transient hemorrhagic shock and hind-limb ischemia (THS), provokes r...

Genolator enables protein function interpretation using a multimodal large language model fusing genomic and structural interpretation with natural language interaction

Abstract Background Decoding the genetic code to unveil its genome functionality is a monumental task which would greatly advance the understanding of disease mechanisms and development of targeted treatments. Although large language models (LLMs) have transformed natural languag...

Parvovirus B19 infections in paediatric sickle cell disease patients: Genotype and hydroxyurea treatment influence disease severity

Summary In patients with sickle cell disease (SCD), parvovirus B19 infection (B19V) leads to acute anaemia (aplastic crisis), but may also be associated with other serious complications. We retrospectively analysed clinical data from paediatric SCD patients with B19V infections b...

Annual Research Review: Sex differences in conduct disorder – revisiting existing evidence and exploring future directions

Conduct disorder (CD) is a common psychiatric disorder in youth, characterized by severe and recurrent aggressive and antisocial behaviors and associated with substantial healthcare and societal costs. Rates of CD increase during adolescence in both sexes, with the male‐to‐female...

Host Response Impairs Tissue Integration of a Fibrin Hydrogel Scaffold Containing Poly(ε-caprolactone) Nanofibers for Peripheral Nerve Repair

The development of bioengineered conduits for the repair of large peripheral nerve defects remains challenging. Here, we introduce a biomimetic fibrin hydrogel scaffold containing stacked arrays of aligned poly(ε-caprolactone) (PCL) nanofibers that mimics the naturally forming fi...

Dystonia 3×3: A Training Guideline for Beginners in Botulinum Neurotoxin Treatment of Cervical Dystonia

Cervical dystonia (CD) is a hyperkinetic movement disorder characterized by involuntary muscle contractions leading to abnormal postures of the head and neck. The injection of botulinum neurotoxin type A (BoNT-A) into the muscles involved is the treatment of choice for CD. BoNT-A...

Brugada Syndrome in the Pediatric Population: Diagnostic Challenges and Clinical Outcome—Results of the German Multicenter Study COGIA

ABSTRACT Introduction Diagnosis and treatment of children and adolescents with suspected Brugada syndrome (BrS) is challenging. Aim of the study was to evaluate the applicability of current diagnostic criteria for pediatric patients with suspected BrS in the German multicenter st...

The Global Epidemiology of Metabolic Dysfunction-Associated Steatotic Liver Disease: Regional Hotspots, Trends, and Future Projections

Purpose of Review This review highlights the global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), assesses comparability of the former definition of non-alcoholic fatty liver disease (NAFLD)-era estimates with the 2023 steatotic liver disease (SL...