Intraarterial Thrombolysis: Past, Present, Future
Abstract
Suboptimal clinical outcomes are common after ischemic stroke with large vessel occlusion despite current reperfusion treatment with intravenous thrombolysis and mechanical thrombectomy. Targeting residual distal arterial and microvascular occlusions with intraarterial thrombolysis has recently gained substantial interest as an adjunct to improve cerebral tissue perfusion. While recent trials provide promise in selected patients with anterior-circulation stroke, further high-quality, large-scale studies and pooled individual-patient analyses are needed. This review summarizes the evolving role of intraarterial thrombolysis over the past 3 decades and projects potential developments.
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Authors: Felix Ng, Chengchuan Wu, Ángel Chamorro, Wenjie Zi, Xiaochuan Huo, Bernard Yan, Yamei Tang, Raul G. Nogueira, Zhenhua Zhou, Urs Fischer, Johannes Kaesmacher, Benjamin Gory, Guillaume Turc, Sébastien Richard, Peter Mitchell, Bruce Campbell
Institutions: UPMC Health System, Sun Yat-sen University, Inserm, Army Medical University, Université Paris Cité, University of Bern, Université de Lorraine, Hospital Clínic de Barcelona, Imagerie Adaptative Diagnostique et Interventionnelle, University of Science and Technology of China, University Hospital of Bern, Austin Health, The Royal Melbourne Hospital, Beijing Anzhen Hospital, Southwest Hospital, Institut de Psychiatrie et Neurosciences de Paris, FHU Neurovasc, Centre de Recherche en Sciences et Technologies de l'Information et de la Communication