Beijing Anzhen Hospital

Preoperative red blood cell distribution width is associated with prolonged mechanical ventilation and in-hospital mortality after acute type A aortic dissection repair

Red blood cell distribution width (RDW) has emerged as a potential prognostic marker in cardiovascular diseases. This study aimed to investigate the association between preoperative RDW and the incidence and mortality of prolonged mechanical ventilation (PMV) in patients with acu...

Association and potential mechanisms between maternal amniotic fluid microbiota heterogeneity and fetal complex congenital heart disease

Numerous studies have found that dysbiosis of the microbiota is associated with cardiovascular diseases in humans and shows certain links to congenital heart disease (CHD) in children. However, direct evidence regarding whether maternal gut microbiota is related to fetal heart de...

Protection of beta-blocker and 5-hydroxytryptamine 1A receptor agonist on myocardial ischemia injury in rats by regulating the NLRP3/Caspase-1/GSDMD pathway

Objective To explore the effects and related mechanisms of a β-blocker combined with a 5-hydroxytryptamine 1A receptor (5-HT1AR) agonist on MI injuries in rats. Methods TTC/Evans blue, H&E, Masson, and TUNEL staining were used to assess infarction area, pathological damage, fibro...

Time-Dependent Prognostic Value of the sCD25-to-Ferritin Ratio in Chronic Active Epstein–Barr Virus-Associated Hemophagocytic Lymphohistiocytosis

INTRODUCTION: Chronic active Epstein-Barr virus infection (CAEBV) is an EBV-positive T/NK-cell lymphoproliferative disease characterized by persistent EBV infection in T or NK cells. CAEBV-HLH refers to hemophagocytic lymphohistiocytosis secondary to CAEBV. As important markers o...

Aortic valve replacement with or without concomitant septal myectomy in patients with aortic stenosis and asymmetric septal hypertrophy: a retrospective cohort study

The optimal surgical strategy for patients with severe aortic stenosis (AS) accompanied by asymmetric septal hypertrophy (ASH) remains controversial. This study aimed to evaluate the safety and efficacy of concomitant septal myectomy performed at the time of aortic valve replacem...

A hybrid CNN-transformer network with global-local context feature aggregation for lung medical image segmentation

Accurate lung segmentation is a key prerequisite for computer-aided diagnosis of pulmonary diseases on chest CT and X-ray images. Lung segmentation, however, remains highly challenging due to the complex anatomy of the lung, ambiguous lesion boundaries, low tissue contrast, and t...

Disparities in the management of cardiogenic shock complicating acute myocardial infarction: a questionnaire survey in Beijing

To investigate disparities in the management of cardiogenic shock complicating acute myocardial infarction (AMI-CS) across different hospital levels in Beijing. A standardized questionnaire was electronically distributed to 61 hospitals through the Beijing Cardiovascular Internal...

Urine metabolomics reveals key pathways supporting neuronal regeneration and consciousness recovery in disorders of consciousness

Disorders of consciousness (DoC) are debilitating conditions resulting from severe brain injury, requiring not only structural preservation but also active neuronal regeneration for recovery. These regenerative processes are metabolically demanding and can be tracked through syst...

Triglyceride–glucose body roundness index and risks of incident cardiovascular disease and cardiometabolic multimorbidity: evidence from prospective cohorts in China and England

Cardiovascular disease (CVD) and cardiometabolic multimorbidity (CMM) impose substantial health burdens. The triglyceride–glucose body roundness index (TyG-BRI) integrates metabolic dysfunction reflected by TyG with body-shape information reflected by BRI, but its associations wi...

Enhanced mortality prediction using frailty models in cardiac surgery patients: evidence from the MIMIC-IV database

The Frailty Index based on Laboratory Tests (FI-Lab) and the Hospital Frailty Risk Score (HFRS) represent two frailty measures, yet their comparative and combined prognostic utility in cardiac surgical populations remains unclear. We conducted a retrospective cohort study using t...

Association of the C-reactive protein-triglyceride glucose index with incident hypertension across glycemic status: a longitudinal cohort study

The C-reactive protein-triglyceride glucose index (CTI) is a composite indicator that integrates systemic inflammation, lipid metabolism, and glucose metabolism. Previous studies have reported an association between CTI and incident hypertension, but evidence across different gly...

School-based hygiene intervention to prevent Helicobacter Pylori infection among children (SHIP HOPE): a cluster-randomized controlled trial

Helicobacter pylori ( H. pylori ) is a major cause of gastric cancer and is typically acquired during childhood. Preventing infection in uninfected children is a promising strategy; however, the effectiveness of hygiene-based interventions remains uncertain. This study aimed to d...

From endovascular therapy to perivascular therapy: A new concept and perspective

The cardiovascular system relies on an organ-spanning vascular network not only for transport but also for systemic homeostatic control. Surrounding the vessel wall is a complex perivascular microenvironment, including the vasa vasorum, autonomic and sensory nerves, perivascular...

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

Severe Legionella pneumophila pneumonia complicated by rhabdomyolysis and myocarditis: a case report

Legionella pneumophila is an important cause of severe community-acquired pneumonia and may be accompanied by extrapulmonary abnormalities. Hyponatremia and hepatic biochemical abnormalities are recognized clinical clues, whereas rhabdomyolysis and myocarditis are uncommon compli...

Circulating miR-106b-5p discriminates acute myocardial infarction patients, predicts disease severity, and regulates H/R-induced cardiomyocyte injury by targeting CDKN1A

The early detection, disease monitoring, and prognosis prediction are of great significance for acute myocardial infarction (AMI). This study focused on miR-106b-5p, evaluating its clinical significance in AMI onset and progression. This study enrolled 147 AMI patients with 123 s...

Left ventricular end-diastolic diameter to body surface area ratio as a continuous risk marker in left ventricular non-compaction with a dilated phenotype: a multicenter cross-sectional study

Dilated cardiomyopathy (DCM) is a risk factor for poor outcomes in patients with left ventricular non-compaction (LVNC). This study aims to identify key factors associated with the DCM phenotype in LVNC and develop a risk stratification model. This multicenter cross-sectional stu...

Dynamic Echocardiographic Trajectory Phenotypes During Veno‐Arterial Extracorporeal Membrane Oxygenation and Their Association With In‐Hospital Mortality: A Multicenter Cohort Study

BACKGROUND: Current risk stratification for veno-arterial extracorporeal membrane oxygenation relies on static assessments, ignoring dynamic cardiac evolution. We aimed to identify longitudinal echocardiographic trajectory phenotypes and evaluate their association with in-hospita...

Changes in frailty and incident circadian syndrome in middle-aged and older adults: a nationwide prospective cohort study

Circadian syndrome (CircS) is more predictive than metabolic syndrome (MetS). However, few studies have examined its risk factor. This study aims to investigate whether the static state or dynamic change of frailty is correlated with incident CircS in Chinese adults. Data were ob...

The Effects of Hollow Fiber Membrane Configuration on Hemodynamic Characteristics, Oxygen Transfer Performance and Thrombosis Risk in Oxygenators: A Numerical Research

ABSTRACT Background The effects of hollow fiber membrane (HFM) configuration on hemodynamic characteristics, oxygen transfer performance, and thrombosis risk in oxygenators are not clear, and the present study was accomplished to investigate these effects. Methods Three micro‐sca...