Hospital Clínic de Barcelona

Intraarterial Thrombolysis: Past, Present, Future

Suboptimal clinical outcomes are common after ischemic stroke with large vessel occlusion despite current reperfusion treatment with intravenous thrombolysis and mechanical thrombectomy. Targeting residual distal arterial and microvascular occlusions with intraarterial thrombolys...

Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Reveals Extensive Articular and Extraarticular Rheumatoid Arthritis

Up to 40% of patients with rheumatoid arthritis (RA) develop extraarticular manifestations, including weight loss and persistent fever, which can mimic infection or malignancy.^1,2 A 73-year-old woman with long-standing, previously undiagnosed deforming polyarthritis pr...

Comparing the effect of faecal microbiota and faecal filtrate transplantations on intestinal health in weaned piglets

<title>Abstract</title> Background Faecal microbiota transplantation (FMT) and faecal filtrate transplantation (FFT) have emerged as promising methods to prevent intestinal dysbiosis and diarrhoea in piglets after weaning. The aim of this study was to compare the effects of FMT a...

Sex differences in epidemiology and clinical presentation of glomerular diseases in a nationwide Spanish biopsy registry

Sex differences influence the epidemiology and clinical expression of kidney diseases. Most primary glomerulonephritis shows male predominance, whereas lupus nephritis remains strongly female-biased. Large national cohorts with sex-stratified analyses are limited. We analysed all...

Key recommendations for primary care from the 2026 GOLD update

The Global Initiative for Obstructive Lung Disease (GOLD) has produced yearly recommendations for the diagnosis and management of patients with COPD since 2001. Here, we summarize the key recommendations of the GOLD 2026 document for a primary care audience, highlighting what has...

False Passage During Single-Lung Ventilation in a Tracheostomized Patient: Intraoperative Recognition and Rescue

Objective:Unusual clinical course Background:Airway management in tracheostomized patients may become particularly challenging in the presence of recent stomas, local infection, single-lung ventilation, and restricted intraoperative airway access.False passage ventilation is an u...

Effect of S-equol supplementation on menopausal symptoms, sleep complaints, pain, and work engagement: an exploratory, multicentre open-label study in Spanish women

Although S- equol has demonstrated efficacy in randomized trials conducted mainly in Japanese and American populations, evidence in European populations remains limited. Menopausal symptoms have been shown to negatively affect work productivity and engagement, yet interventions t...

Pituitary neuroendocrine tumors: imaging features, clinical relevance, and a proposal for standardized MRI reporting

Pituitary neuroendocrine tumors (PitNETs) are a heterogeneous group of lesions redefined in the 2022 WHO classification, emphasizing their neuroendocrine nature and biological variability. Despite advances in imaging, radiological reporting of PitNETs remains inconsistent and lac...

Repetitive Transcranial Magnetic Stimulation for Cocaine Use Disorder: An Observational Study

Background: Cocaine use disorder (CUD) presents high relapse rates and limited treatment options. Repetitive transcranial magnetic stimulation (rTMS) has shown promise, but evidence in clinical practice is scarce. Methods: We conducted a naturalistic retrospective study using med...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...

Elucidating the mechanism underlying incomplete immune recovery in people living with HIV through CD4⁺ and CD8⁺ T cell multi-omics

A subset of people living with HIV (PLHIV), known as immunological non-responders (INR), fails to achieve adequate CD4⁺ T cell recovery despite viral suppression with antiretroviral therapy (ART). These individuals face an increased risk of adverse clinical outcomes. This study a...

The Diagnosis and Prenatal Management of Non‐RHD Alloimmunizations

ABSTRACT Red blood cell (RBC) alloimmunization remains a relevant cause of hemolytic disease of the fetus and newborn (HDFN). Although RhD immunization has significantly decreased since the implementation of systematic prophylaxis, it is still the main cause of alloimmunization i...

Burden, perception of stigma, and gender differences among informal care partners of individuals with mild cognitive impairment

Background Caring for individuals with mild cognitive impairment (MCI) is increasingly recognized as a significant clinical challenge. However, the latent burden, driven by perceived stigma and gender-specific vulnerabilities, remains poorly characterized during these early stage...

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Prospecti...

Therapeutic management of axial spondyloarthritis: summary of 2024 update of the Spanish clinical practice guideline (ESPOGUIA)

Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatic disease associated with significant morbidity and impaired quality of life. Rapid advances in diagnosis, monitoring, and especially treatment over the past decade have increased the complexity of axSpA management...

Genetic Testing After Heart Transplantation Uncovers Heritable Disease and Drives Family Screening

BACKGROUND: Genetic testing (GT) is established in ambulatory cardiomyopathy (CM), but its utility after heart transplantation (HTx) recipients remains poorly characterized. OBJECTIVES: This study aimed to evaluate the clinical utility of GT in adult HTx recipients with CM, focus...