Inserm

Schizophrenia research in 2026: report from the annual meeting of the Schizophrenia International Research Society

Abstract SIRS 2026, held under the theme “Schizophrenia Research in the Era of Artificial Intelligence,” brought together researchers, clinicians, and persons with lived experience to take stock of a field whose tools for measuring, predicting, and intervening in psychosis have e...

Optimizing Portal Venous Phase Acquisition Quality of Contrast-Enhanced CT in Oncology

Background: Portal venous phase (PVP) contrast-enhanced CT is a cornerstone for response assessment in early-phase oncology trials, yet contrast-enhancement phase timing remains insufficiently monitored across sites. We assessed PVP timing using a validated artificial intelligenc...

What a highly monitored chikungunya epidemic reveals about preparedness for Europe and beyond

The 2024–25 chikungunya epidemic in Reunion Island illustrates the challenge of translating early warning into timely public-health action during fast-moving arboviral outbreaks. Despite advanced surveillance, the epidemic accelerated rapidly and placed substantial pressure on pr...

Routing to the seizure in postoperative human glioma cortex: spatio-temporal uncoupling between slow and fast extracellular neuronal activities

Abstract Background Diffuse gliomas are frequently associated with epilepsy, particularly in low-grade variants. Seizures are key events to be considered in glioma management, including during surgery. Optimizing resection of epileptic areas may affect not only postoperative epil...

Can machine learning be used to quantify blood loss based on hemodynamic data? Experimental study of controlled hemorrhagic shock in anesthetized piglets

Background Hemorrhagic compensatory physiological mechanisms may initially lead to an underestimation of the severity of a hemorrhage, for which quantification of blood lost volume is difficult. The objective of our study was to assess the suitability of machine learning (ML) to...

Drug allergy de-labelling with a direct oral challenge in outpatient hospital visits

Abstract Although direct oral challenge has been adopted by numerous clinicians worldwide in the context of drug hypersensitivity, drug allergy de-labelling remains largely confined to inpatient or outpatient hospital-based care,mostly for penicillins. In this study, we aim to pe...

Assessing a local vaccination initiative: Eight years of “Immuniser Lyon” in France

“Immuniser Lyon” (IL) is a French city-level initiative launched in 2015 to promote vaccination through coordinated, locally tailored actions. The objective of this study is to describe and compare temporal trends in vaccine coverage for HPV and influenza in the Rhône area versus...

Paraneoplastic podocytopathies with nephrotic syndrome in solid cancers with C-Maf Inducing Protein expression

Abstract Background The main features of minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) associated with solid cancer (paraneoplastic podocytopathy with nephrotic syndrome, PPNS) remain poorly described. Methods In this French retrospective study, we fo...

The petal identity gene PhDEF has a major binding and regulatory action in the epidermis

ABSTRACT In flowering plants, floral organ identity is specified by the combinatorial action of homeotic genes. While the role of these genes in the early specification of organ identity is well established, their late function throughout floral organ development and in specific...

Revisiting Identification Thresholds of Specific Learning Disorders ( SLD ) in Gifted Children ( GC ). A Comparison of Three Groups: Twice‐Exceptional ( TE ) Children, GC Without SLD and Non‐ GC With SLD

ABSTRACT This study investigates assessment of Specific Learning Disorders (SLD) in Twice‐Exceptional (TE) children, gifted children (GC) who also present SLD, in oral and written language domains. Applying the standard threshold for identification (< 7th percentile) to GC often...

Assessing Behavioral and Environmental Facets of Obesity Unobtrusively Utilizing Digital Tools: Introducing the BETTER4U Indicators

ABSTRACT Understanding obesity involves evaluating numerous contributing factors. Collecting the necessary data for this can impose a significant burden on both research participants during clinical studies and real‐life deployments of digital tools aiding obesity management. The...

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...

Longitudinal Modeling of Cardiometabolic Dysfunction in Patients With Type 2 Diabetes Using Item Response Theory

ABSTRACT Cardiometabolic dysfunction in patients with type 2 diabetes (T2D) is reflected by multiple risk factors and cannot be fully characterized by any single biomarker. Item response theory (IRT) provides a framework for integrating observed risk factors into latent measures...

Gene-rich fungus gnat germline-restricted chromosomes are largely transcriptionally quiescent

Germline-restricted chromosomes (GRCs) constitute a unique class of chromosomes confined to germ cells. Arising in multiple evolutionarily distant lineages, GRCs have been identified in three insect families (non-biting midges, gall midges, and fungus gnats), each within the orde...

Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury

BackgroundThe preferred method of renal-replacement therapy for acute kidney injury in critically ill patients remains uncertain. MethodsIn this multicenter, open-label, noninferiority trial, we randomly assigned critically ill adults with acute kidney injury who had indications...

Evaluating the roles of testosterone and sex-linked genes in territorial aggression of sex-reversed XY females in the African pygmy mouse

Sex differences in social aggression are widespread across the animal kingdom, with males typic-ally displaying greater territoriality. While this dimorphism has traditionally been attributed to sex hormones, sex chromosomes can also contribute to it independently of hormonal inf...

Passive ankle exoskeleton assistance selectively modulates triceps surae neural control during balance

Wearable assistive devices have potential to improve human balance, but their effectiveness remains limited by an incomplete understanding of how mechanical assistance influences neuromuscular control. This study aimed to determine the neural adaptations in the control of lower l...

Small interfering RNA targeting protein Z-dependent protease inhibitor improves hemostasis in Von Willebrand factor- and Factor X-deficient mice

Non-factor therapeutics have transformed the treatment paradigm in hemophilia A. Owing to their mode of action, these agents may also provide benefit for other rare bleeding disorders (RBDs) such as von Willebrand disease (VWD)-type 3 and Factor X (FX) deficiency. Targeting prote...

Weight Loss and Long-Term Weight Trajectories After a Structured Nutritional and Behavioral Intervention: A Large Real-World Cohort Study

Background/Objectives: Achieving and maintaining intentional weight loss is a major challenge in routine clinical practice, and real-world evidence is limited. Methods: This retrospective cohort study evaluated initial weight loss in 56,093 adults from a total of 126,659 who comm...

Osteocalcin and impaired cerebral resting-state functional connectivity in postmenopausal osteoporosis: a pilot case-control study

PURPOSE: Postmenopausal osteoporosis and circulating osteocalcin have been suggested to influence brain function. Objectives aim to explore associations between brain network resting-state functional magnetic resonance imaging (fMRI) connectivity, bone status, and circulating ost...