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UPMC Health System
Recent research
- Health & MedicineOpen access
Clinical characteristics and outcome of a cohort of CLL patients with BTK T474 gatekeeper mutation
BTK T474 gatekeeper mutations confer resistance to both commercially approved covalent and non-covalent BTK inhibitors (BTKis) in chronic lymphocytic leukemia (CLL), yet their clinical implications remain poorly characterized. While pirtobrutinib was developed to overcome resista...
- Health & MedicineOpen access
BACKGROUND: Best Case/Worst Case (BC/WC) is a communication tool to support nephrologists and older adults with advanced chronic kidney disease with decisions about dialysis. We compared the effectiveness of training nephrologists to use BC/WC versus usual care on receipt of pall...
- Health & Medicine
Intraarterial Thrombolysis: Past, Present, Future
Suboptimal clinical outcomes are common after ischemic stroke with large vessel occlusion despite current reperfusion treatment with intravenous thrombolysis and mechanical thrombectomy. Targeting residual distal arterial and microvascular occlusions with intraarterial thrombolys...
- Physics & SpaceOpen access
Abstract We investigate dwarf satellite systems around massive centrals analogs (Milky Way to Centaurus A) in the NewHorizon simulation. Using simple estimators limiting overdetection, we identify planes of satellites comparable to observations in 30%–70% of cases. The full sampl...
- BiologyOpen access
A dependency map enhanced with next-generation 3D cancer models
Despite advances in precision oncology, effective personalized treatments are still lacking for most patients with cancer1. The Cancer Dependency Map (DepMap) accelerates this field by systematically identifying cancer vulnerabilities in diverse preclinical models. Data from over...
- Biology
Aldose reductase as a regulator of ocular pathology: Mechanisms and therapeutic potential.
Aldose reductase (AR), the rate-limiting enzyme of the polyol pathway, converts glucose to sorbitol using NADPH and becomes markedly overactive under hyperglycemic conditions. Its widespread expression in ocular tissues links AR to numerous eye disorders through sorbitol accumula...