Southwest Hospital

NIR‐Light‐Activable Macrophage Polarization Orchestration Using Laser‐Structured Janus Nanoplatform Derived from Waste for Infected Wound Healing

ABSTRACT The human skin is highly susceptible to bacterial infections and inflammation when its integrity is disrupted. Treatment of infected wounds is a big challenge in modern medicine, and rising antibiotic resistance motivates the development of antibiotic‐free therapies. Her...

Engineered CeO 2−x /Au Nanocomposite Enabled Colorimetric‐Terahertz Bimodal Sensing of Urinary Tract Infection Pathogens

ABSTRACT The integration of rapid on‐site screening with precise quantification is critically important for the diagnosis of urinary tract infections (UTIs). However, current detection methods often struggle to balance between screening efficiency and quantitative accuracy. Herei...

Intraarterial Thrombolysis: Past, Present, Future

Suboptimal clinical outcomes are common after ischemic stroke with large vessel occlusion despite current reperfusion treatment with intravenous thrombolysis and mechanical thrombectomy. Targeting residual distal arterial and microvascular occlusions with intraarterial thrombolys...

Phosphorylation of OTUB1 promotes autophagy initiation under starvation

Eukaryotes initiate autophagy in response to environmental challenges such as nutrient deprivation. However, the mechanisms governing autophagy initiation remain incompletely understood. Here, we demonstrated that OTUB1 phosphorylation plays a key role in starvation-induced autop...

Correlation between CYP2B6 exonic gene polymorphisms and efavirenz plasma concentrations in Yi ethnic HIV/AIDS patients: a study from Sichuan province, China

Polymorphisms in the CYP2B6 Gene significantly impact efavirenz (EFV) metabolism and plasma levels, resulting in variability in both treatment effectiveness and toxicity among individuals. In this study, we aimed to evaluate the relationship between the CYP2B6 polymorphisms and t...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Repetitive transcranial magnetic stimulation normalizes cerebrocerebellar loop functional connectivity in spinocerebellar ataxia type 3

Abstract Background Spinocerebellar ataxia type 3 (SCA3) is a rare neurodegenerative disorder characterized by ataxia; structural and functional damage to the cerebrocerebellar loop play key roles in its pathology. However, effective treatments for SCA3 remain limited. Repetitive...

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy is largely ineffective in most solid tumors, partially because of inadequate intratumoral trafficking. Bridging therapy, administered between leukapheresis and CAR‐T cell infusion, offers a distinct opportunity to control th...

Age-related prognostic disparities in cutaneous melanoma: A population-based study and validated interactive web-based nomogram for individualized prognostic stratification

Background Cutaneous melanoma (CM) in older adults (≥65 years) has distinct clinicopathological features and poorer survival than in younger adults. We evaluated age-related cancer-specific survival (CSS), prognostic associations, and an interactive web-based nomogram. Methods We...

RPPH1 drives ovarian cancer cells proliferation via CDK9-c-Myc axis

Dysregulation of the proto-oncogene c-Myc is a critical driver of ovarian cancer progression, yet the mechanisms governing its expression remain incompletely characterized. A systematic bioinformatic analysis was used to screen long non-coding RNA involved in the regulation of c-...