Army Medical University

The Application Potential and Future Challenges of Plant-Derived Exosome-like Nanoparticles in the Treatment of Liver Diseases

Liver disease is a serious global health challenge, with high morbidity and mortality that put significant socioeconomic stress on society. Despite therapeutic advances, current regimens have been limited by rapid drug resistance and insufficient targeting accuracy, and there is...

Network pharmacology and metabolomics analysis of ginsenosides in fibrinolysis balance after hip arthroplasty

Abstract Total hip arthroplasty (THA) is an effective treatment for end‑stage hip disease. However, postoperative fibrinolytic imbalance is common and increases the risks of bleeding and thrombosis. Ginsenosides, the main active constituents of Panax ginseng , exhibit multiple ph...

Hydrogen-Associated CXCL2 Drives Adaptive Inflammatory-to-Proliferative State Transition during Skin Wound Healing

Abstract Background Wound healing is an environmentally adaptive process. It requires a tightly coordinated transition from an inflammatory to a proliferative state, which occurs in response to oxidative and inflammatory stress. Molecular hydrogen (H2) is a widely recognized medi...

IgG depletion by FcRn blockade is associated with changes in amyloid pathology and neurodegeneration in APP/PS1 mice

Abstract Background Autoimmune disorders are associated with an increased risk of developing Alzheimer’s Disease (AD). Dysregulated autoantibodies have been suggested to contribute to exacerbated amyloid-beta (Aβ) accumulation. Based on the potential contribution of humoral immun...

Efficacy, Efficiency, and Safety of a Poly-L-lactic Acid Cuff Tube Assisting for Microvascular Anastomosis

BACKGROUND: Vascular anastomosis is a cornerstone of microsurgery. Anastomosis time and vessel patency significantly influence surgical success. The disadvantages of the traditional hand-sewn method requires a high technical threshold, prolonged surgical time, and an increased ri...

NDRG2 as a Promising Therapeutic Target in Depression: A Review of its Multifaceted Mechanisms

Depression is a common mood disorder with limited treatment efficacy. N-myc downstream-regulated gene 2 (NDRG2) is a stress-responsive molecule expressed in astrocytes and has been recognized as a key regulator in depression; however, its underlying mechanisms remain largely uncl...

Development and Validation of a Novel Contact Force‐Integrated Pulsed Field Quantization Index for Pulmonary Vein Isolation in a Porcine Model

ABSTRACT Introduction There is no bipolar‐specific quantitative ablation index currently available to guide pulsed field ablation (PFA). We aimed to develop and validate a novel contact force (CF)‐integrated pulsed field quantization index (PFQI) for real‐time lesion depth predic...

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

ABSTRACT Spinal cord injury (SCI) induces secondary brain pathology, but the mechanisms linking spinal and brain injury remain unclear. Here, we identify meningeal lymphatic dysfunction as a contributor to secondary brain pathology after SCI. In mice, meningeal lymphatic vessels...

Research on effective quantitative indicators of medical mentors’ academic cooperation to improve their development

Academic collaboration not only directly benefits mentors’ performance but also positively impacts postgraduates’ development indirectly. This study aims to explore indicators that can effectively quantify the collaboration among medical mentors, thereby providing guidance for th...

A nomogram for differentiating false-negative from true-negative diagnoses following non-diagnostic CT-guided lung biopsy

This study aimed to develop and validate a nomogram that integrates clinical data, radiological findings, and biopsy procedural characteristics to distinguish false-negative from true-negative diagnoses in patients with non-diagnostic results following CT-guided lung biopsy. This...

Identification and validation of biomarkers related to integrated stress response in ischemic stroke based on transcriptomics

Abstract Ischemic stroke (IS) is a prevalent cerebrovascular disorder. Integrated stress response (ISR) plays an important role in multiple cerebrovascular diseases, its specific involvement and associated biomarkers in IS remain incompletely understood. This study aimed to ident...

Hollow Silica/PUU Composites for Flame Retardancy and Blast Mitigation: From Shock Tube to In Vivo Protection

Abstract Blast shock waves and the resulting thermal burns from secondary fires are among the primary causes of casualties in explosions, underscoring the significance of developing protective materials that simultaneously deliver efficient shock wave attenuation and flame retard...

Gut microbiome enterotypes associate with distinct metabolomic landscapes and clinical outcomes in inflammatory bowel disease: a multi‑omics dissection

The gut microbiota contributes to inflammatory bowel disease (IBD), but patient‑to‑patient variation in microbial dysbiosis remains poorly characterised. The gut‑brain axis is implicated in the high rate of psychiatric comorbidities in IBD, though the microbial and metabolic medi...

Orthogonal Light‐ and Enzyme‐Triggered and‐Gate Prodrugs for Senolytic Therapy

ABSTRACT Senescence‐associated β‐galactosidase (SA‐β‐gal) is widely used to target senescent cells, but its activity in non‐senescent tissues can limit selectivity. Here, we developed a light–enzyme AND‐gate strategy in which an o‐nitrobenzyl photocage blocks β‐galactoside cleava...

Mitochondria-Targeted Prodrug Nanoassemblies Elicit Antitumor Immunity via Mitophagy-Boosted Ferroptosis in Triple-Negative Breast Cancer

Abstract Ferroptosis, an immunogenic iron-dependent cell death driven by lipid peroxidation, holds promise for treating triple-negative breast cancer (TNBC). However, its efficacy is severely compromised by restricted iron availability and the potent GPX4/GSH defense system. Here...

Proximity of anterior mediastinal tumors to the left innominate vein as a predictor of surgical difficulty in subxiphoid VATS: a retrospective analysis

Subxiphoid video-assisted thoracoscopic surgery (SVATS) is widely used for anterior mediastinal tumor resection, yet proximity to major vessels creates technical challenges. This study quantifies how the vertical distance between the tumor and the left innominate vein (LIV) predi...

Network pharmacology, single-cell transcriptomics, machine learning and experimental validation identifying CHEK2 and HPGD as key therapeutic targets of berberine in diabetic nephropathy

Diabetic nephropathy (DN) is a severe microvascular complication of diabetes with limited therapeutic options. Berberine exhibits renoprotective potential, yet its precise molecular targets and mechanisms of action in DN remain unclear. Berberine targets were retrieved from TCMSP...

SIRT2-mediated deacetylation of ANT3 at Lys96 promotes cell death

Abstract ANT3 is a key molecule that constitutes the mitochondrial permeability transition pore (mPTP) and mediates cell death. Disruption or conformational changes in ANT3 protein homeostasis can trigger cell death. However, the molecular mechanism of ANT3 protein homeostasis re...

Development and Validation of Daping Orthopedics Operative Risk Scoring System for Geriatric Hip Fracture ( DOORS ‐ GHF ) for Predicting Postoperative Outcomes in Geriatric Hip Fracture Patients: A Multicenter Retrospective Comparative Study

ABSTRACT Objective With China's accelerating population aging, geriatric hip fractures pose a growing clinical challenge. High comorbidity burden and diminished physiological reserve drive elevated postoperative complication and mortality risks in this population. However, most e...

Distinct Nodal Centrality and Connectivity Profiles Underlying Independent and Interdependent Self-Construal: A Graph-Theoretical Resting-State fMRI Study

Background/Objectives: Self-construal—the extent to which the self is construed as autonomous from or connected with others—shapes cognition and social behavior, yet its system-level neural architecture remains poorly understood. This study examined whether independent and interd...