Army Medical University

Bone cement pulmonary and intracardiac embolism following percutaneous vertebroplasty: a case report and literature review

Pulmonary embolism and intracardiac cement embolism caused by venous leakage of bone cement are the most serious complications following percutaneous vertebroplasty. Although the incidence of such events is low, they are insidious due to variable clinical symptoms, prone to being...

Structural and functional insights into QueC-family protein in QatABCD anti-phage system

Abstract QatABCD is a widespread prokaryotic anti-phage defense system comprising four protein components, out of which QatC, a QueC-family protein is the signature component. QueC family proteins are nucleoside biosynthesis enzymes involved in the biosynthesis of queuosine, a 7-...

Research on an Interpretable Grey Wolf Optimization-Based Ensemble Machine Learning Model for Identifying Heterogeneity of Bladder Cancer Based on Immunological Microenvironment

Abstract Bladder urothelial carcinoma (BLCA) exhibits marked heterogeneity, leading to variable treatment responses and prognoses across subtypes. Current molecular classification systems lack emphasis on immune-related genes, limiting their utility for guiding immunotherapy. Usi...

Ticagrelor-Aspirin With Thrombolysis by Infarct Patterns in Moderate Ischemic Stroke: TAPIS Subgroup Analysis

BACKGROUND: Whether diffusion‑weighted imaging infarction patterns influence the efficacy and safety of early oral ticagrelor‑aspirin with intravenous thrombolysis in moderate acute ischemic stroke is uncertain. We assessed treatment effects by infarction pattern in this thrombol...

Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate

Cardiovascular-kidney-metabolic (CKM) syndrome and cardiometabolic multimorbidity (CMM) carry substantial mortality, yet whether a composite index integrating insulin resistance and frailty shows stronger associations with advanced CKM syndrome, CMM, and mortality than convention...

Comparative evaluation of selective media and key factors affecting isolation of V. cholerae and V. parahaemolyticus

Abstract Thiosulfate citrate bile salts sucrose (TCBS) agar is a widely used selective medium for the presumptive isolation of Vibrio spp, playing an essential role in food safety and public health surveillance. However, variations among commercial formulations may significantly...

Impaired amyloid-beta uptake and distinct transcriptomic profiles of monocytes in APOE4 carriers: The Chongqing Ageing and Dementia Study

The ε4 allele of the apolipoprotein E gene (APOE4) is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). However, its impact on monocyte-mediated amyloid-β (Aβ) clearance and associated immune dysfunction remains poorly understood. Through Aβ uptake assays i...

52‐week ivarmacitinib in moderate‐to‐severe atopic dermatitis: A phase 3 trial

BACKGROUND: Ivarmacitinib, an oral JAK1 inhibitor, improved efficacy outcomes versus placebo at Week 16 in a phase 3 trial in patients with moderate-to-severe atopic dermatitis (AD). OBJECTIVES: To describe efficacy and safety outcomes through Week 52. METHODS: In this multicentr...

Familial aggregation of cardiometabolic traits and long-term cardiometabolic risk in offspring: a 15-year prospective analysis from the PREVEND cohort

Family history is a well-established predictor of cardiometabolic risk; however, the independent prognostic contribution of sibling disease history, beyond parental history, remains to be elucidated. Using data from the prospective population-based Prevention of Renal and Vascula...

Transepithelial potential as a novel biomarker and therapeutic target for epithelial disease and regeneration

The transepithelial potential (TEP) is a stable, long-range bioelectrical gradient maintained across epithelial barriers, generated primarily by polarized ion transport mechanisms such as the Na⁺/K⁺-ATPase and epithelial sodium channels (ENaC). Ranging from a few millivolts to ov...

Correlation Between CT Manifestations and Treatment Strategy in Nasal Bone Fractures

Objective: To determine the association between detailed CT manifestations of nasal bone fracture and treatment strategy, emphasizing whether CT-derived structural severity can stratify conservative treatment, closed reduction, and open reduction/septorhinoplasty. Methods: This r...

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression

Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p‐tau217) in Alzheimer's disease (AD) remains uncertain. METHODS In this multi‐cohort study of 2117 individuals, we established baseline plasma p‐tau217 thresholds for amyloid‐β...

Candidate role of ADAMTS2 in regulating keratinocyte apoptosis via indirect NF-κB modulation in life-threatening PD-1 inhibitor-induced TEN-like cutaneous toxicity

Abstract Toxic epidermal necrolysis-like (TEN-like) immune-related cutaneous adverse event (ircAE) induced by programmed death 1 (PD-1) inhibitors is life-threatening; however, its pathogenesis remains unclear. This study aimed to dynamically characterize molecular signatures and...

Patient with repeated cerebral vascular occlusion receive three thrombolysis and two endovascular treatments within 103 hours: a case report

Restoring blood flow through intravenous thrombolysis (IVT) or endovascular treatment (EVT) is the most effective therapy for acute ischemic stroke (AIS). However, reocclusion remains a common complication in patients who achieve successful revascularization. Currently, there is...

Association between beta-blocker selectivity and mortality in left heart failure patients with comorbid COPD

To evaluate the Impact of posterior to intensive care unit (ICU) beta-blockers use with the clinical outcomes in patients with left heart failure(LHF) and chronic obstructive pulmonary disease(COPD). Patients with LHF and COPD were selected from the Medical Information Mart for I...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

A Novel Preclinical Rat Model of Acute Compartment Syndrome

Acute compartment syndrome (ACS) is common in trauma, challenging early diagnosis and treatment. An accurate ACS model is vital for its management. Most prior animal models have induced intrafascial hypertension by exogenous interventions, focusing on the study of secondary injur...

Engineered CeO 2−x /Au Nanocomposite Enabled Colorimetric‐Terahertz Bimodal Sensing of Urinary Tract Infection Pathogens

ABSTRACT The integration of rapid on‐site screening with precise quantification is critically important for the diagnosis of urinary tract infections (UTIs). However, current detection methods often struggle to balance between screening efficiency and quantitative accuracy. Herei...

NIR‐Light‐Activable Macrophage Polarization Orchestration Using Laser‐Structured Janus Nanoplatform Derived from Waste for Infected Wound Healing

ABSTRACT The human skin is highly susceptible to bacterial infections and inflammation when its integrity is disrupted. Treatment of infected wounds is a big challenge in modern medicine, and rising antibiotic resistance motivates the development of antibiotic‐free therapies. Her...

Intraarterial Thrombolysis: Past, Present, Future

Suboptimal clinical outcomes are common after ischemic stroke with large vessel occlusion despite current reperfusion treatment with intravenous thrombolysis and mechanical thrombectomy. Targeting residual distal arterial and microvascular occlusions with intraarterial thrombolys...