Visible mould and blood inflammatory phenotypes of asthma in adults: the CONSTANCES cohort
Abstract
Studying the associations between indoor mould contamination and blood inflammatory phenotypes may provide further insight into the mechanisms by which this environmental factor affects asthma. Among 1870 adults with current asthma from a population-based cohort, 29.6% reported visible mould in the dwelling. Paucigranulocytic (reference category), neutrophilic, eosinophilic and mixed phenotypes accounted for 58.8%, 3.8%, 34.5% and 2.9%, respectively. Visible mould was consistently associated with eosinophilic phenotype (OR 1.30 (95% CI 1.04 to 1.63)) whatever the analyses, with no heterogeneity by sex. Our findings suggest that mould contamination may contribute to type 2 inflammation, offering mechanistic insight into the effect of mould on asthma in adults.
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Authors: Tajidine Tsiavia, Joseph Henny, Emilie Fréalle, Marcel Goldberg, Céline Ribet, Marie Zins, Nicolas Roche, Bénédicte Leynaert, Laurent Orsi, Rachel Nadif
Institutions: Inserm, Université Paris Cité, Sorbonne Université, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Université Sorbonne Paris Nord, Sorbonne Paris Cité, Centre de Recherche Épidémiologie et Statistique, Assistance Publique – Hôpitaux de Paris, Université Paris-Saclay, Université de Lille, Centre Hospitalier Universitaire de Lille, Université d'Artois, Université de Versailles Saint-Quentin-en-Yvelines, Centre de recherche en Epidémiologie et Santé des Populations, Institut Cochin, Université Paris-Sud, IMT Nord Europe, Hôtel-Dieu de Paris, Hôpital Cochin