Université Sorbonne Paris Nord

Impact of a High‐Fiber, Fruitless Diet on the Gut Microbiome, and Health of Captive Orangutans

ABSTRACT Diet is a crucial factor in modulating the gut microbiome, and understanding these interactions in captive primates is essential for their health and welfare. This study assessed the impact of the transition to a high‐fiber, low‐sugar diet on the gut microbiome, behavior...

Longitudinal Modeling of Cardiometabolic Dysfunction in Patients With Type 2 Diabetes Using Item Response Theory

ABSTRACT Cardiometabolic dysfunction in patients with type 2 diabetes (T2D) is reflected by multiple risk factors and cannot be fully characterized by any single biomarker. Item response theory (IRT) provides a framework for integrating observed risk factors into latent measures...

Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury

BackgroundThe preferred method of renal-replacement therapy for acute kidney injury in critically ill patients remains uncertain. MethodsIn this multicenter, open-label, noninferiority trial, we randomly assigned critically ill adults with acute kidney injury who had indications...

Thermoelasticity of mixed-mode cracks in layered transversely isotropic half-spaces

A three-dimensional spectral formulation is developed for steady thermoelastic penny-shaped cracks embedded in layered transversely isotropic half-spaces, with arbitrary stacking sequences and mechanically compliant and thermally resistive interfaces. Its central feature is a com...

Nonparametric Hazard Rate Estimation With Associated Kernels and Minimax Bandwidth Choice

ABSTRACT In this paper, we introduce a general theoretical framework for nonparametric hazard rate estimation using associated kernels, whose shapes depend on the point of estimation. Within this framework, we establish rigorous asymptotic results, including a second‐order expans...

Reach and engagement in the ECAIL trial targeting socially disadvantaged families across the COVID-19 pandemic and cost-of-living crisis: A mixed-methods implementation study

Background The ECAIL trial, launched in 2017, was designed to evaluate a multicomponent intervention for childhood obesity prevention among hard-to-reach families. At a maternity hospital in Lille, France, healthcare providers screened pregnant women experiencing social vulnerabi...

Escherichia coli ST131 isolates are rare in human meningitis but belong to a distinct O25b-fimH22 clade B lineage shared with avian pathogenic Escherichia coli

Escherichia coli ST131 is a globally disseminated extraintestinal lineage best known for its resistance-driven expansion, yet it is rarely reported as a cause of neonatal meningitis. Whether specific ST131 sublineages retain neuroinvasive potential remains poorly understood. We a...

Effective Young’s modulus of a unidirectional fiber reinforced composite: a mean Green operator interpretation

Abstract Experimental measurements of the effective Young’s modulus of an unidirectional composite obtained by embedding 3D-printed PLA–CF fibers in a cold-curing polyurethane elastomeric matrix are presented. Specimens with a controlled number of aligned fibers were tested in un...

Rule‐Based Versus Generative Extraction of Psychological Symptoms From Forensic Medical Certificates: A Feasibility Study in the French ORFeAD Network

ABSTRACT Forensic medical certificates for victims of interpersonal violence describe psychological symptoms in unstructured prose, rarely explicit and requiring inference. To assess the feasibility of two extraction pipelines—rule‐based and a locally served generative large lang...

Non-Deterministic Abstract Machines

We present a generic design of abstract machines for non-deterministic programming languages such as process calculi or the lambda calculus with full non-deterministic \(\beta\) -reduction. Such a machine traverses a term in the search for a redex, making non-deterministic choice...

A Decomposition Approach for Large Virtual Network Embedding

ABSTRACT Virtual Network Embedding (VNE) is the core combinatorial problem of Network Slicing, a 5G technology which enables telecommunication operators to propose diverse service‐dedicated virtual networks, embedded onto a common substrate network. VNE asks for a minimum‐cost ma...

Mild stimulated cycles with timed intercourse in women with idiopathic infertility and decreased ovarian reserve: can it be a therapeutic option before oocyte donation?

Woman natural fertility declines physiologically with age, driven by accelerated follicular depletion and subtle ovulatory dysfunctions. As age at first pregnancy increases, women with decreased ovarian reserve (DOR) represent a growing proportion of those seeking assisted reprod...

Are older adults in China living longer happy years? A cohort-based multistate analysis, 2002–2018

Abstract China’s rapid population ageing raises the question of whether added years of life are also happy years. Using data from the Chinese Longitudinal Healthy Longevity Survey (2002–2018), we applied a cohort-based multistate life table method to estimate partial-cohort happy...

Probiotics and Risk of Death, Necrotizing Enterocolitis, and Sepsis in Very Preterm Infants

Importance Probiotics are reported to benefit preterm infants, but population-based clinical evidence is limited. In 2020, the Swedish Neonatal Society issued a national recommendation to supplement very preterm infants (28 weeks 0 days’ to 31 weeks 6 days’ gestation) with probio...

A native dairy-derived Streptococcus thermophilus potentiates docetaxel efficacy by modulating apoptotic and PI3K/AKT/mTOR signaling pathways in MCF-7 breast cancer cells

Docetaxel (DTX) is a widely used chemotherapeutic agent for breast cancer; however, its clinical application is limited by dose-dependent toxicity and chemoresistance. This study investigated the chemosensitizing potential of a native dairy-derived S. thermophilus strain in combi...

Lifetime exposure to atypical working hours among healthcare professionals compared with the workforce in other sectors: Nationwide cohort study

Background Despite well-documented health risks, cumulative exposure to atypical working hours (AWH) over a career remains poorly quantified, especially among healthcare workers. Objectives This study aimed to compare career-long AWH exposure among healthcare professionals and ot...

Differentiable latent structure discovery for interpretable forecasting in clinical time series

Abstract Background Timely, uncertainty-aware forecasting from irregular electronic health records (EHR) can support critical-care decisions, yet most approaches either impute to a grid or sacrifice interpretability. We introduce StructGP, a continuous-time multi-task Gaussian pr...

Local and Systemic Risk Factors of Dental Biofilm‐Induced Gingivitis and Their Control: A Systematic Review

ABSTRACT Objectives To identify local and systemic risk factors/indicators for dental biofilm‐induced gingivitis (DB‐GI) and to summarize evidence for their control. Methods A systematic review was undertaken following Preferred Reporting Items for Systematic Review and Meta‐Anal...

The NPIS model: a consensus-based framework for evaluating non-pharmacological interventions

The term non-pharmacological intervention (NPI) refers to health prevention and care protocols supervised by healthcare professionals. However, no precise and widely adopted definition currently exists. Additionally, unlike drugs, NPIs do not have a global evaluation framework be...

Resolving Peptide-Based Supramolecular Architecture Emerging at Reactive Copper/Water Interface

Abstract Understanding how molecular interactions evolve into ordered architectures at reactive solid/liquid interfaces remains a major challenge because surface reactivity can profoundly influence adsorption mechanisms. In such systems, multiple interfacial processes, including...