Centre de Recherche Épidémiologie et Statistique

Development and evaluation of a quality assessment tool for equality, diversity, and inclusion (QUALITY-EDI) within healthcare research

Implementing equality, diversity, and inclusion (EDI) in healthcare research is critical to ensuring findings are translatable and provide the greatest benefit to patients who need it most. A quality assessment scoring tool (QUALITY-EDI) was developed to evaluate the conduct of E...

Lifetime exposure to atypical working hours among healthcare professionals compared with the workforce in other sectors: Nationwide cohort study

Background Despite well-documented health risks, cumulative exposure to atypical working hours (AWH) over a career remains poorly quantified, especially among healthcare workers. Objectives This study aimed to compare career-long AWH exposure among healthcare professionals and ot...

The NPIS model: a consensus-based framework for evaluating non-pharmacological interventions

The term non-pharmacological intervention (NPI) refers to health prevention and care protocols supervised by healthcare professionals. However, no precise and widely adopted definition currently exists. Additionally, unlike drugs, NPIs do not have a global evaluation framework be...

Prediagnostic circulating 25-hydroxyvitamin D and prostate cancer-specific survival: a collaborative pooled analysis of 13 prospective studies

Abstract Background Previous research suggests higher risk of prostate cancer diagnosis in men with high vitamin D serology, but there are limited data related to prostate cancer survival. In this study, we examine the associations between prediagnostic circulating levels of 25-h...

Chance of live birth in women with recurrent pregnancy loss referred to a French assisted reproductive technology center

Recurrent pregnancy loss (RPL) is a multifactorial condition, with over 50% of cases remaining unexplained. The absence of therapeutic consensus raises questions regarding referral for assisted reproductive technology (ART). To evaluate live birth rates and predictors of success...

Frailty before disease onset: risk of mortality and chronic conditions in disease-free middle-aged adults

Abstract Frailty, defined by multisystem physiological decline and heightened vulnerability to stressors, is typically associated with aging and chronic disease. However, its relevance in apparently healthy individuals remains poorly understood. Identifying frailty in this popula...

Visible mould and blood inflammatory phenotypes of asthma in adults: the CONSTANCES cohort

Studying the associations between indoor mould contamination and blood inflammatory phenotypes may provide further insight into the mechanisms by which this environmental factor affects asthma. Among 1870 adults with current asthma from a population-based cohort, 29.6% reported v...

Alcohol and tobacco in cancer: A unified framework of interaction across carcinogenic pathways and cancer types

Background Alcohol and tobacco are among the leading preventable causes of cancer worldwide and frequently co-occur. While both are well-established independent carcinogens, their combined effects remain insufficiently characterized and inconsistently interpreted across cancer ty...