Université Paris-Sud

Small interfering RNA targeting protein Z-dependent protease inhibitor improves hemostasis in Von Willebrand factor- and Factor X-deficient mice

Non-factor therapeutics have transformed the treatment paradigm in hemophilia A. Owing to their mode of action, these agents may also provide benefit for other rare bleeding disorders (RBDs) such as von Willebrand disease (VWD)-type 3 and Factor X (FX) deficiency. Targeting prote...

Universal random matrix behavior of a Fermionic quantum gas

Since its initial use by Wigner in describing heavy atom spectra, random matrix theory (RMT) has found applications and revealed universal laws in diverse physical contexts, from quantum field theory to disordered systems and wireless communications. A particularly compelling app...

Re-schooling as a major outcome of « therapeutic and schooling » programs for adolescents with obesity

Background School absenteeism is a frequent but underrecognized consequence of adolescent obesity, with long-term implications for social and professional integration. Objectives To assess changes in school attendance among adolescents with complex obesity before and after partic...

Association of cryptic pregnancy and alcohol consumption with fetal alcohol spectrum disorder: a nationwide population-based study of 5 million women in 2015–2022

Cryptic pregnancy (CP) also known as pregnancy denial remains an underexplored risk factor for FASD. To our knowledge, there is no available epidemiologic data in the scientific literature exploring the association between CP and FASD. This study aimed to examine the association...

Limitations of routine hepatitis E virus diagnosis in Central African Republic: a comparative evaluation of serological and molecular assays

In the Central African Republic (CAR), data on the disease burden of hepatitis E virus (HEV) infection are limited despite recurrent epidemics. HEV is not routinely tested for in cases of elevated transaminases. Our objective was to evaluate the sensitivity and the specificity of...

Power-law creep in C–S–H emerging from subdiffusive dynamics

Power-laws have long been used to describe creep in cementitious systems, from C-S-H to concrete, yet their mechanistic origin remains unclear. Diffusion, layer sliding, and permeation are often invoked as microscopic drivers of creep in C-S-H, but it is uncertain whether these r...

Visible mould and blood inflammatory phenotypes of asthma in adults: the CONSTANCES cohort

Studying the associations between indoor mould contamination and blood inflammatory phenotypes may provide further insight into the mechanisms by which this environmental factor affects asthma. Among 1870 adults with current asthma from a population-based cohort, 29.6% reported v...