Sorbonne Paris Cité

Routing to the seizure in postoperative human glioma cortex: spatio-temporal uncoupling between slow and fast extracellular neuronal activities

Abstract Background Diffuse gliomas are frequently associated with epilepsy, particularly in low-grade variants. Seizures are key events to be considered in glioma management, including during surgery. Optimizing resection of epileptic areas may affect not only postoperative epil...

DaiSy: A Library for Scalable Data Series Similarity Search

Exact similarity search over large collections of data series is a fundamental operation in modern applications, yet existing solutions are often fragmented, specialized, or tailored to specific execution environments. In this paper, we present DaiSy, a unified library for exact...

Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury

BackgroundThe preferred method of renal-replacement therapy for acute kidney injury in critically ill patients remains uncertain. MethodsIn this multicenter, open-label, noninferiority trial, we randomly assigned critically ill adults with acute kidney injury who had indications...

Pure Shift 2D NMR with Water Suppression for Structural and Dynamic Analysis of Flexible Molecules

Abstract Achieving high-resolution proton NMR spectra in aqueous media remains a major challenge for structurally complex and conformationally flexible molecules, where homonuclear scalar couplings and limited chemical-shift dispersion lead to severe spectral congestion. Here, we...

Energy expenditure of bonobos across their locomotor repertoire

Unlike quadrupedal mammals, primates use diverse locomotor modes adapted to arboreal environments. Such diversity of movements challenges allometric models, which underestimate energetic costs by focusing on steady-state walking. To address this, we combined ethological and biome...

Hackathon on predictive modelling in systems pharmacology: design, implementation, and outcomes

Background The growing availability of multi-omics data and machine learning methods creates both an opportunity and a challenge for the systems pharmacology community: the opportunity to model drug action at unprecedented mechanistic resolution, and the challenge of equipping a...

Guidelines for Decisions to Withhold or Withdraw Life-Sustaining Treatments (LST) in Adult ICU

OBJECTIVE: The French Society of Anaesthesia and Intensive Care Medicine (Société française d'anesthésie et de réanimation, SFAR) and the French Society of Physical Medicine and Rehabilitation (Société Française de Médecine Physique et de Réadaptation (SOFMER)) aimed at providing...

RENOVATE Healthcare Ireland & Ukraine: Economic protocol for comparative cost-effectiveness of available health interventions for depression, according to symptom severity

Background Depression is a leading cause of disability worldwide, associated with reduced quality-of-life and significant economic costs. While NICE has recommended first-line pharmacological, psychological and physical interventions for adults with less severe (subthreshold/mild...

Extriangulated structures from stability conditions and application to braid representations

We use the notion of Bridgeland stability condition and an associated rank function to endow triangulated categories with extriangulated structures and study their extriangulated Grothendieck groups. This study is motivated by Khovanov–Seidel’s categorification of the Burau repre...

Reach and engagement in the ECAIL trial targeting socially disadvantaged families across the COVID-19 pandemic and cost-of-living crisis: A mixed-methods implementation study

Background The ECAIL trial, launched in 2017, was designed to evaluate a multicomponent intervention for childhood obesity prevention among hard-to-reach families. At a maternity hospital in Lille, France, healthcare providers screened pregnant women experiencing social vulnerabi...

Characterization of Thermal Recovery Activation in Fast Photochromic Flavoprotein Charge-Transfer Complexes

Abstract A promising fast, negative, red-absorbing photochromic system based on an intraprotein intermolecular charge transfer (CT) complex between a flavin cofactor and a substrate-analogue inhibitor MXA (methylthioacetate or methylselenoacetate; X = S, Se) within monomeric sarc...

Systemic anticancer therapy for refractory malignant bowel obstruction in advanced cancer patients: a retrospective cohort study

Objectives Malignant bowel obstruction (MBO) is a common but severe complication of advanced cancer. The role of systemic anticancer therapy in patients with inoperable MBO remains poorly defined. This study aimed to assess the efficacy of systemic anticancer therapy in this sett...

European joint programme HBM4EU - Bridging science and policy: experiences and lessons learned from the key partners in the scientific steering of the initiative

The European Joint Programme HBM4EU was established to address politically relevant questions on chemical risks to public health through a targeted human biomonitoring research programme. Running from 2017 to 2022, it was co-financed by the EU's Horizon 2020 Research and Innovati...

Neutralization titers reveal the structure of polyclonal antibody responses

The composition of a polyclonal antibody response is hard to measure experimentally but contains vital information about the robustness of immunity. Here, we argue that the statistics of neutralization titers alone can be used to make quantitative predictions about the compositio...

Targeting the Complement C1 Proteases Using Camelid-Derived Single Domain Antibodies: Production, Characterization and Possible Application for Tissue/Fluid Analysis

Background. The complement C1r and C1s proteases initiate the classical complement pathway within the C1 complex, but emerging evidence points to additional roles in tissues, including cell-intrinsic functions linked to cancer and connective tissue disorders. Few tools are availa...

Universal random matrix behavior of a Fermionic quantum gas

Since its initial use by Wigner in describing heavy atom spectra, random matrix theory (RMT) has found applications and revealed universal laws in diverse physical contexts, from quantum field theory to disordered systems and wireless communications. A particularly compelling app...

Platelet GPVI drives fibrotic lung remodeling

Platelets are a major reservoir of bioactive mediators, including growth factors such as transforming growth factor β1 (TGF-β1), that regulate vascular repair and tissue remodeling. Beyond these classical functions, platelets also participate in inflammatory hemostasis through ac...

Comprehensive profiling of brain dynamics during anesthesia across phylogeny

Abstract The behavioral effects of anesthetics are highly conserved across species, hinting at shared and fundamental underlying mechanisms. Here we compile a dataset of multiscale neural activity during wakefulness and anesthesia, encompassing human, macaque, marmoset, mouse, ze...

Soft-Templated Carbon Models Elucidate the Anomalous Increase of Capacitance in Nanopores

Abstract Supercapacitors are electrochemical energy-storage devices distinguished by rapid charge–discharge and high power density. The observation of anomalously enhanced capacitance in nanoporous carbons challenged classical descriptions of double-layer charging and stimulated...

Deidentified data and analysis code for "LLM-assisted assessment item writing in medical education: a randomized pilot trial

This repository contains analysis code underlying the psychometric analyses of a randomized pilot study comparing LLM-assisted and conventional medical assessment item writing. It includes item-level psychometric outcomes, faculty-level aggregated outcomes used for exact permutat...