University of Wisconsin–Madison

Genome-wide prediction and association mapping of potato common scab with historical data

Abstract Common scab, caused by Streptomyces spp., is worldwide an important skin disease of potato, capable of significant reductions in marketable value. Resistant varieties developed through phenotypic selection have been the most effective strategy thus far. Previous studies...

Foliar metabolomes of woody plant communities across an elevational gradient on Mount Washington (New Hampshire, USA)

Abstract Background and Aims Plants produce myriad specialized metabolites that constitute the metabolome and mediate responses to abiotic and biotic factors. Elevational gradients, where environmental conditions change predictably over short distances, are natural laboratories f...

Large Magnetic Anisotropy in a Coupled Dinuclear FeII Field-Induced Single-Molecule Magnet

Abstract A series of [Me2indM(μ-Cl)(THF)]2 (M = Mn, Fe, Zn) dimers utilizing a novel bulky indoline ligand (Me2indH = 5-methoxy-2,2-dimethyl-3,3-diphenyl-7-diphenylmethylindoline) were synthesized and magnetically characterized. Analysis of the single crystal structure reveals th...

Cryostress in Frozen Soil. I: Concept, Definition, and Validation

Abstract The concept of cryostress in soil is conceptualized, defined, and validated. Force and water potential equilibrium principles at the scale of a soil–water representative elementary volume (REV) are employed to distinguish three types of forces: (1) skeleton forces transm...

History of instruments and technology in the clinical neurosciences: 2. Selected historical sources

Sources of information on the history of instruments and technology in the clinical neurosciences, particularly before 1900, are unfortunately arcane and fragmented. Therefore, a description of some of the resources available is provided to assist historians who wish to pursue st...

From Ionic Agitation to Precision Neuroablation: A Bioengineering Perspective on the Mechanisms, Modalities, and Clinical Applications of Radiofrequency Technology in Pain Management

Radiofrequency ablation (RFA) is a foundational interventional technology in pain management. Despite the diversity of available systems, conventional thermal, internally cooled, bipolar, and pulsed radiofrequency (PRF) all share one biophysical mechanism: high-frequency alternat...

Single-cell atlas of transcriptomic vulnerability across brain disorders

Abstract Neurodegenerative and neuropsychiatric diseases impose a considerable societal and public health burden. However, our understanding of the molecular mechanisms underlying these highly complex conditions remains limited 1,2 . Here, to gain deeper insights into the aetiolo...

Personalized single-cell transcriptomics reveals molecular diversity in Alzheimer’s disease

Alzheimer’s disease (AD) is highly heterogeneous and driven by diverse molecular and cellular mechanisms. Functional genomics investigates these mechanisms from genetic variants to gene expression and regulation. We performed personalized functional genomics analysis on populatio...

AI-based characterization of Alzheimer’s disease phenotypes from population-scale single-cell data

The complexity of Alzheimer’s disease (AD) manifests in diverse clinical phenotypes, including cognitive impairment and neuropsychiatric symptoms. However, the etiology of these phenotypes remains elusive. To address this, the PsychAD project generated a population-level single-n...

Cost analysis of venous stent reconstruction in the treatment of chronic lower extremity venous occlusive disease

As healthcare costs approach 20% of the United States’ gross domestic product, accurate healthcare cost accounting has become increasingly important [ 1 ]. Increases in the direct cost of hospital-based care have been predominant drivers of overall healthcare spending [ 1 , 2 , 3...

Specimen-level phylogenetic analysis and taxonomic revision of North American metoposaurids: a case for monospecific genera in vertebrate paleontology

The Metoposauridae were a widespread family of aquatic Late Triassic temnospondyl amphibians known from numerous localities in non-marine strata of the Northern Hemisphere, India, and Madagascar. Recent descriptions of intraspecific variation in skulls from hyper accumulations su...

Signatures of incoherent mixing pathways in action-detected spectroscopies

Incoherent population mixing creates a large background in ultrafast, action-detected pump-probe and 2D spectroscopies. This background often obscures the desired coherent responses and leads to incorrect assignment of spectral features. In a previous study, we postulated three c...

Single-nucleus transcriptome-wide association study of human brain disorders

Abstract Common brain disorders impose a substantial health burden, but localizing their genetic risk in the brain remains challenging 1 . Although genome-wide association studies have identified numerous loci associated with neuropsychiatric and neurodegenerative disorders, many...

Achieving Large Uniaxial and Homogeneous Strain in Two‐Dimensional Materials

ABSTRACT Strain is a powerful tool for tuning the electronic, magnetic, and topological properties of 2D materials ‐ particularly at high values of strain () where many electronic, magnetic, and structural transitions are predicted. However, most approaches to straining 2D materi...

Single-nucleus atlas of cell-type specific genetic regulation in the human brain

Abstract Genetic risk variants for common diseases are predominantly located in non-coding regulatory regions and modulate gene expression. Although bulk tissue studies have elucidated shared mechanisms of regulatory and disease-associated genetics, the cellular specificity of th...

Lifespan single-cell transcriptomic atlas of the human prefrontal cortex

The human brain undergoes profound changes from early development through late adulthood, shaping cognition, behaviour and vulnerability to disease1,2. Understanding how these changes are organized within specific brain regions and cell types is essential for interpreting normal...

A strategic framework for pathology faculty onboarding

Effective oversight of talent acquisition, integration, management, and retention in an academic pathology department is critical to sustaining its tripartite mission of clinical service, research, and education. Despite substantial focus on these areas, the crucial initial trans...

Decongested 2D IR Spectra Reveal N-Terminal Helices in Amyloid Oligomers Associated with Type 2 Diabetes

Abstract Oligomeric peptides are implicated in amyloidosis, yet only a few atomic structures of amyloid oligomers have been identified. Recently, we reported an atomic structural model of human islet amylin polypeptide (hIAPP) oligomer [Shivani, S. T.; et al.Proc. Natl. Acad. Sci...

Blood proteomics of menopause map to brain aging and dementia risk

Abstract Menopause is a hallmark process in biological aging that has been implicated in later neurodegenerative risk, but the pathways underlying this connection remain unclear. Here we used blood proteomics data from several cohorts to identify biological changes associated wit...

Electrochemical Platform for Automated Design-of-Experiment Optimization of Ni-Catalyzed Cross-Electrophile Coupling Reactions

Abstract Electrosynthetic organic reactions have advanced significantly in recent years, but their adoption for large-scale applications remains limited. Here, we report an automated experimental platform designed to facilitate translation of small-scale chemical and electrochemi...