University of Wisconsin–Madison

From Choose and Hope to Evidence and Impact: Rethinking School-Based Behavioral Health Decisions

A challenge in school-based behavioral health is how evidence-based practices are selected and implemented. Decision-making within schools often prioritizes feasibility instead of research evidence. The purpose of this study was to examine the experiences of school decision-maker...

Structure-Based Insights into the Molecular Mechanisms of LuxR-Type Quorum Sensing Receptors

Quorum sensing (QS) enables bacteria to coordinate collective behaviors in response to population density. LuxI/R QS systems, common among gram-negative bacteria, consist of a LuxI-type synthase that produces an N- acyl L -homoserine lactone (AHL) signaling molecule and a LuxR-ty...

Lymphatic endothelial cells regulate neutrophil phenotypes and function in a microphysiological model of infection

Early skin inflammation requires coordinated immune regulation, with neutrophils acting as first-line responders. While the blood vasculature and its role in neutrophil recruitment during infection has been extensively studied, the lymphatic system remains comparatively understud...

Does Political Decoupling Through Fair Market Privatization Improve Managerial and Political Outcomes? Insights From Water Utility Sales

ABSTRACT Many U.S. municipalities face environmental service delivery challenges, including aging infrastructure and rising debt. In response, several states have adopted Fair Market Value (FMV) legislation, which aims to incentivize private firms to acquire and invest in municip...

The Weight of the Number: Perceptions and Practices Surrounding Expected Body Weight Disclosure in Eating Disorder Treatment

ABSTRACT Objective Expected body weight (EBW) determination is common in eating disorder (ED) treatment, yet no evidence‐based guidelines exist for how to discuss EBWs with patients. Clinicians have previously conceptualized these discussions as therapeutic exposures targeting fe...

A network approach with motion sequencing reveals hidden patterns of repetitive behavior in a pre-clinical model of epilepsy

Epilepsy is the 4th most prevalent neurological condition with 50 million cases worldwide. Patients with epilepsy bare a disproportionate burden of cognitive decline and psychiatric disorders which remain poorly understood and go unaddressed by current anti-epileptic treatments....

Predictive value of preoperative esophagram in postoperative outcomes after antireflux surgery

Abstract Background Gastroesophageal reflux disease (GERD) significantly impairs quality of life. Antireflux surgery (ARS) improves symptoms when medical therapy fails, but postoperative recurrence and dysphagia remain concerns, emphasizing the need for improved preoperative risk...