University of Milan

Digital solutions for tackling mental health in cancer patients and their families: The ALTHEA project

Despite advances in cancer treatment, the growing global cancer burden underscores the need for comprehensive and supportive care to address the needs of patients and their families. However, access to psycho-oncological support remains often limited across healthcare systems. Th...

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

The Composite Spectrum of QSO Absorption Line Systems in DESI DR2

Abstract We present details regarding a composite spectrum of quasar (QSO) absorption line systems. In this composite spectrum, we identify more than 70 absorption lines and observe oxygen and hydrogen emission features at a higher signal-to-noise ratio than any previous study. A...

Conservative Management of Pediatric Mandibular Condylar Fractures: A Systematic Review

ABSTRACT Mandibular condylar fractures are common mandibular injuries in children. Conservative treatment is generally favored because of the remodeling capacity of the growing condyle, although rehabilitation protocols and the criteria for operative treatment remain variable. Th...

A scalable Zebrafish Platform for genetic validation and functional discovery of stage-specific breast cancer metastasis regulators

Metastatic disease accounts for over 90% of breast cancer-related deaths, yet scalable in vivo models for functional analysis of distinct metastatic steps remain limited. Here we show that an optimized zebrafish xenotransplantation platform enables quantitative, stage-resolved an...

Use of Tamoxifen Derivatives in Combination with Colistin against Colistin-Resistant Acinetobacter baumannii

Abstract Drug repurposing has led to the identification of tamoxifen, a well-known chemotherapy drug, as a compound with relevant antibacterial properties. In this field, the development of new tamoxifen derivatives with antimicrobial activity, particularly against colistin-resis...

HIV breakthrough infection after 6 years of daily TDF/FTC oral PrEP with objectively documented optimal adherence

Oral Pre-Exposure Prophylaxis (PrEP) is highly effective for HIV prevention when adherence is optimal, with rare HIV breakthrough infections usually happening within 1–2 years since PrEP start. After 6 years of daily PrEP, routine HIV testing identified seroconversion in a 46-yea...

On the Lavrentiev Gap for Manifold-Valued Maps

Abstract We characterize necessary and sufficient conditions ensuring approximation by smooth maps in the Sobolev space $$W^{1,\varphi }$$ W 1 , φ between suitable compact manifolds, where the prototypical example of Young function $$\varphi $$ φ is the double-phase integrand.

I casi studio per testare utilità e validità dell'Atlante Aria Salute: definizione del quadro concettuale.

OBJECTIVES: to describe the process of selecting and applying a shared conceptual model for the analysis of case studies designed to test the usefulness and validity of the Air and Health Atlas in supporting decision-making, in its current version and in its potential future deve...

Everything you always wanted to know about sleep, but you were afraid to ask: expert concise guide and recommendations on assessing sleep-wake disturbances within a psychiatric context in contemporary times

OBJECTIVE: While disrupted sleep has long been linked to mental disorders there has been a notable decrease in interest and sleep-wake disorders have received low priority in psychiatric care. The aim of the paper was to present a concise guide for evaluating common sleep-wake di...

21-Gene recurrence score assay in pN2-3 Early-Stage breast cancer: a national cancer database study

BACKGROUND: The clinical utility of the 21-gene recurrence score (RS) for guiding adjuvant chemotherapy in patients with pN2-3 early-stage breast cancer (eBC) has not been evaluated in prospective trials. This study aims to assess adjuvant chemotherapy benefit in patients with pN...

Delayed Arm Retraction Controls the Nonlinear Oscillatory Response of Long-Chain-Branched Polymer Melts

Abstract Long-chain branching profoundly modifies the nonlinear oscillatory response of entangled polymer melts by introducing arm-retraction pathways absent in linear polymers. We present a molecular tube theory that explains the characteristic maximum of the Nonlinearity Index...

A common germline 3′ UTR variant controls DDIT4 translation efficiency and stress responses in cancer cells

Systematic strategies for identifying and classifying variants that directly modulate ribosome engagement are lacking. Here, we develop and extensively validate a pipeline to identify translation-associated single-nucleotide polymorphisms (tranSNPs) by integrating analysis of tot...

Computational identification and experimental validation of early glycinergic impairments in spinal muscular atrophy

Spinal Muscular Atrophy (SMA) is a progressive neurodegenerative disorder characterized by lower motor neuron (MN) loss, due to mutations or deletions in the Survival Motor Neuron 1 ( SMN1 ) gene. Increasing evidence implies mitochondrial dysfunctions in SMA, suggesting these org...

Effects of Oral Iron and Commercial Colostrum Supplementation on Clinical Health and Haematological Parameters in Neonatal Chianina Beef Calves: A Pilot Study

The neonatal period is a critical stage for calf health and development, and nutritional interventions have been proposed to support neonatal adaptation and reduce disease risk. However, evidence regarding their effectiveness in extensively reared beef breeds remains limited. Thi...

VEGF pathway signalling across pulmonary neuroendocrine tumours: associations with histological subtypes in a multicentre study

Abstract The current classification of pulmonary neuroendocrine neoplasms (NENs) is primarily based on histomorphological criteria, which do not fully capture their underlying biological heterogeneity. This limitation is particularly evident among pulmonary carcinoids, a subgroup...

Performance evaluation of a preclinical SPECT system and optimization of imaging protocols for 177Lu-labelled radiopharmaceuticals

This study investigates the performance of the γ-CUBE preclinical SPECT scanner to optimize acquisition and reconstruction protocols for theranostic preclinical studies, and to determine the minimum administered activity of a novel 177 Lu-labelled peptide in a mouse cancer model...

Toward personalized shared decision-making: a pilot study on an individualized patient decision aid

Decision aids are tools that can reduce decisional conflict and enhance patient satisfaction in the decision-making process. However, tool heterogeneity and clinical barriers, such as physician time constraints, hinder their implementation. This study introduces an individualized...

The Role of Targeted Rehabilitation in Enhancing Recovery After Total Hip Arthroplasty with Anterior Minimally Invasive Surgery Approach: A Retrospective Pilot Study

Background: Hip osteoarthritis is a highly prevalent degenerative condition and a leading indication for total hip arthroplasty (THA). As anterior approaches have gained popularity, optimizing postoperative rehabilitation according to the muscles involved in recovery has become i...

Intratendinous Porcine‐Derived Type I Collagen Injections Result in Clinical and Radiographic Improvement of Rotator Cuff Tendinopathy 1 Year After Treatment

Purpose To evaluate the clinical and radiological effectiveness of porcine‐derived type I collagen injections in patients with symptomatic rotator cuff tendinopathy. Methods In this monocentric pilot study conducted between 2022 and 2025, adults with clinically and radiologically...