University of Milan

Benchmarking generative AI tools for literature retrieval and summarization in genomic variant interpretation

Abstract Background Generative AI is increasingly used to extract structured information across domains, but its reliability in academic and clinical research, where precision and accuracy are essential, remains largely unexplored. This study evaluates the ability of Large Langua...

Snow microinvertebrates from lowlands, high mountains and the Arctic—implications for conservation efforts

Abstract The protection of cryospheric ecosystems and their biota cannot be properly defined without a detailed species inventory. Snow microinvertebrates are crucial for estimating cryophilic biodiversity, yet they are poorly described at broader spatial scales. To fill this kno...

Single‐stage regenerative approach for persistent RT3 gingival recession following orthodontic improvement of tooth position

Abstract Background Management of gingival recession type 3 (RT3) defects remains a clinical challenge due to interproximal attachment loss and soft tissue deficiency. This case report describes a regenerative strategy for a malpositioned anterior tooth presenting with severe rec...

Misperceptions of charismatic species' conservation status: Zoo visits and virtual exposure shape perceptions of extinction risk

Abstract Biodiversity loss is accelerating globally, yet species are not equally affected, and public perceptions of extinction risk often diverge from scientific assessments. Understanding what shapes public perceptions is critical for effective conservation communication, parti...

Effects of immersive training on sports perceptual-cognitive skills: A systematic literature review

Immersive training using virtual reality (VR), 360° video, and CAVE environments shows potential for enhancing perceptual-cognitive skills in sports; however, evidence remains limited and methodologies heterogeneous. This systematic review synthesised quantitative controlled inte...

A systematic review of divine forgiveness self-report measures

Abstract Background Divine forgiveness (DF) can be defined as the perception of being absolved from sin by a Higher Power. Psychological research is increasingly recognizing DF as a relevant construct with implications for well-being, coping, and spirituality. Despite this growin...

Cell senescence emerges as a hallmark and therapeutic target of chronic intracellular infection

<title>Abstract</title> Intracellular pathogens are ideal candidates for modelling the pathophysiology of chronic infection, as they hide within host cells and avoid conventional immune clearance through a controlled reshaping of cellular fate. This study unveils how the emerging...

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

BACKGROUND: This first part of the S2k guidelines is an update of the 2015 S1 European guidelines based on the structured assessment of clinically relevant topics by the panel of experts. It is complemented by Part 2, which deals with treatments. OBJECTIVES: These guidelines aim...

Real‐world outcomes of venetoclax plus hypomethylating agents in unfit acute myeloid leukaemia: Results of the GIMEMA AML2320 trial

Summary Venetoclax (VEN) plus hypomethylating agents (HMAs) represents the standard of care for newly diagnosed acute myeloid leukaemia (AML) patients unfit for intensive chemotherapy, but prospective real‐world observational data outside randomized clinical trials remain limited...

Spheroid cultures reveal cancer stem cell enrichment and distinct chemotherapeutic response in triple-negative breast cancer

Three-dimensional (3D) cancer spheroids mimic key morphological and biological features of solid tumors, providing a valuable model for evaluating drug responses. Here, we investigated whether intrinsic cancer stem cell composition and tumor subtype determine spheroid formation c...

Self-Signaling and the Anonymity Norm: A Quasi-Natural Field Experiment on Identity-Based Altruism

Abstract Contrary to standard models of indirect reciprocity, Muslim donors prefer anonymous donations and out-group causes rather than public and in-group ones. This study investigates the Western context. It examines whether the self-signaling behavior of Western Muslim donors...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

Sociality and nesting strategy account for non-random associations between bees and their parasitic dipterans

Abstract Bees (Apoidea: Anthophila) are recorded as common hosts of a diverse array of parasitic Diptera species, but information is widely scattered across the literature, limiting our knowledge of global bee-dipteran association patterns. Here, we retrieved published informatio...

The value of mortality data to advance learning and decision-making dynamics in Mozambique’s health system

Abstract Introduction There is a lack of evidence on whether and how health systems stakeholders in Mozambique learn from routine health data. Despite the recurring claim by the stakeholders themselves that data in general should be the centre of informed public health policy, it...

The memory metaphors held by ordinary people: an exploratory study

Metaphors are widely used by researchers to communicate ideas in cognitive psychology. This is the first study to systematically explore the naïve psychology of human memory metaphors. We attained this goal by surveying a large sample of the adult population resident in Northern...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...

A Modified Delphi consensus on early management of combined cardiovascular risk factors in adult patients with type 2 diabetes in Italy

BACKGROUND: Type 2 diabetes (T2D) is a complex chronic disease often associated with other metabolic conditions that increase the risk of cardiovascular (CV) disease and early mortality. Hence, early, integrated management of T2D may prevent long-term CV complications. METHODS: T...

Polynomial Prethermal Lifetimes in Non Smoothly Driven Quantum Systems

Abstract We study the dynamics of a quantum many-body lattice system with a local Hamiltonian subjected to a quasi-periodic driving with finite regularity. For sufficiently large driving frequencies, we prove that the system remains in a prethermal state for times growing polynom...

Revisiting the productide (Productidina, Strophalosiidina) brachiopod fauna from upper Visean (Mississippian) reefs in Belgium and UK: systematics, palaeoecology and evolutionary implications

The Asbian (upper Visean, Mississippian) reefs of North Yorkshire, Derbyshire (UK) and Visé (Belgium) host rich brachiopod faunas studied since the 19th century. This paper revises the productide brachiopods, which dominate the benthic assemblages in both abundance and diversity....

When the Law Changes Therapy: Interrupted Time-Series Analysis of the Regulatory Impact on Intravenous Analgesic Consumption in 2 Italian Orthopaedic Hospitals (2021-2024)

Objectives: Tramadol is a centrally acting weak opioid widely used for moderate postoperative pain in orthopaedic surgery, so its regulatory status is directly relevant to hospital pharmacists. In November 2022 the Italian Ministry of Health reclassified tramadol as a controlled...