University of Edinburgh

The playful entanglements of very young children’s intergenerational video calls across cultures and languages: More-than-human perspectives

The United Kingdom is home to a culturally and linguistically diverse population of young children living in families where digital technologies offer unprecedented opportunities to develop multiliteracies across languages. Many babies and toddlers born into multilingual families...

The politics of restricted inclusion: a longitudinal policy analysis of healthcare access for people living as undocumented migrants in Sweden

This study examines how healthcare access for people living as undocumented migrants has been constituted, contested, and reconfigured in Sweden from the early 1990s to the mid 2020s, challenging institutionalist claims that universalist welfare systems reliably generate solidari...

Scalable Fitting Methods for Multivariate Gaussian Additive Models with Covariate-dependent Covariance Matrices

We propose efficient computational methods to fit multivariate Gaussian additive models, where the mean vector and the covariance matrix are allowed to vary with covariates, in an empirical Bayes framework. To guarantee the positive-definiteness of the covariance matrix, we model...

Developing the productive emotion vocabulary test (PEVT) for adult speakers of English as an additional language

Abstract Emotion vocabulary (EV) is integral to language proficiency, yet it is rarely assessed, and existing tools are largely decontextualised and unvalidated for adult users of English as an additional language (Lx). We introduce the Productive Emotion Vocabulary Test (PEVT),...

Face covering adherence is positively associated with better mental health and wellbeing: a longitudinal analysis of the CovidLife surveys

Background Face masks or coverings are effective at reducing airborne infection rates, yet pandemic mitigation measures, including wearing face coverings, have been suggested to contribute to reductions in quality of life and poorer mental health. Complaints of inconvenience, dis...

From a rock to a hard place: how carbonate rocks are born and made

James Hutton recognised that some components of sedimentary rocks have a biological and marine origin as they contain ‘ solid parts ’ (mainly calcite) of past sea life, and so might offer an archive of Earth's history. Much current research effort on carbonate rocks, those that a...

Christ the Jailer: Paul’s Carceral Theology

Abstract The apostle Paul has gone down in history as a ‘prisoner of Christ’ (Phlm 1). However, the ramifications of this statement remain curiously under-explored. This article follows the logical implication of this phrase that if Paul is a prisoner, Christ is a jailer. Here as...

A canonical role of SMAD4 in safeguarding 3D genome architecture to suppress lung tumorigenesis

Dysregulation of three-dimensional (3D) genome architecture is a hallmark of cancer, yet the mechanisms by which its disruption drives tumorigenesis remain incompletely understood. Here, we demonstrated that SMAD4 regulated 3D genome organization through its canonical transcripti...

Deciphering the genomic signatures of climate vulnerability across 77 sheep breeds

Abstract Among domesticated species, sheep ( Ovis aries ) have achieved a wide geographic distribution due to their mobility, rusticity and ability to adapt to diverse environments and climatic conditions. Here, we characterise the genome-wide diversity of >1,000 sheep representi...

Unmet needs in functional neurological disorder related to digital healthcare

Functional neurological disorder (FND) is a common yet historically neglected condition that presents major unmet needs across diagnosis, treatment and health service delivery. This article examines how digital healthcare could address gaps in several areas: (i) using large bioba...

Promotion of long-term health in early life

Noncommunicable chronic diseases (NCDs) are on the rise in high-income countries, leading to substantial morbidity and mortality and contributing to increased resource demands and healthcare costs. Early-life exposures can initiate trajectories that culminate in NCDs later in lif...

The Many Faces of the Parasite

The introduction to this special issue describes the ‘parasite’ as a concept through which to understand the problems and possibilities of cohabitation, with its attendant strategies of shelter and expulsion, its affects of gratitude and resentment. Building on the work of Michel...

Hybrid authentication protocols for advanced quantum networks

Abstract Authentication is a fundamental building block of secure quantum networks, essential for quantum cryptographic protocols and often debated as a key limitation of quantum key distribution (QKD) in security standards. Most quantum-safe authentication schemes rely on small...

Prompting Large Language Models with Partial Knowledge for Answering Questions with Unseen Entities

Retrieval-Augmented Generation (RAG) systems are often constrained by the “relevance myopia”, primarily focusing on fully relevant external information to supply missing or outdated facts while overlooking the potential of partially relevant knowledge to activate the internal kno...

MSRA-CCL: Multi-Source Reliability-Aware Aggregation and Cross-Domain Consistency Learning for Weakly Supervised Sentiment Classification

Sentiment classification often relies on costly in-domain annotations, while weak-supervision sources provide low-cost but inconsistent labels. We propose Multi-Source Reliability-Aware Aggregation and Cross-domain Consistency Learning (MSRA-CCL) for weakly supervised sentiment c...

Radiological pattern of hip osteoarthritis is associated with one-year patient-reported outcomes but not long-term mortality or revision after total hip arthroplasty

Aims: This study aimed to determine the effect of the radiological patterns of hip osteoarthritis (OA) on patient-reported outcome measures (PROMs) at one year following total hip arthroplasty (THA) and their impact on long-term mortality and survivorship. Methods: This retrospec...

Splenic regulation of systemic platelet activation state

Platelets are essential to prevent blood loss and to orchestrate inflammation. Thrombotic complications of vascular disease and hyperresponsive platelets are associated with adverse outcomes, yet physiological mechanisms counteracting systemic platelet activation are poorly defin...

A systematic interactome of Saccharomyces cerevisiae SET1C expands its functional landscape and identifies candidate regulatory connections

Set1 is the catalytic subunit of SET1C or COMPASS, which methylates histone H3K4 and serves as a scaffold for the association of seven tightly bound polypeptides. We have employed yeast two-hybrid screenings to determine the interactome of Set1 and each subunit, providing a uniqu...

Between expectations and outcomes: Technology adopters' narratives and technology discourse dynamics

Expectations propel the evolution of emerging technologies, yet existing research generally assumes that expectations are gradually displaced by concrete outcomes as technologies mature and become widely accepted. We revisit this assumption by examining how technology adopters' t...

When is prosecution in the public interest?

Abstract Prosecutors in England and Wales may start or continue a prosecution only if to do so is in the public interest. No general account has previously been given, however, of what the public interest consists in. This paper aims to provide such an account, drawing on a study...