University of Edinburgh

Cell-intrinsic steroidogenesis regulates mast cell function

Steroid hormones are well-known regulators of mast cell function, but whether mast cells themselves produce steroids de novo and influences their effector function has remained unknown. Here, we show that mast cells constitutively express the steroidogenic enzyme cytochrome P450...

The Challenges of Hyperparameter Tuning for Accurate Causal Effect Estimation

Abstract ML is playing an increasingly crucial role in estimating causal effects of treatments on outcomes from observational data. Many ML methods (‘causal estimators’) have been proposed for this task. All of these methods, as with any ML approach, require extensive hyperparame...

Intimacy Beyond the Human

How can human carnal needs be fulfilled in a technological environment in which the digital body replaces the tangible body as a sexual provider? This question is explored through the imagination of science fiction cinema. Spike Jonze’s Her (2013) presents an affective narrative...

Cosmological Constraints from Full-scale Clustering and Galaxy–Galaxy Lensing with DESI DR1

Abstract We present constraints on cosmic structure growth from the analysis of galaxy clustering and galaxy–galaxy lensing with galaxies from the Dark Energy Spectroscopic Instrument (DESI) Data Release 1. Our analysis includes four samples drawn from the Bright Galaxy Survey (B...

Belonging in fragments: an autoethnography of a Chinese international student in Edinburgh

Purpose This article explores belonging as a fragile and shifting process in the everyday life of a Chinese international postgraduate student in Edinburgh. Design/methodology/approach Using autoethnography, the article draws on retrospective memory, earlier autobiographical writ...

Destructive authority over online-game assets: Conditional access and platform-mediated harm

Online-game losses span contract, tort, consumer-law and computer-access doctrines across distinct legal relationships. This article asks how law should characterise and remedy destructive interference with virtual assets when technical access, contractual control or system-enabl...

Astrophysical Parameters of 5056 Open Star Clusters from Bayesian Nested Sampling with PARSEC Isochrones

Abstract We present a homogeneous catalogue of ages, metallicities, distances, and reddenings for 5 056 open clusters in the Unified Cluster Catalogue (UCC), derived uniformly from Gaia Data Release 3 (DR3) colour–magnitude diagrams via Bayesian nested sampling with PARSEC isochr...

The Evolution of Low-ionization Electron Densities in Galaxies across Cosmic Epochs

Abstract We investigate the low-ionization electron density in the interstellar medium (ISM) of galaxies across 0 < z < 8, derived with the [O ii ] λλ 3727, 3730 and [S ii ] λλ 6718, 6733 doublets, using both deep JWST/NIRCam/grism and NIRSpec/MSA spectroscopy. Along with ancilla...

A 15-year evaluation of two total knee arthroplasty designs

Aims: To compare 15-year patient-reported outcomes measure (PROMs), pain characteristics, implant survivorship, and radiological findings between two total knee arthroplasty (TKA) systems to determine whether modern implant design influenced outcomes. Methods: A minimum 15-year f...

Notch signalling governs human enteric nervous system progenitor dynamics

The enteric nervous system (ENS) is the main branch of the peripheral nervous system that innervates the gastrointestinal tract controlling vital functions. It arises during embryogenesis via migration, proliferation and differentiation of neural crest-derived ENS progenitors. Pe...

Learning from social assessments of innovative non-sewered sanitation in eThekwini

As non-sewered sanitation (NSS) is being designed, developed, tested and rolled out, there is widespread support for the integration of social science. Yet what, precisely, social science can and should do remains much less clear. This paper explains the specific approach of soci...

Product‐Reshaped Gas‐Phase Hydrodynamics Govern CO 2 Electrolysis in Gas Diffusion Electrodes

ABSTRACT High‐rate electrolysis is commonly assessed using current density, single‐pass conversion and Faradaic efficiency, but these global metrics do not indicate whether the local reaction environment required for selective multicarbon formation is preserved during scale‐up. U...

Treatment restrictions after acute stroke across nine European countries and their association with 90-day mortality: a post hoc analysis of the PRECIOUS randomised controlled trial

Background In patients with acute stroke, early withholding or withdrawal of life-sustaining therapies is associated with an increased risk of death. We used practice variation across nine European countries to assess whether this relation may be causal. Methods We performed a po...

Navigational affordances emerge stably with brief stimulus exposure despite changes in scene content

Everyday life requires successful navigation often through complex and dynamic environments. The ability to identify efficient and safe routes of egress through scenes relies on perception of the navigational affordances of scenes. Recent behavioral work identified that navigatio...

Gene-rich fungus gnat germline-restricted chromosomes are largely transcriptionally quiescent

Germline-restricted chromosomes (GRCs) constitute a unique class of chromosomes confined to germ cells. Arising in multiple evolutionarily distant lineages, GRCs have been identified in three insect families (non-biting midges, gall midges, and fungus gnats), each within the orde...

A fast and frugal Gaussian boson sampling emulator

Classical algorithms have successfully reproduced expectation values of observables for certain quantum circuits using off-the-shelf computing resources; however, matching the performance of the most advanced quantum devices on sampling problems typically incurs extreme memory an...

Blood companions: the Holocene record of ectoparasites

Abstract The Holocene fossil record of human and animal ectoparasites comprises specimens from sites worldwide, providing a unique perspective on human mobility, domestication and zoonotic disease. Lice, fleas, bedbugs, louse flies, ticks and mites have been recovered from sites...

Prevention is better than cure

Wider access to clean water and sanitation is needed in the battle to combat bacterial diseases.

Summertime ozone sensitivity to temperature in China: observational evidence and mechanistic attribution in urban and rural areas in the Yangtze River Delta region

Abstract. As climate change increases frequency and intensity of hot extremes, understanding how elevated temperatures influence surface ozone (O3) across different chemical regimes is critical. We combine observations from summer 2022 in the Yangtze River Delta (YRD) with target...

‘Think What They Have Meant to Me’: The War Poems of Roland Leighton

Scholarly discussion of Roland Leighton has previously been limited to his relationship to Vera Brittain and his role in her life as depicted in her memoir Testament of Youth. This article examines three of Leighton’s poems in the context of First World War poetry and thereby all...