University of Edinburgh

The moonlighting functions of SEC13 in nonsense-mediated mRNA decay and the regulation of ER stress

ABSTRACT The nonsense-mediated decay pathway (NMD) is an RNA quality control mechanism that regulates the stability of target RNAs. We previously identified the ER-localized SEC13 protein as a novel NMD factor in C. elegans and in HeLa cells; raising the possibility that it could...

The burden of suicide by paraquat poisoning in Taiwan (1987–2017): trends, geographic variations, and demographic characteristics

Pesticide self-poisoning accounts for 14%–20% of global suicides. Paraquat, a highly lethal pesticide, is involved in a considerable number of suicides in some countries. This study investigated the burden, trends, geographic variations, and demographic characteristics of pestici...

Early recognition of limb necrotizing fasciitis and surgery within six hours is associated with a lower mortality risk and improved patient-reported outcomes

Aims Necrotizing fasciitis (NF) is a rapidly progressive surgical emergency. The effects of time from hospital presentation to theatre on short- and long-term outcomes, as well as specific modifiable aspects of the care pathway that would enable early surgery, remain poorly defin...

Necrotizing fasciitis

Necrotizing fasciitis is a rapidly progressive, life-threatening infection originating in a fascial plane which requires emergency surgery. Although uncommon, with an incidence of 0.63 per 100,000 per year, it affects the limbs in 40% of cases and carries a 22% 30-day mortality r...

markella-moraitou/Roman_oral_microbiomes: Accepted version

No description provided.

Development and validation of the personal recovery scale (ReConnect) for mental health in Ethiopia

Background: Socio-cultural context is crucial for conceptualising personal recovery in mental health, but existing measures are from Western, high-income countries. Aim: To develop and validate a mental health personal recovery measure for people with mental health conditions in...

Kids These Days! A Cross-Temporal Meta-Analysis of Changes in Emotional and Behavioral Problems of Population-Based Samples Over the Past Decades

Abstract There is a general belief that mental health problems are increasing in younger generations, though little objective comparisons exist. The current meta-analysis examines changes in subclinical mean-level overall symptom burden and shifts in specific domains among popula...

Accelerometers improve detection of movement related artifact in bedside ICU data

Abstract Routinely collected real time data from ICU bedside monitors is a valuable source of information which can assist the clinical team caring for a patient. This data almost always contains artifacts caused by clinical staff attending to the patient throughout the day, e.g....

Rendering for Torture: Enacting Secrecy Through Fabrication and Division

This paper explores how specific provisions of the NATO cooperation framework, as well as those governing international civil aviation, were strategically used by the CIA to maintain the secrecy surrounding the Rendition, Detention and Interrogation (RDI) programme during the ear...

GlycanAge dynamics and their relationship to SCORE2 risk change over six months: a secondary analysis of a randomized controlled trial

Abstract Chronological age dominates cardiovascular (CVD) risk prediction, but glycan-based measures may better reflect biological ageing. In this secondary analysis of a six-month randomized controlled trial in Slovenia, we examined whether IgG glycosylation–derived biological a...

Estimated glucose disposal rate and incident cardiovascular disease across ageing cohorts in China, England, and the United States: cross-national consistency and transportability

The estimated glucose disposal rate (eGDR), an insulin-resistance surrogate derived from routine clinical variables, has been associated with cardiovascular disease (CVD). We examined its association with incident CVD, cross-national transportability, and incremental discriminati...

Identification of cellular double-stranded RNAs in mammalian embryonic stem cells

Abstract Antiviral defence mechanisms are typically activated upon sensing virus-derived nucleic acids. During replication, viruses generate double-stranded RNA (dsRNA) intermediates that the innate immune system can sense, triggering several defence pathways. Conversely, mammali...

Simple birth-death-mutation models predict some—but not all—aspects of the experimental evolution of antibiotic resistance

Mathematical modelling of antibiotic resistance plays an important role in understanding the mechanisms of resistance emergence and spreading, testing the feasibility of new treatment protocols, and antimicrobial stewardship. However, many assumptions underlying some of the most...

Evaluating the Cost-Effectiveness of Interlinked Fire Alarm Systems in Scotland and England

Abstract This paper applies the J value framework to assess when interlinked domestic fire alarm systems would be cost effective in Scotland and England. Pre policy national statistics pool dwellings with no alarms, standalone alarms (the vast majority), and some interlinked syst...

90 Developing Patient-Focused Outcomes for Routine Clinical Care in Glioma: A Synthesis of Qualitative Evidence from the COMBaT Study

Abstract Introduction There is a critical need to identify and routinely measure the outcomes that matter most to people living with glioma. Care needs in this population are complex and variable, yet current clinical practice lacks consistent, systematic approaches to assessing...

Episodic super-Eddington accretion as a clue to Overmassive Black Holes in the early Universe

Abstract Early JWST observations are providing growing evidence for a ubiquitous population of accreting supermassive black holes (BHs) at high redshift, many of which appear overmassive compared to the empirically-derived local scaling relation between black hole mass and host g...

Recent strengthening of eastern Pacific ENSO in the last millennium paleorecord

The Pacific El Niño–Southern Oscillation (ENSO) generates climate extremes that endanger ecosystems, infrastructure, and human well-being worldwide. The response of this system to climate warming is poorly constrained, due both to data scarcity and uncertainties in climate models...

72 Primary care coding and psychotropic prescribing in young cancer survivors: mental health morbidity misclassification and implications for brain tumour survivorship

Abstract Introduction Survivors of childhood, teenage and young adult (CTYA) brain tumours experience higher rates of depression and anxiety than other CTYA cancer survivor groups. As secondary care data alone underestimate this burden, we evaluated whether integrating primary ca...

Why variant effect predictors and multiplexed assays agree and disagree

Abstract Computational variant effect predictors (VEPs) and multiplexed assays of variant effect (MAVEs) are two key tools for assessing the functional consequences of genetic variants. While their outputs are often concordant, there are also many differences. Here, we analyse mi...

Age-related shifts of dissolved hydrogen and its impact on rumen fermentation dynamics and microbial communities in goats (Capra hircus)

Abstract The rumen is a complex anaerobic fermentation ecosystem in which microbial communities undergo dynamic changes during host development, influencing fermentation efficiency, hydrogen utilization, and methane (CH₄) production. However, how rumen maturation reshapes hydroge...