University of Edinburgh

Solvent Selection and in Silico Process Design for the Development of Cost-Effective Yet Green Crystallization for Pregabalin Manufacturing

Abstract Developing crystallization processes for the production of pharmaceuticals that are both cost-effective and environmentally friendly is a highly complex challenge, since it is often the case that too many candidate systems exist for them to all be studied experimentally....

The DESI Y1 RR Lyrae Catalog. II. The Metallicity Dependency of Pulsational Properties, the Shape of the RR Lyrae Instability Strip, and Metal Rich RR Lyrae

Abstract RR Lyrae stars (RRLs) are valuable probes of both Milky Way assembly and stellar-evolution physics. Using a sample 6240 RRLs obtained in the first year of the Dark Energy Spectroscopic Instrument (DESI) survey, we investigate the metallicity of RRLs and its correlation w...

CEO Inherited Altruism, Firm Corporate Social Responsibility, and Shareholder Returns

Abstract We examine the impact of CEOs’ inherited altruistic inclination on firm corporate social responsibility (CSR) performance and shareholder returns. Specifically, we look at U.S. CEOs’ altruism as an inherited value of the CEOs’ ancestral cultural origin that shapes their...

Conserved hepatic RNA signatures across multiple cohorts reveal novel mechanistic clues for advanced fibrosis in human MASLD.

BACKGROUND: Fibrosis development in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) is a key indicator of disease progression and clinical outcome. Bulk and single-cell transcriptomics on human tissue have advanced understanding of fibrosis progress...

The DESI Y1 RR Lyrae Catalog. I. Empirical Modeling of the Cyclic Variation of Spectroscopic Properties and a Chemodynamical Analysis of the Outer Halo

Abstract We present the catalog of RR Lyrae stars (RRLs) observed in the first year of operations of the Dark Energy Spectroscopic Instrument (DESI) survey. This catalog contains 6240 RRLs out to ∼120 kpc from the Galactic center and over 12,000 individual epochs with homogeneous...

Optimizing multi‐trait selection for profitability in Illinois wheat using a factor analytic mixed model and an economic selection index

Abstract Economic selection indices can improve the efficiency of selection for multiple traits, but they are underutilized in plant breeding due to limited research on the economic values of traits and a lack of well‐documented case examples employing economic indices. This stud...

Rectifying market externalities via AI policymaking

Abstract Traditional competitive markets do not account for negative externalities; indirect costs that some participants impose on others, such as the cost of over-appropriating a common-pool resource (which diminishes future stock, and thus harvest, for everyone). Quantifying a...

Faculty Uses and Perspectives on Generative AI: Experiences From Two UK Veterinary Schools

Abstract The relatively recent emergence of generative AI (GenAI) tools and their potential to influence many aspects of faculty and student experiences requires rapid insight into these tools’ current uses, perceived challenges, and opportunities. A survey-based study was carrie...

Crystals in rhyolitic melts can nucleate multiple bubbles: an experimentally constrained model

Abstract Heterogeneous nucleation of bubbles on crystals in magma is thought to be an important driver of volcanic eruptions. Decompression experiments were carried out to elucidate the kinetics of H 2 O bubble nucleation on crystals of different sizes. Samples used were mixtures...

Information Infrastructure and Institutional Strategy: Academic Libraries in the Higher Education Policy Landscape

AbstractAcademic libraries increasingly serve as strategic components of higher education governance, extending beyond their traditional role as information repositories to support institutional sustainability, digital transformation, policy implementation, and knowledge producti...

Melting experiments and the origins of felsic crust on early Earth

Understanding the origin of Earth's earliest felsic crust has been a fundamental question in geology since the foundational insights of James Hutton and the pioneering high-temperature melting experiments of James Hall. Building on this historical framework, this study synthesise...

In Silico Phosphoproteomic Profiling of the MAP3K3 Signaling Network

Background: Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) is a serine/threonine kinase that exhibits oncogenic activity in various cancers. Despite the established role of MAP3K3 in signal transduction, its phosphosignaling landscape, including the mechanisms underlyi...

Adaptive underwater 3D surface scanning using Bayesian optimisation: A controlled proof-of-concept for suction-caisson applications

Suction caisson installation can be affected by soil plug hazards such as plug heave, uplift, and uneven plug geometry. Current internal monitoring methods generally provide measurements at a single location and may not resolve the full surface expression of asymmetric uplift. Th...

Hierarchical microbial distribution organized by ordered river structure explains why GHG emission favors small streams

In river networks, small streams usually emit the largest proportion of greenhouse-gases (GHGs). However, the associated microbial mechanisms affected by the hierarchy of river systems are unclear. To address this, we measured N 2 O, CH 4 and CO 2 fluxes at 22 sites selected from...

A qualitative evaluation of a community‐based approach to protected area law enforcement

Abstract People living in and around terrestrial and marine protected areas can contribute to protected area law enforcement in different ways. While the involvement of local residents is considered important for bringing benefits to both conservation and people, evaluations of c...

Early insights into predicted efficacy of Ebola monoclonal antibodies for the 2026 Bundibugyo virus disease outbreak

The 2026 Bundibugyo virus disease (BVD) outbreak in the DRC and Uganda raises urgent questions about the efficacy of existing Ebola virus (EBOV) monoclonal antibodies (mAbs) against Bundibugyo virus (BDBV). Here, we perform genomic and structural analyses of 44 BDBV sequences, in...

Adaptive multilevel stochastic approximation of the value-at-risk

Crépey, Frikha and Louzi (Finance Stoch. (2025) 1015–1074) introduced a multilevel stochastic approximation scheme to compute the value-at-risk of a financial loss that is only simulatable by Monte Carlo. The best complexity of the scheme is in O(ε−52), ε>0 being a prescribed acc...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Unequal Dynamics of Ecological Regeneration and Anthropogenic Persistence During Landscape Transition in Krzemionki, Kraków

Post-socialist urban landscapes often undergo spontaneous transformation where formal governance is fragmented or discontinuous, yet the spatial logic of these transitions remains insufficiently quantified. This study examines Krzemionki, a landscape archaeological heritage site...

Becoming revenants: An exploration of magical contagion, shame and stigma after imprisonment

This paper explores the process of becoming revenant, returning from the social death of imprisonment. It is an autoethnographic inquiry into how we women cope with the spectres of shame and stigma of imprisonment when we are contaminated by the emotional residues of prison. In i...