University of Cambridge

Induction of the filamentous prophage, Pf4, is conditionally regulated by PA3572 (difP) in Pseudomonas aeruginosa biofilms

Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen, often associated with airway infections in the lungs of people with cystic fibrosis (CF). Biofilms of many P. aeruginosa strains, such as PAO1, produce copious quantities of filamentous Pf4 phage. High titres of P...

Randomised phase III trials of cancer prevention drugs: a systematic review and prediction of trial success

BACKGROUND: Pharmacological cancer risk reduction has received far less investment than therapeutic oncology and only a few agents have entered routine practice. Understanding the predictors of positive outcomes of previous trials and issues faced is critical to future developmen...

Decoupling Triplet Population from Intersystem Crossing in TADF Materials

Abstract The characterization of thermally activated delayed fluorescence (TADF) relies on detecting delayed emission following triplet formation. However, triplet population under optical excitation is fundamentally limited by the intrinsic intersystem crossing (ISC) efficiency...

Psychological safety, anxiety and professional identity among UK surgical physician associates

Abstract Background Physician Associates (PAs) are increasingly embedded within UK surgical teams, yet little is known about their psychological safety, occupational wellbeing, risk orientation, exposure to online hostility, or career aspirations. Surgical PAs represent a small s...

Dust Substructures and Line Perturbations driven by a Forming Planet in J16120

Abstract Hints of planet formation have been independently reported within the gap of the disc around 2MASS J16120668-301027 from millimetre continuum, infrared, and Hα observations. In this work, we present new evidence for ongoing planet formation based on Atacama Large Millime...

Immune dysregulation in depression and psychosis: summary of current evidence and future perspectives

Despite compelling epidemiological, genetic and cellular evidence linking immune dysregulation to depression and schizophrenia (and other psychotic disorders), causality remains contested and no immune biomarker has yet demonstrated robust clinical utility. Emerging methodologica...

Experiments on entrainment and mixing in particle-driven gravity currents

New experiments with particle-driven, finite-volume gravity currents show that some of the ambient fluid displaced up and over the head of the current becomes mixed into the current. Measurements show that this leads to an increase in volume of the current at a similar rate to th...

The changing political meaning of nuclear weapons in North Korea

This article examines how political meanings of nuclear weapons in North Korean official language changed and accumulated from the first nuclear crisis of the early 1990s to Pyongyang’s declaration of the completion of its state nuclear force in 2017. Rather than asking why North...

Impact of LIFE training on educational staff’s suicide prevention skills and confidence levels

Purpose This study aims to assess the impact of LIFE training on educational staff’s confidence in communication skills that can support students in suicidal distress. Design/methodology/approach LIFE training is a school-based suicide prevention course designed to develop educat...

Hip and groin pain in physically active adults with a focus on terminology, clinical examination and imaging: A formal ESSKA‐EHPA‐ESMA Consensus

Abstract Purpose This European Society of Sports Traumatology, Knee Surgery and Arthroscopy–European Hip Preservation Associates–European Sports Medicine Association (ESSKA‐EHPA‐ESMA) formal consensus aims to provide evidence‐ and expert opinion‐based recommendations for the term...

Evolution of the Cytochrome P450 Family 4 (CYP4) Subfamilies in Birds

Data for manuscript: Evolution of the Cytochrome P450 Family 4 (CYP4) Subfamilies in Birds (https://www.biorxiv.org/content/10.64898/2026.02.03.700598v1) For details, please see the latest version of the manuscript. This version uploaded on 2026-September-7th contains stochastic...

Expanding Oued Beht: Final Neolithic, Bronze Age, medieval and later discoveries from excavation and survey in 2023

Abstract Oued Beht, Morocco, is emerging as a key site for understanding later prehistory in the northwestern Maghreb. Previous fieldwork by the Oued Beht Archaeological Project (OBAP) in 2022 revealed major evidence of a large and complex focus of activity across the ridge durin...

The Sovereign and the Machine: Hamlet’s Corporate Death

This article rereads Akira Kurosawa’s 1960 film The Bad Sleep Well as a modern Hamlet that relocates Shakespeare’s crisis of action from dynastic succession to postwar bureaucratic and corporate modernity. It shifts attention away from plot fidelity and toward how Hamletian funct...

From facing fears to experimental frontiers: immersive cinematic virtual reality environments as a catalyst for innovation in behavioral neuroscience

Virtual reality (VR) has gained traction in psychiatric research in exposure-based interventions for phobias, simulations of hallucinations in psychosis, and adaptations of cognitive-behavioral therapy. These applications demonstrate that emotionally immersive digital environment...

Magnetic insights into the aqueous alteration of CM chondrites

CM chondrites are the archetypal group of aqueously altered meteorites, preserving records of water-rock interactions on planetesimals. Here, we couple rock magnetic properties with modal mineralogy measured from 48 CM chondrites to explore aqueous alteration through its influenc...

Stakeholder Perspectives on Whether and How Social Robots Can Support Self-Advocacy for Higher Education Students with Disabilities

This paper presents an iterative, participatory, empirical study that examines the potential of using artificial intelligence, such as social robots and large language models, to support mediation and advocacy for disabled students in higher education. Drawing on qualitative data...

Neural signatures of altered adaptation to repetitive auditory stimulation in tinnitus

Abstract A growing body of studies has explored tinnitus within a predictive coding framework, proposing that predictive mechanisms may contribute to its development and persistence. However, many aspects of this relationship remain to be clarified. While mismatch negativity (MMN...

Modelling the photocatalytic oxidation of methane and other air pollutants for applications in ventilation systems

Photocatalytic oxidation (PCO) is a promising strategy for indoor air purification and outdoor pollutant abatement, potentially offering treatment for climate- and health-relevant pollutants such as methane (CH$_4$), nitrogen oxides (NO$_\text{x}$) and volatile organic compounds...

Morpho-functional innovations in Shibantan fossils fuel Ediacaran frond debates

The Ediacara biota represents Earth’s earliest complex macroscopic organisms, but their biology and ecology remain poorly understood. Here we report Dengyingia pennata gen. et sp. nov., an exceptionally preserved frondose fossil from the late Ediacaran ( ~550–543 Ma) Shibantan li...

Depressive Symptoms Trajectories Across the Transition to Cardiovascular Disease in Middle-Aged and Older Adults: A Multicohort Study

Abstract Aims The long-term depressive symptoms trajectories across the transition to diagnosed cardiovascular disease (CVD) remain poorly characterized. We aimed to investigate trajectories of depressive symptoms before and after incident CVD in multinational aging populations....