University of California San Diego

Sea surface warming suppresses primary sea spray aerosol number production

Abstract. Sea spray aerosol (SSA) influences climate through direct and indirect interactions with radiation. However, the magnitudes of these interactions remain poorly constrained, in part due to a lack of understanding of the influences of sea surface temperature (SST) on SSA...

Using Tower‐Based Observational Networks to Assess the Impact of COVID‐19 Lockdowns on Greenhouse Gas Emissions in Six North American Cities

Abstract The onset of the COVID‐19 pandemic in North America and the lockdowns that followed in March 2020 brought forth a rapid change to societal functions disrupting many aspects of normal life, including the greenhouse gas emissions associated with them. In this work, we exam...

The importance of classifying central hypopneas: a call to action

Obstructive and central sleep apnea share pathophysiologic features and often coexist within individual patients. There is general agreement on the criteria for scoring obstructive and central apneas but less guidance and clarity on how and when to classify obstructive and centra...

Associations Between Combat Exposure, Traumatic Brain Injury, and Sleep Outcomes Among Post-9/11 Veterans

OBJECTIVE: The authors examined the relationship between veterans' combat experiences and multiple dimensions of sleep health and how traumatic brain injury (TBI) history may modulate these relationships. METHODS: Participants were 17,812 post-9/11 veterans (mean±SD age=46.6±10.8...

All-optical multimodal mapping of single-cell-type-specific metabolic activities via REDCAT

Abstract Metabolism is fundamental to cell function, yet its activities vary across tissue environments. Resolving these processes in situ at single-cell resolution is crucial for understanding physiology in health and disease. However, existing methods lack biochemical specifici...

Targeted ATAC-see (tATAC-see): A visual assay for target-specific chromatin profiling

We present targeted ATAC-see (tATAC-see), a visual genomics assay for site-specific chromatin profiling. By integrating the in situ visualization of ATAC-see with antibody-tethered tagmentation, tATAC-see captures chromatin states at defined protein-occupied domains with the simp...

Feasibility of Real‐Time Central Risk Assignment for Children's Oncology Group Pediatric Renal Tumor Trials

BACKGROUND: The Children's Oncology Group (COG) AREN03B2 Renal Tumor Biology and Classification Study undertook real-time central reviews to enable accurate risk stratification for enrollment on therapeutic trials. The present study assessed the feasibility of the central review...

De novo design of RNA pseudoknots with deep learning

RNA design has been hindered by the limited accuracy of 3D structure prediction. Here, we show that intricate RNA structures can be generated with current deep learning tools through accurate de novo design of pseudoknot secondary structures. In an Eterna competition involving 57...

Cognitive Behavior vs Bright Light Therapy for Insomnia in Women Undergoing Chemotherapy for Breast Cancer

Importance Women receiving chemotherapy for breast cancer experience insomnia and fatigue, which impair quality of life. To date, no randomized clinical trial (RCT) has evaluated the use of cognitive behavior therapy for insomnia (CBT-I) and bright light therapy (BLT) both alone...

Feasibility of implementing collaborative decision skills training among veterans with psychosis: a qualitative study guided by the practical, robust implementation and sustainability model

Abstract Background Collaborative Decision Skills Training (CDST) is a promising group intervention for adults with serious mental illness (SMI) intended to increase collaborative decision-making (CDM) at the patient-clinician level. CDST previously underwent a systematic, commun...

Maxillary Distraction Osteogenesis as both Bridge to and Replacement for Orthognathic Surgery in Patients with Cleft Lip and Palate

Background: Although maxillary distraction osteogenesis (MaxDO) has demonstrated superior bone healing in patients with cleft lip and palate (CLP), its clinical use is relatively unreported. Questions persist regarding its effectiveness in treating severe maxillary retrusion, its...

Trends in Pathogens Causing Late-Onset Sepsis in Very Preterm Infants: 2010–2023

OBJECTIVE To examine long-term trends in overall and pathogen-specific late-onset sepsis (LOS) incidence among very preterm infants (VPIs) in a statewide, population-based network. METHODS We analyzed data for infants born at 22 to 31 weeks’ gestation in the California Perinatal...

Cannabis and Wound Healing: A Narrative Review of Current Evidence and Applications to Facial Plastic Surgery

Cannabis use has increased substantially in the United States, driven by broader legalization, decriminalization, and expanding medical and recreational availability. For facial plastic surgeons, the clinical implications remain difficult to define because “cannabis use” encompas...

PDA Stenting with Versus Without Pre-Procedural 3D Reconstruction: Impact on Radiation Exposure and Procedural Outcomes

Abstract Background Managing patients with patent ductus arteriosus (PDA) and complex anatomical features, such as tortuosity and branching anomalies, remains a challenge in interventional cardiology. Recent advances in three-dimensional (3D) reconstruction and quantitative analy...

Goals, Expectations, and Performance

People and organizations often set goals to self-motivate and achieve better outcomes in challenging tasks. But goals, and their effectiveness, might depend on what people expect to happen. Do goals reflect expectations or do goals set expectations? How do goals and expectations...

Mechanochemical modeling of exercise-induced skeletal muscle hypertrophy

ABSTRACT Skeletal muscle displays remarkable plasticity, adapting its size and strength in response to mechanical loading, particularly, from exercise. This process, known as hypertrophy, is fundamental to athletic training and rehabilitation, but is challenging to quantitatively...

USP10 mitigates Ang II–induced atrial remodeling and atrial fibrillation susceptibility by deubiquitinating NDUFS1

Atrial fibrillation (AF) contributes to cardiovascular morbidity and mortality. Ubiquitin-specific peptidase 10 (USP10) plays a crucial role in numerous cellular processes; however, its particular role in AF remains largely unexplored. In the present study, USP10 expression was a...

Leveraging the private sector for health system development in sub-Saharan Africa

Development assistance has historically supported major gains in health and health-system development in sub-Saharan Africa, but recent reductions in development assistance have intensified financing and service-delivery pressures across the region. As governments seek more durab...

Responsiveness of epigenetic aging biomarkers to longevity interventions in humans

Abstract Aging biomarkers can potentially allow researchers to rapidly monitor the impact of an aging intervention without the need for decade-spanning trials. However, before the use of aging biomarkers, such as epigenetic clocks, as surrogate endpoints, their responsiveness to...

Microsolvation of Protonated Glycine: Infrared Spectra from Data-Driven Quantum Many-Body Simulations

Abstract Understanding how hydration reshapes the structure and conformational flexibility of biomolecular ions is essential for connecting gas-phase spectroscopy to behavior in aqueous environments. Glycine, the simplest amino acid, exhibits rich microsolvation behavior, with co...