University of California San Diego

Changes in adult cannabis use patterns following retail availability in California (2017 to 2024)

Abstract Background California was among the earliest U.S. states to legalize non-medical cannabis use by adults, with retail availability beginning January 1, 2018. This study describes changes in cannabis use prevalence, frequency, and methods among adults in California from 20...

Real-world use of large language models for mental health in 2024

The extent to which people use general-purpose large language models (LLMs) for their mental health is unknown. Information about use patterns is important for clinicians, developers, and regulators. We surveyed U.S. adults ( n = 1871) between August and October 2024 using strati...

Machine learning analysis of the human initiator region reveals key features of different types of core promoters

The initiator (Inr) is the starting point for the transcription of many genes. Here, we generated highly predictive machine learning models of the human Inr region, and determined that the Inr is present in ∼60% of focused human promoters, identified a novel TATA-specific Inr, an...

Peritoneal Dialysis Outcomes in Autosomal Dominant Polycystic Kidney Disease

Background: Peritoneal dialysis (PD) is a form of home dialysis that is underutilized in the United States. Patients with autosomal dominant polycystic kidney disease (ADPKD) are frequently good PD candidates who are often young and have few comorbid conditions. However, clinicia...