University of California San Diego

Effect of Aficamten on Cardiac Structure and Function in Patients with Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Aficamten significantly improved both functional capacity and patient-reported health status in patients with symptomatic nonobstructive hypertrophic cardiomyopathy in the phase 3 randomized, placebo-controlled ACACIA-HCM trial (Assessment Comparing Aficamten to Place...

Précis to Revisionism in Four Views on Free Will, 2e

Abstract This article provides an overview of Manuel Vargas’ newly reformulated approach to revisionary compatibilism about free will, as presented in the second edition of Four Views on Free Will (2024).

Abridged Retinal Fluorescence Lifetimes in Glaucoma

This study investigates the relationship between glaucoma and retinal fluorescence lifetimes using FLIO. The results show that participants with glaucoma have shorter mean lifetimes compared to those without glaucoma, even after adjusting for age and diabetes status. The study su...

Permutationally symmetric molecular aggregates

Linear optical spectra of molecular aggregates are often approximated by classical optics methods such as the discrete-dipole approximation (DDA), coherent exciton scattering (CES), and coherent potential approximation (CPA), where the only quantum-mechanical input to the calcula...

Learning precise segmentation of neurofibrillary tangles from rapid manual point annotations

Accumulation of abnormal tau protein into neurofibrillary tangles (NFTs) is a pathologic hallmark of Alzheimer disease (AD). Accurate detection of NFTs in tissue samples can reveal relationships with clinical, demographic, and genetic features through deep phenotyping. However, e...

Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (HCM) is a common condition that is associated with substantial morbidity and no proven medical therapy. Whether treatment with aficamten, a cardiac myosin inhibitor, can benefit patients with this condition is unknown. METHO...

Using Tower‐Based Observational Networks to Assess the Impact of COVID‐19 Lockdowns on Greenhouse Gas Emissions in Six North American Cities

Abstract The onset of the COVID‐19 pandemic in North America and the lockdowns that followed in March 2020 brought forth a rapid change to societal functions disrupting many aspects of normal life, including the greenhouse gas emissions associated with them. In this work, we exam...

Sea surface warming suppresses primary sea spray aerosol number production

Abstract. Sea spray aerosol (SSA) influences climate through direct and indirect interactions with radiation. However, the magnitudes of these interactions remain poorly constrained, in part due to a lack of understanding of the influences of sea surface temperature (SST) on SSA...

Global Efficacy of Aficamten in Nonobstructive Hypertrophic Cardiomyopathy: Results From ACACIA-HCM

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (nHCM) is associated with significant morbidity with no approved treatment. Aficamten is a cardiac myosin inhibitor targeting excess contractility and diastolic impairment, the predominant mechanism responsible for adverse ou...

Observation of Yanai Wave Excitation by Tropical Instability Waves in the Equatorial Pacific

Abstract Yanai waves are observed in the central equatorial Pacific at 436–864 m depth, below the Equatorial Undercurrent. Applying maximum likelihood estimation to shipboard ADCP measurements enables identification of Yanai wave signals from irregularly sampled observations. Ray...

Targeted ATAC-see (tATAC-see): A visual assay for target-specific chromatin profiling

We present targeted ATAC-see (tATAC-see), a visual genomics assay for site-specific chromatin profiling. By integrating the in situ visualization of ATAC-see with antibody-tethered tagmentation, tATAC-see captures chromatin states at defined protein-occupied domains with the simp...

Feasibility of Real‐Time Central Risk Assignment for Children's Oncology Group Pediatric Renal Tumor Trials

BACKGROUND: The Children's Oncology Group (COG) AREN03B2 Renal Tumor Biology and Classification Study undertook real-time central reviews to enable accurate risk stratification for enrollment on therapeutic trials. The present study assessed the feasibility of the central review...

The importance of classifying central hypopneas: a call to action

Obstructive and central sleep apnea share pathophysiologic features and often coexist within individual patients. There is general agreement on the criteria for scoring obstructive and central apneas but less guidance and clarity on how and when to classify obstructive and centra...

De novo design of RNA pseudoknots with deep learning

RNA design has been hindered by the limited accuracy of 3D structure prediction. Here, we show that intricate RNA structures can be generated with current deep learning tools through accurate de novo design of pseudoknot secondary structures. In an Eterna competition involving 57...

Cognitive Behavior vs Bright Light Therapy for Insomnia in Women Undergoing Chemotherapy for Breast Cancer

Importance Women receiving chemotherapy for breast cancer experience insomnia and fatigue, which impair quality of life. To date, no randomized clinical trial (RCT) has evaluated the use of cognitive behavior therapy for insomnia (CBT-I) and bright light therapy (BLT) both alone...

Associations Between Combat Exposure, Traumatic Brain Injury, and Sleep Outcomes Among Post-9/11 Veterans

OBJECTIVE: The authors examined the relationship between veterans' combat experiences and multiple dimensions of sleep health and how traumatic brain injury (TBI) history may modulate these relationships. METHODS: Participants were 17,812 post-9/11 veterans (mean±SD age=46.6±10.8...

All-optical multimodal mapping of single-cell-type-specific metabolic activities via REDCAT

Abstract Metabolism is fundamental to cell function, yet its activities vary across tissue environments. Resolving these processes in situ at single-cell resolution is crucial for understanding physiology in health and disease. However, existing methods lack biochemical specifici...

Maxillary Distraction Osteogenesis as both Bridge to and Replacement for Orthognathic Surgery in Patients with Cleft Lip and Palate

Background: Although maxillary distraction osteogenesis (MaxDO) has demonstrated superior bone healing in patients with cleft lip and palate (CLP), its clinical use is relatively unreported. Questions persist regarding its effectiveness in treating severe maxillary retrusion, its...

Feasibility of implementing collaborative decision skills training among veterans with psychosis: a qualitative study guided by the practical, robust implementation and sustainability model

Abstract Background Collaborative Decision Skills Training (CDST) is a promising group intervention for adults with serious mental illness (SMI) intended to increase collaborative decision-making (CDM) at the patient-clinician level. CDST previously underwent a systematic, commun...

Trends in Pathogens Causing Late-Onset Sepsis in Very Preterm Infants: 2010–2023

OBJECTIVE To examine long-term trends in overall and pathogen-specific late-onset sepsis (LOS) incidence among very preterm infants (VPIs) in a statewide, population-based network. METHODS We analyzed data for infants born at 22 to 31 weeks’ gestation in the California Perinatal...