University of California, Irvine

Association of lipoprotein(a) with cardiovascular outcomes and breast arterial calcification in postmenopausal women

This study examined the association of lipoprotein(a) [Lp(a)] with breast arterial calcification (BAC) and incident cardiovascular disease (CVD) in postmenopausal women. We analyzed data from 2,799 women in the MINERVA cohort (ages 60–79 years; 34% non-white) free of CVD at basel...

Local Pharmacokinetics and Tolerability of Topically‐Applied Bimatoprost to the Scalp of Male Patients With Androgenetic Alopecia

ABSTRACT Androgenetic alopecia (AGA) is one of the most common causes of hair loss in the male population, characterized by progressive baldness. This study was designed to evaluate the tolerability and local skin pharmacokinetics of bimatoprost in two different formulations in m...

Brush-mediated angular constraints reshape structure, rigidity, and percolation in colloidal depletion gels

Colloidal gels, like many other soft and disordered solids derive their mechanical properties not only from the strength of interparticle attraction but also from the symmetry of the forces that constrain particle motion. Although noncentral interactions are known to profoundly a...

Frequency effects of alternating dielectric-barrier-discharge plasma actuation on turbulent flow of circular cylinder

Abstract An in-house solver for the three-dimensional, unsteady, compressible Navier–Stokes equations with a large-eddy simulation (LES) turbulence model is applied to simulate the unsteady flow over a circular cylinder at a Reynolds number of 15,000 under the control of a pair o...

Enriched experience increases reciprocal synaptic connectivity and coding sparsity in higher-order cortex

The integration of new information during sleep reshapes cortical representations that support categorical knowledge. Auto-associative attractor network theories predict that reciprocal excitatory connections help form stable categorical attractors, but direct evidence is missing...

Piecewise Constraintsfor Exact End Point Samplingwith λ-Dynamics

Abstract λ-Dynamics simulations are used to explore differences between distinct chemical states through interpolation with a λ parameter. Existing algorithms for λ-dynamics treat the thermodynamic coupling parameter λ as an additional degree of freedom and integrate its motion a...

Chitin‐Derived Carbon‐Metal Functional Materials

ABSTRACT Biomass‐derived carbon materials have emerged as sustainable alternatives to petroleum‐derived adsorbents for environmental remediation applications. Among biomass feedstocks, chitin offers advantages due to its abundance as seafood‐processing waste and its intrinsic nit...

The Ultimate Legal Fiction: Knowing and Intelligent Guilty Pleas

Abstract Guilty pleas dominate the resolution of criminal charges in the U.S. criminal justice system. In entering guilty pleas, the law is clear that defendants must do so knowingly and intelligently (and voluntarily) for the plea to be deemed valid. The belief that defendants w...

Hemodynamic Effects of Topical Oxymetazoline During Pediatric Flexible Bronchoscopy

BACKGROUND: Bleeding is a well-recognized complication in flexible bronchoscopy, especially with advanced procedures. Oxymetazoline is a topical vasoconstrictor often used to reduce or treat bleeding in the nares and airways. METHODS: A retrospective cohort study was conducted on...

Heterogeneous Individual Valuations of a Mild Climate

Abstract This paper explores heterogeneous individual valuations of an important amenity, climate mildness, using a traditional Rosen-Roback empirical framework. It does so by including interaction terms between the amenity and worker characteristics in an hedonic wage regression...

Microbial inoculants for soil restoration: A Risk-Proportional Stewardship Framework Integrating Strain-Resolved Genomics and Adaptive Governance

Abstract Global soil degradation and increasing reliance on chemical inputs threaten agricultural sustainability, driving interest in microbial inoculants as tools for soil restoration. These biological products have the potential to enhance nutrient cycling, improve soil structu...

Detection of False Stealthy Data Injection Attacks in Smart Meters Using Machine Learning and Blockchain Technology

Despite the benefits associated with the use of smart meters in advanced metering infrastructure, the widespread deployment of such meters has introduced vulnerabilities that leave power systems susceptible to stealthy false data injection attacks which cannot be detected by conv...

Anxiety and mood disorders from childhood to adulthood in very preterm and term-born individuals

BACKGROUND: Very preterm (VP) birth has been associated with higher rates of anxiety and mood disorders, but the emergence and persistence from childhood to adulthood is unknown. This study examined prevalence rates and early risk factors of these disorders in VP and term-born in...

Data-Driven Modal Decomposition Analysis of Unsteady Flow in Multistage Turbine

Two data-driven modal analysis approaches, proper orthogonal decomposition (POD) and dynamic mode decomposition (DMD), are applied to analyze the unsteady flow obtained by solving the Reynolds-averaged Navier–Stokes (RANS) equations in a 1.5-stage axial turbine. The reduced-order...

On the Lawson-Osserman conjecture

Abstract We prove that if $u : B_{1} \subset \mathbb{R}^{2} \rightarrow \mathbb{R}^{n}$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>u</mml:mi> <mml:mo>:</mml:mo> <mml:msub> <mml:mi>B</mml:mi> <mml:mn>1</mml:mn> </mml:msub> <mml:mo>⊂</mml:mo> <mml:msup> <mml:...

Reconstitution of lamin assembly on nuclear pore complex-containing membranes

Intermediate filaments called lamins line the metazoan nuclear envelope and organize the nucleus and genome. Unlike actin and microtubules, purified intermediate filament proteins assemble into non-physiological structures, making it difficult to connect lamin functions to their...

Rethinking fossil fuel divestment: Land, labor, and crises of overaccumulation

Research on fossil fuel divestment has thus far focused on the efficacy of shifting finance away from fossil fuels to decarbonize investment portfolios. Drawing on a comparative analysis of fossil fuel divestment movements across the Asia Pacific, this article instead situates di...

Total Ozone Reactivity Measurements Reveal Knowledge Gap in Volatile Organic Compound Emissions and Their Reactions

Abstract Total ozone (O 3 ) reactivity monitors (TORMs) were used to investigate biogenic volatile organic compound (BVOC) emissions from several ecosystems. Measurements were conducted in temperate deciduous North American forests, during the CABINEX and SOAS campaigns, on tundr...

UCI BioEYEs: A Graduate-Student-Led Model for Sustainable, Inclusive Science Outreach

Zebrafish are a powerful, accessible vertebrate model for teaching core biology concepts. BioEYES is a well-established K-12 outreach program that uses inquiry-based classroom investigations to leverage these strengths. However, its traditional model relies on dedicated personnel...

La Niña’s longevity shapes Bering Sea ice fate

Abstract La Niña events vary widely in duration, from single-year to multi-year. However, their influence on Bering Sea ice concentration remains unclear. Here, we show that single-year and multi-year La Niña events produce contrasting impacts on spring Bering Sea ice concentrati...